Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism
Mice deficient in the pro-inflammatory cytokine IFNγ have improved glucose tolerance. Here, the authors show that this effect depends on the gut microbeAkkermansia muciniphila, whose abundance increases in the absence IFNγ, and which is known to have beneficial effects on host metabolism.
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13329 |
| _version_ | 1818978599450968064 |
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| author | Renee L. Greer Xiaoxi Dong Ana Carolina F. Moraes Ryszard A. Zielke Gabriel R. Fernandes Ekaterina Peremyslova Stephany Vasquez-Perez Alexi A. Schoenborn Everton P. Gomes Alexandre C. Pereira Sandra R. G. Ferreira Michael Yao Ivan J. Fuss Warren Strober Aleksandra E. Sikora Gregory A. Taylor Ajay S. Gulati Andrey Morgun Natalia Shulzhenko |
| author_facet | Renee L. Greer Xiaoxi Dong Ana Carolina F. Moraes Ryszard A. Zielke Gabriel R. Fernandes Ekaterina Peremyslova Stephany Vasquez-Perez Alexi A. Schoenborn Everton P. Gomes Alexandre C. Pereira Sandra R. G. Ferreira Michael Yao Ivan J. Fuss Warren Strober Aleksandra E. Sikora Gregory A. Taylor Ajay S. Gulati Andrey Morgun Natalia Shulzhenko |
| author_sort | Renee L. Greer |
| collection | DOAJ |
| description | Mice deficient in the pro-inflammatory cytokine IFNγ have improved glucose tolerance. Here, the authors show that this effect depends on the gut microbeAkkermansia muciniphila, whose abundance increases in the absence IFNγ, and which is known to have beneficial effects on host metabolism. |
| first_indexed | 2024-12-20T16:46:12Z |
| format | Article |
| id | doaj.art-61494a965e404846a44ae00fc93376f4 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T16:46:12Z |
| publishDate | 2016-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-61494a965e404846a44ae00fc93376f42022-12-21T19:32:56ZengNature PortfolioNature Communications2041-17232016-11-017111310.1038/ncomms13329Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolismRenee L. Greer0Xiaoxi Dong1Ana Carolina F. Moraes2Ryszard A. Zielke3Gabriel R. Fernandes4Ekaterina Peremyslova5Stephany Vasquez-Perez6Alexi A. Schoenborn7Everton P. Gomes8Alexandre C. Pereira9Sandra R. G. Ferreira10Michael Yao11Ivan J. Fuss12Warren Strober13Aleksandra E. Sikora14Gregory A. Taylor15Ajay S. Gulati16Andrey Morgun17Natalia Shulzhenko18College of Veterinary Medicine, Oregon State UniversityCollege of Pharmacy, Oregon State UniversityDepartment of Epidemiology, School of Public Health, University of São PauloCollege of Pharmacy, Oregon State UniversityOswaldo Cruz Foundation, René Rachou Research CenterCollege of Pharmacy, Oregon State UniversityCollege of Veterinary Medicine, Oregon State UniversityDivision of Pediatric Gastroenterology, University of North Carolina at Chapel HillLaboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical SchoolLaboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical SchoolDepartment of Epidemiology, School of Public Health, University of São PauloMucosal Immunity Section, Laboratory of Immune Defenses, National Institute of Allergy and Infectious DiseasesMucosal Immunity Section, Laboratory of Immune Defenses, National Institute of Allergy and Infectious DiseasesMucosal Immunity Section, Laboratory of Immune Defenses, National Institute of Allergy and Infectious DiseasesCollege of Pharmacy, Oregon State UniversityDepartments of Medicine, Division of Geriatrics and Center for the Study of Aging and Human Development, Geriatric Research, Education and Clinical Center, VA Medical Center, Molecular Genetics and Microbiology and ImmunologyDivision of Pediatric Gastroenterology, University of North Carolina at Chapel HillCollege of Pharmacy, Oregon State UniversityCollege of Veterinary Medicine, Oregon State UniversityMice deficient in the pro-inflammatory cytokine IFNγ have improved glucose tolerance. Here, the authors show that this effect depends on the gut microbeAkkermansia muciniphila, whose abundance increases in the absence IFNγ, and which is known to have beneficial effects on host metabolism.https://doi.org/10.1038/ncomms13329 |
| spellingShingle | Renee L. Greer Xiaoxi Dong Ana Carolina F. Moraes Ryszard A. Zielke Gabriel R. Fernandes Ekaterina Peremyslova Stephany Vasquez-Perez Alexi A. Schoenborn Everton P. Gomes Alexandre C. Pereira Sandra R. G. Ferreira Michael Yao Ivan J. Fuss Warren Strober Aleksandra E. Sikora Gregory A. Taylor Ajay S. Gulati Andrey Morgun Natalia Shulzhenko Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism Nature Communications |
| title | Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism |
| title_full | Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism |
| title_fullStr | Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism |
| title_full_unstemmed | Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism |
| title_short | Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism |
| title_sort | akkermansia muciniphila mediates negative effects of ifnγ on glucose metabolism |
| url | https://doi.org/10.1038/ncomms13329 |
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