Dissection of the gut microbiota in mothers and children with chronic Trichuris trichiura infection in Pemba Island, Tanzania
Abstract Background Soil-transmitted helminthiases are important neglected tropical diseases that result in a notably high number of disability-adjusted life years worldwide. Characterizing the interactions between the human intestinal microbiome and helminths is of interest in the development of al...
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| Format: | Article |
| Language: | English |
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BMC
2021-01-01
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| Series: | Parasites & Vectors |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13071-021-04580-1 |
| _version_ | 1818720183504601088 |
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| author | Hongliang Chen Matteo Mozzicafreddo Elisa Pierella Vanessa Carletti Angela Piersanti Said M. Ali Shaali M. Ame Chunfeng Wang Cristina Miceli |
| author_facet | Hongliang Chen Matteo Mozzicafreddo Elisa Pierella Vanessa Carletti Angela Piersanti Said M. Ali Shaali M. Ame Chunfeng Wang Cristina Miceli |
| author_sort | Hongliang Chen |
| collection | DOAJ |
| description | Abstract Background Soil-transmitted helminthiases are important neglected tropical diseases that result in a notably high number of disability-adjusted life years worldwide. Characterizing the interactions between the human intestinal microbiome and helminths is of interest in the development of alternative treatments that do not rely on chemotherapeutics and do not lead to drug resistance. Methods We recruited and obtained fecal samples from 32 pairs of mothers and children on Pemba Island and monitored their intestinal microbiota using 16S rRNA gene sequencing. Results We observed that microbial changes occur in the gut microbiota of infected mothers and children. Some short-chain fatty acid (SCFA)-producing bacteria and carbohydrate-degrading bacteria exhibited lower abundance in the infected individuals. Potentially pathogenic Campylobacter and proinflammatory Methanobrevibacter in infected mothers and opportunistic Enterococcus in infected children exhibited greater abundance. Conclusions Our findings could reveal the microbiota profiling in T. trichiura-infected individuals, indicate the potential roles of key microbiota in the host and aid to the development of novel strategies to control T. trichiura infection. Graphic abstract |
| first_indexed | 2024-12-17T20:18:47Z |
| format | Article |
| id | doaj.art-6146fdde84154b148a6ba27a2d82e59f |
| institution | Directory Open Access Journal |
| issn | 1756-3305 |
| language | English |
| last_indexed | 2024-12-17T20:18:47Z |
| publishDate | 2021-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Parasites & Vectors |
| spelling | doaj.art-6146fdde84154b148a6ba27a2d82e59f2022-12-21T21:34:00ZengBMCParasites & Vectors1756-33052021-01-0114111310.1186/s13071-021-04580-1Dissection of the gut microbiota in mothers and children with chronic Trichuris trichiura infection in Pemba Island, TanzaniaHongliang Chen0Matteo Mozzicafreddo1Elisa Pierella2Vanessa Carletti3Angela Piersanti4Said M. Ali5Shaali M. Ame6Chunfeng Wang7Cristina Miceli8College of Veterinary Medicine, Jilin Provincial Engineering Research Center of Animal Probiotics, Key Laboratory of Animal Production and Product Quality Safety of Ministry of Education, Jilin Agricultural UniversitySchool of Biosciences and Veterinary Medicine, University of CamerinoSchool of Biosciences and Veterinary Medicine, University of CamerinoSchool of Biosciences and Veterinary Medicine, University of CamerinoSchool of Biosciences and Veterinary Medicine, University of CamerinoPublic Health Laboratory Ivo de CarneriPublic Health Laboratory Ivo de CarneriCollege of Veterinary Medicine, Jilin Provincial Engineering Research Center of Animal Probiotics, Key Laboratory of Animal Production and Product Quality Safety of Ministry of Education, Jilin Agricultural UniversitySchool of Biosciences and Veterinary Medicine, University of CamerinoAbstract Background Soil-transmitted helminthiases are important neglected tropical diseases that result in a notably high number of disability-adjusted life years worldwide. Characterizing the interactions between the human intestinal microbiome and helminths is of interest in the development of alternative treatments that do not rely on chemotherapeutics and do not lead to drug resistance. Methods We recruited and obtained fecal samples from 32 pairs of mothers and children on Pemba Island and monitored their intestinal microbiota using 16S rRNA gene sequencing. Results We observed that microbial changes occur in the gut microbiota of infected mothers and children. Some short-chain fatty acid (SCFA)-producing bacteria and carbohydrate-degrading bacteria exhibited lower abundance in the infected individuals. Potentially pathogenic Campylobacter and proinflammatory Methanobrevibacter in infected mothers and opportunistic Enterococcus in infected children exhibited greater abundance. Conclusions Our findings could reveal the microbiota profiling in T. trichiura-infected individuals, indicate the potential roles of key microbiota in the host and aid to the development of novel strategies to control T. trichiura infection. Graphic abstracthttps://doi.org/10.1186/s13071-021-04580-1Neglected tropical diseaseSoil-transmitted helminthiasesGut microbiota16S rRNA |
| spellingShingle | Hongliang Chen Matteo Mozzicafreddo Elisa Pierella Vanessa Carletti Angela Piersanti Said M. Ali Shaali M. Ame Chunfeng Wang Cristina Miceli Dissection of the gut microbiota in mothers and children with chronic Trichuris trichiura infection in Pemba Island, Tanzania Parasites & Vectors Neglected tropical disease Soil-transmitted helminthiases Gut microbiota 16S rRNA |
| title | Dissection of the gut microbiota in mothers and children with chronic Trichuris trichiura infection in Pemba Island, Tanzania |
| title_full | Dissection of the gut microbiota in mothers and children with chronic Trichuris trichiura infection in Pemba Island, Tanzania |
| title_fullStr | Dissection of the gut microbiota in mothers and children with chronic Trichuris trichiura infection in Pemba Island, Tanzania |
| title_full_unstemmed | Dissection of the gut microbiota in mothers and children with chronic Trichuris trichiura infection in Pemba Island, Tanzania |
| title_short | Dissection of the gut microbiota in mothers and children with chronic Trichuris trichiura infection in Pemba Island, Tanzania |
| title_sort | dissection of the gut microbiota in mothers and children with chronic trichuris trichiura infection in pemba island tanzania |
| topic | Neglected tropical disease Soil-transmitted helminthiases Gut microbiota 16S rRNA |
| url | https://doi.org/10.1186/s13071-021-04580-1 |
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