Advances in Research on the Cardiovascular Complications of Acromegaly
Cardiovascular-related complications are one of the most common complications in patients with acromegaly, and can lead to an increased risk of death. Hypertension and cardiomyopathy are the main cardiovascular complications. The characteristics of acromegalic cardiomyopathy are concentric biventric...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.640999/full |
| _version_ | 1819293732355178496 |
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| author | Han Yang Han Yang Huiwen Tan He Huang Jianwei Li |
| author_facet | Han Yang Han Yang Huiwen Tan He Huang Jianwei Li |
| author_sort | Han Yang |
| collection | DOAJ |
| description | Cardiovascular-related complications are one of the most common complications in patients with acromegaly, and can lead to an increased risk of death. Hypertension and cardiomyopathy are the main cardiovascular complications. The characteristics of acromegalic cardiomyopathy are concentric biventricular hypertrophy and diastolic dysfunction. In addition, arrhythmia and heart valve disease are common cardiac complications in acromegaly. Although the underlying pathophysiology has not been fully elucidated, the spontaneous overproduction of GH and IGF-1, increasing age, prolonged duration of disease and the coexistence of other cardiovascular risk factors are crucial to cardiac complications in patients with acromegaly. Early diagnosis and appropriate treatment of acromegaly might be beneficial for the prevention of cardiomyopathy and premature death. |
| first_indexed | 2024-12-24T04:15:06Z |
| format | Article |
| id | doaj.art-614788db10b0482a9f719a52bc50210d |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-24T04:15:06Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-614788db10b0482a9f719a52bc50210d2022-12-21T17:15:58ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-04-011110.3389/fonc.2021.640999640999Advances in Research on the Cardiovascular Complications of AcromegalyHan Yang0Han Yang1Huiwen Tan2He Huang3Jianwei Li4Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Endocrinology and Metabolism, Chongqing Sixth People’s Hospital, Chongqing, ChinaDepartment of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Cardiology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, ChinaCardiovascular-related complications are one of the most common complications in patients with acromegaly, and can lead to an increased risk of death. Hypertension and cardiomyopathy are the main cardiovascular complications. The characteristics of acromegalic cardiomyopathy are concentric biventricular hypertrophy and diastolic dysfunction. In addition, arrhythmia and heart valve disease are common cardiac complications in acromegaly. Although the underlying pathophysiology has not been fully elucidated, the spontaneous overproduction of GH and IGF-1, increasing age, prolonged duration of disease and the coexistence of other cardiovascular risk factors are crucial to cardiac complications in patients with acromegaly. Early diagnosis and appropriate treatment of acromegaly might be beneficial for the prevention of cardiomyopathy and premature death.https://www.frontiersin.org/articles/10.3389/fonc.2021.640999/fullacromegalyhypertensioncardiomyopathycardiac systolic and diastolic functionechocardiography |
| spellingShingle | Han Yang Han Yang Huiwen Tan He Huang Jianwei Li Advances in Research on the Cardiovascular Complications of Acromegaly Frontiers in Oncology acromegaly hypertension cardiomyopathy cardiac systolic and diastolic function echocardiography |
| title | Advances in Research on the Cardiovascular Complications of Acromegaly |
| title_full | Advances in Research on the Cardiovascular Complications of Acromegaly |
| title_fullStr | Advances in Research on the Cardiovascular Complications of Acromegaly |
| title_full_unstemmed | Advances in Research on the Cardiovascular Complications of Acromegaly |
| title_short | Advances in Research on the Cardiovascular Complications of Acromegaly |
| title_sort | advances in research on the cardiovascular complications of acromegaly |
| topic | acromegaly hypertension cardiomyopathy cardiac systolic and diastolic function echocardiography |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.640999/full |
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