Three-Component Synthesis of Polysubstituted Homoproline Analogs

Tetrasubstituted pyrrolidines representing analogs of homoproline weresynthesized by three-component condensation of aryl(heteroaryl)aldehydes, asparagineand N-methylmaleimide (NMM). Compounds with (1S*, 3R*, 3aS*, 6aR*)-configurationat the corresponding carbon positions of the bicyclic pyrrolidine...

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Main Authors: V. Irkha, K. Kudryavtsev
Format: Article
Language:English
Published: MDPI AG 2005-08-01
Series:Molecules
Subjects:
Online Access:http://www.mdpi.com/1420-3049/10/7/755/
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author V. Irkha
K. Kudryavtsev
author_facet V. Irkha
K. Kudryavtsev
author_sort V. Irkha
collection DOAJ
description Tetrasubstituted pyrrolidines representing analogs of homoproline weresynthesized by three-component condensation of aryl(heteroaryl)aldehydes, asparagineand N-methylmaleimide (NMM). Compounds with (1S*, 3R*, 3aS*, 6aR*)-configurationat the corresponding carbon positions of the bicyclic pyrrolidine ring could be isolated ona preparative scale.
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spelling doaj.art-61453cdad2554afdae1cb8933df1d6b42022-12-21T18:33:36ZengMDPI AGMolecules1420-30492005-08-0110775576110.3390/10070755Three-Component Synthesis of Polysubstituted Homoproline AnalogsV. IrkhaK. KudryavtsevTetrasubstituted pyrrolidines representing analogs of homoproline weresynthesized by three-component condensation of aryl(heteroaryl)aldehydes, asparagineand N-methylmaleimide (NMM). Compounds with (1S*, 3R*, 3aS*, 6aR*)-configurationat the corresponding carbon positions of the bicyclic pyrrolidine ring could be isolated ona preparative scale.http://www.mdpi.com/1420-3049/10/7/755/Multicomponent reactions13-dipolar cycloadditionhomoproline.
spellingShingle V. Irkha
K. Kudryavtsev
Three-Component Synthesis of Polysubstituted Homoproline Analogs
Molecules
Multicomponent reactions
1
3-dipolar cycloaddition
homoproline.
title Three-Component Synthesis of Polysubstituted Homoproline Analogs
title_full Three-Component Synthesis of Polysubstituted Homoproline Analogs
title_fullStr Three-Component Synthesis of Polysubstituted Homoproline Analogs
title_full_unstemmed Three-Component Synthesis of Polysubstituted Homoproline Analogs
title_short Three-Component Synthesis of Polysubstituted Homoproline Analogs
title_sort three component synthesis of polysubstituted homoproline analogs
topic Multicomponent reactions
1
3-dipolar cycloaddition
homoproline.
url http://www.mdpi.com/1420-3049/10/7/755/
work_keys_str_mv AT virkha threecomponentsynthesisofpolysubstitutedhomoprolineanalogs
AT kkudryavtsev threecomponentsynthesisofpolysubstitutedhomoprolineanalogs