The Ying and Yang of Sphingosine-1-Phosphate Signalling within the Bone
Bone remodelling is a highly active and dynamic process that involves the tight regulation of osteoblasts, osteoclasts, and their progenitors to allow for a balance of bone resorption and formation to be maintained. Ageing and inflammation are risk factors for the dysregulation of bone remodelling....
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/8/6935 |
| _version_ | 1797605153222688768 |
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| author | Kathryn Frost Amy J. Naylor Helen M. McGettrick |
| author_facet | Kathryn Frost Amy J. Naylor Helen M. McGettrick |
| author_sort | Kathryn Frost |
| collection | DOAJ |
| description | Bone remodelling is a highly active and dynamic process that involves the tight regulation of osteoblasts, osteoclasts, and their progenitors to allow for a balance of bone resorption and formation to be maintained. Ageing and inflammation are risk factors for the dysregulation of bone remodelling. Once the balance between bone formation and resorption is lost, bone mass becomes compromised, resulting in disorders such as osteoporosis and Paget’s disease. Key molecules in the sphingosine-1-phosphate signalling pathway have been identified for their role in regulating bone remodelling, in addition to its more recognised role in inflammatory responses. This review discusses the accumulating evidence for the different, and, in certain circumstances, opposing, roles of S1P in bone homeostasis and disease, including osteoporosis, Paget’s disease, and inflammatory bone loss. Specifically, we describe the current, often conflicting, evidence surrounding S1P function in osteoblasts, osteoclasts, and their precursors in health and disease, concluding that S1P may be an effective biomarker of bone disease and also an attractive therapeutic target for disease. |
| first_indexed | 2024-03-11T04:57:04Z |
| format | Article |
| id | doaj.art-6148ea22388c45d1b616b0ba41e864b1 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T04:57:04Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-6148ea22388c45d1b616b0ba41e864b12023-11-17T19:32:41ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-04-01248693510.3390/ijms24086935The Ying and Yang of Sphingosine-1-Phosphate Signalling within the BoneKathryn Frost0Amy J. Naylor1Helen M. McGettrick2Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham B15 2TT, UKRheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham B15 2TT, UKRheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham B15 2TT, UKBone remodelling is a highly active and dynamic process that involves the tight regulation of osteoblasts, osteoclasts, and their progenitors to allow for a balance of bone resorption and formation to be maintained. Ageing and inflammation are risk factors for the dysregulation of bone remodelling. Once the balance between bone formation and resorption is lost, bone mass becomes compromised, resulting in disorders such as osteoporosis and Paget’s disease. Key molecules in the sphingosine-1-phosphate signalling pathway have been identified for their role in regulating bone remodelling, in addition to its more recognised role in inflammatory responses. This review discusses the accumulating evidence for the different, and, in certain circumstances, opposing, roles of S1P in bone homeostasis and disease, including osteoporosis, Paget’s disease, and inflammatory bone loss. Specifically, we describe the current, often conflicting, evidence surrounding S1P function in osteoblasts, osteoclasts, and their precursors in health and disease, concluding that S1P may be an effective biomarker of bone disease and also an attractive therapeutic target for disease.https://www.mdpi.com/1422-0067/24/8/6935osteoblastosteoclastS1Pbone mineral densityboneosteoporosis |
| spellingShingle | Kathryn Frost Amy J. Naylor Helen M. McGettrick The Ying and Yang of Sphingosine-1-Phosphate Signalling within the Bone International Journal of Molecular Sciences osteoblast osteoclast S1P bone mineral density bone osteoporosis |
| title | The Ying and Yang of Sphingosine-1-Phosphate Signalling within the Bone |
| title_full | The Ying and Yang of Sphingosine-1-Phosphate Signalling within the Bone |
| title_fullStr | The Ying and Yang of Sphingosine-1-Phosphate Signalling within the Bone |
| title_full_unstemmed | The Ying and Yang of Sphingosine-1-Phosphate Signalling within the Bone |
| title_short | The Ying and Yang of Sphingosine-1-Phosphate Signalling within the Bone |
| title_sort | ying and yang of sphingosine 1 phosphate signalling within the bone |
| topic | osteoblast osteoclast S1P bone mineral density bone osteoporosis |
| url | https://www.mdpi.com/1422-0067/24/8/6935 |
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