Neutrophil-lymphocyte ratio change after curative gastrectomy for gastric cancer: a subgroup analysis
ABSTRACT Objective: To evaluate the impact of neutrophil-lymphocyte ratio change after curative surgery for gastric cancer. Methods: A retrospective analysis of patients with gastric cancer who underwent curative surgery between 2009 and 2017 was performed. A cutoff value was established for the n...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Instituto Israelita de Ensino e Pesquisa Albert Einstein
2019-11-01
|
| Series: | Einstein (São Paulo) |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082020000100215&tlng=en |
| _version_ | 1818745130266394624 |
|---|---|
| author | Daniel José Szor André Roncon Dias Marina Alessandra Pereira Marcus Fernando Kodama Pertille Ramos Bruno Zilberstein Ivan Cecconello Ulysses Ribeiro Júnior |
| author_facet | Daniel José Szor André Roncon Dias Marina Alessandra Pereira Marcus Fernando Kodama Pertille Ramos Bruno Zilberstein Ivan Cecconello Ulysses Ribeiro Júnior |
| author_sort | Daniel José Szor |
| collection | DOAJ |
| description | ABSTRACT Objective: To evaluate the impact of neutrophil-lymphocyte ratio change after curative surgery for gastric cancer. Methods: A retrospective analysis of patients with gastric cancer who underwent curative surgery between 2009 and 2017 was performed. A cutoff value was established for the neutrophil-lymphocyte ratio in the pre- and postoperative periods, according to the median value, and four subgroups were formed (low-low/low-high/high-low/high-high). Clinical-pathological and survival data were analyzed and related to these subgroups. Results: A total of 325 patients were included in the study. The cutoff values of the neutrophil-lymphocyte ratio were 2.14 and 1.8 for the pre and postoperative periods, respectively. In patients with stages I and II, the high-high subgroup presented worse overall survival (p=0.016) and disease-free survival (p=0.001). Complications were higher in the low-high subgroup of patients. Conclusion: The neutrophil-lymphocyte ratio is a low cost, efficient and reproducible marker. The prognosis individualization can be performed according to the identification of subgroups at a higher risk of complications and worse prognosis. |
| first_indexed | 2024-12-18T02:55:18Z |
| format | Article |
| id | doaj.art-6146f7e6d8e14e8e8c33883ebee39647 |
| institution | Directory Open Access Journal |
| issn | 2317-6385 |
| language | English |
| last_indexed | 2024-12-18T02:55:18Z |
| publishDate | 2019-11-01 |
| publisher | Instituto Israelita de Ensino e Pesquisa Albert Einstein |
| record_format | Article |
| series | Einstein (São Paulo) |
| spelling | doaj.art-6146f7e6d8e14e8e8c33883ebee396472022-12-21T21:23:23ZengInstituto Israelita de Ensino e Pesquisa Albert EinsteinEinstein (São Paulo)2317-63852019-11-011810.31744/einstein_journal/2020ao4860Neutrophil-lymphocyte ratio change after curative gastrectomy for gastric cancer: a subgroup analysisDaniel José Szorhttps://orcid.org/0000-0002-9727-9241André Roncon Diashttps://orcid.org/0000-0003-3378-4916Marina Alessandra Pereirahttps://orcid.org/0000-0002-6865-0988Marcus Fernando Kodama Pertille Ramoshttps://orcid.org/0000-0003-0200-7858Bruno Zilbersteinhttps://orcid.org/0000-0002-1809-8558Ivan Cecconellohttps://orcid.org/0000-0002-3535-4170Ulysses Ribeiro Júniorhttps://orcid.org/0000-0003-1711-7347ABSTRACT Objective: To evaluate the impact of neutrophil-lymphocyte ratio change after curative surgery for gastric cancer. Methods: A retrospective analysis of patients with gastric cancer who underwent curative surgery between 2009 and 2017 was performed. A cutoff value was established for the neutrophil-lymphocyte ratio in the pre- and postoperative periods, according to the median value, and four subgroups were formed (low-low/low-high/high-low/high-high). Clinical-pathological and survival data were analyzed and related to these subgroups. Results: A total of 325 patients were included in the study. The cutoff values of the neutrophil-lymphocyte ratio were 2.14 and 1.8 for the pre and postoperative periods, respectively. In patients with stages I and II, the high-high subgroup presented worse overall survival (p=0.016) and disease-free survival (p=0.001). Complications were higher in the low-high subgroup of patients. Conclusion: The neutrophil-lymphocyte ratio is a low cost, efficient and reproducible marker. The prognosis individualization can be performed according to the identification of subgroups at a higher risk of complications and worse prognosis.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082020000100215&tlng=enStomach neoplasmsPrognosisBiomarkersInflammationGastrectomy |
| spellingShingle | Daniel José Szor André Roncon Dias Marina Alessandra Pereira Marcus Fernando Kodama Pertille Ramos Bruno Zilberstein Ivan Cecconello Ulysses Ribeiro Júnior Neutrophil-lymphocyte ratio change after curative gastrectomy for gastric cancer: a subgroup analysis Einstein (São Paulo) Stomach neoplasms Prognosis Biomarkers Inflammation Gastrectomy |
| title | Neutrophil-lymphocyte ratio change after curative gastrectomy for gastric cancer: a subgroup analysis |
| title_full | Neutrophil-lymphocyte ratio change after curative gastrectomy for gastric cancer: a subgroup analysis |
| title_fullStr | Neutrophil-lymphocyte ratio change after curative gastrectomy for gastric cancer: a subgroup analysis |
| title_full_unstemmed | Neutrophil-lymphocyte ratio change after curative gastrectomy for gastric cancer: a subgroup analysis |
| title_short | Neutrophil-lymphocyte ratio change after curative gastrectomy for gastric cancer: a subgroup analysis |
| title_sort | neutrophil lymphocyte ratio change after curative gastrectomy for gastric cancer a subgroup analysis |
| topic | Stomach neoplasms Prognosis Biomarkers Inflammation Gastrectomy |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082020000100215&tlng=en |
| work_keys_str_mv | AT danieljoseszor neutrophillymphocyteratiochangeaftercurativegastrectomyforgastriccancerasubgroupanalysis AT andreroncondias neutrophillymphocyteratiochangeaftercurativegastrectomyforgastriccancerasubgroupanalysis AT marinaalessandrapereira neutrophillymphocyteratiochangeaftercurativegastrectomyforgastriccancerasubgroupanalysis AT marcusfernandokodamapertilleramos neutrophillymphocyteratiochangeaftercurativegastrectomyforgastriccancerasubgroupanalysis AT brunozilberstein neutrophillymphocyteratiochangeaftercurativegastrectomyforgastriccancerasubgroupanalysis AT ivancecconello neutrophillymphocyteratiochangeaftercurativegastrectomyforgastriccancerasubgroupanalysis AT ulyssesribeirojunior neutrophillymphocyteratiochangeaftercurativegastrectomyforgastriccancerasubgroupanalysis |