PTEN Gene Expression and Tamoxifen-Resistance in Steroid Hormone Receptor Positive Breast Cancer Patients, a cross-sectional study between 2006 and 2016
Introduction: PI3K/Akt/mTOR pathway is important in inducing resistance to hormone therapy in patients with hormone positive breast cancer. One regulator of this pathway is the PTEN gene. This study was performed with aim to compare the expression of PTEN gene in hormone receptor positive breast can...
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| Format: | Article |
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Mashhad University of Medical Sciences
2020-04-01
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| Series: | Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān |
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| Online Access: | https://ijogi.mums.ac.ir/article_15959_cab2aa42b3c28f6f0b76ec35c431d765.pdf |
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| author | Fereshteh Mohammadi Daloyi Noorieh Sharifi Fatemeh Homaei Shandiz Lida Jarahi |
| author_facet | Fereshteh Mohammadi Daloyi Noorieh Sharifi Fatemeh Homaei Shandiz Lida Jarahi |
| author_sort | Fereshteh Mohammadi Daloyi |
| collection | DOAJ |
| description | Introduction: PI3K/Akt/mTOR pathway is important in inducing resistance to hormone therapy in patients with hormone positive breast cancer. One regulator of this pathway is the PTEN gene. This study was performed with aim to compare the expression of PTEN gene in hormone receptor positive breast cancer patients between patients with sensitive and resistant to tamoxifen.
Methods: This cross-sectional and retrospective study was performed on 80 hormone receptor positive breast cancer patients who had referred to oncology clinics of Mashhad University of Medical Sciences from 2006 to 2016. Tissue samples of tamoxifen-sensitive and -resistant patients (recurrence/metastasis occurring during the first 5 years of adjuvant hormone therapy) were immunohistochemically evaluated for PTEN expression. Data were analyzed by SPSS software (version 16) and Independent t-test, U Mann-Whitney and chi-square tests. P<0.05 was considered statistically significant.
Results: In this study, 80 patients were evaluated in two groups of tamoxifen sensitive and resistant. The expression of PTEN in tamoxifen-sensitive and resistant patients was 97.5% and 27.5%, respectively (p=0.001). However, in patients with more advanced lymph node involvement, the expression of PTEN was significantly reduced (p=0.001), there was no significant relationship between PTEN expression and tumor size (p=0.19), tumor grade (p=0.14) and Her2/neu expression (p=0.85).
Conclusion: There is association between PTEN gene expression and tamoxifen resistance. |
| first_indexed | 2024-04-12T11:25:25Z |
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| id | doaj.art-614a2819a527417e95047342ca33d5f4 |
| institution | Directory Open Access Journal |
| issn | 1680-2993 2008-2363 |
| language | fas |
| last_indexed | 2024-04-12T11:25:25Z |
| publishDate | 2020-04-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān |
| spelling | doaj.art-614a2819a527417e95047342ca33d5f42022-12-22T03:35:14ZfasMashhad University of Medical SciencesMajallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān1680-29932008-23632020-04-0123291910.22038/ijogi.2020.1595915959PTEN Gene Expression and Tamoxifen-Resistance in Steroid Hormone Receptor Positive Breast Cancer Patients, a cross-sectional study between 2006 and 2016Fereshteh Mohammadi Daloyi0Noorieh Sharifi1Fatemeh Homaei Shandiz2Lida Jarahi3Resident, Department of Clinic, Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Professor, Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Associate Professor, Department of Radiotherapy and Oncology, Cancer Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Associate Professor, Department of Community Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Introduction: PI3K/Akt/mTOR pathway is important in inducing resistance to hormone therapy in patients with hormone positive breast cancer. One regulator of this pathway is the PTEN gene. This study was performed with aim to compare the expression of PTEN gene in hormone receptor positive breast cancer patients between patients with sensitive and resistant to tamoxifen. Methods: This cross-sectional and retrospective study was performed on 80 hormone receptor positive breast cancer patients who had referred to oncology clinics of Mashhad University of Medical Sciences from 2006 to 2016. Tissue samples of tamoxifen-sensitive and -resistant patients (recurrence/metastasis occurring during the first 5 years of adjuvant hormone therapy) were immunohistochemically evaluated for PTEN expression. Data were analyzed by SPSS software (version 16) and Independent t-test, U Mann-Whitney and chi-square tests. P<0.05 was considered statistically significant. Results: In this study, 80 patients were evaluated in two groups of tamoxifen sensitive and resistant. The expression of PTEN in tamoxifen-sensitive and resistant patients was 97.5% and 27.5%, respectively (p=0.001). However, in patients with more advanced lymph node involvement, the expression of PTEN was significantly reduced (p=0.001), there was no significant relationship between PTEN expression and tumor size (p=0.19), tumor grade (p=0.14) and Her2/neu expression (p=0.85). Conclusion: There is association between PTEN gene expression and tamoxifen resistance.https://ijogi.mums.ac.ir/article_15959_cab2aa42b3c28f6f0b76ec35c431d765.pdfbreast cancersteroid hormone receptor positivetamoxifenhormone therapy resistancepten |
| spellingShingle | Fereshteh Mohammadi Daloyi Noorieh Sharifi Fatemeh Homaei Shandiz Lida Jarahi PTEN Gene Expression and Tamoxifen-Resistance in Steroid Hormone Receptor Positive Breast Cancer Patients, a cross-sectional study between 2006 and 2016 Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān breast cancer steroid hormone receptor positive tamoxifen hormone therapy resistance pten |
| title | PTEN Gene Expression and Tamoxifen-Resistance in Steroid Hormone Receptor Positive Breast Cancer Patients, a cross-sectional study between 2006 and 2016 |
| title_full | PTEN Gene Expression and Tamoxifen-Resistance in Steroid Hormone Receptor Positive Breast Cancer Patients, a cross-sectional study between 2006 and 2016 |
| title_fullStr | PTEN Gene Expression and Tamoxifen-Resistance in Steroid Hormone Receptor Positive Breast Cancer Patients, a cross-sectional study between 2006 and 2016 |
| title_full_unstemmed | PTEN Gene Expression and Tamoxifen-Resistance in Steroid Hormone Receptor Positive Breast Cancer Patients, a cross-sectional study between 2006 and 2016 |
| title_short | PTEN Gene Expression and Tamoxifen-Resistance in Steroid Hormone Receptor Positive Breast Cancer Patients, a cross-sectional study between 2006 and 2016 |
| title_sort | pten gene expression and tamoxifen resistance in steroid hormone receptor positive breast cancer patients a cross sectional study between 2006 and 2016 |
| topic | breast cancer steroid hormone receptor positive tamoxifen hormone therapy resistance pten |
| url | https://ijogi.mums.ac.ir/article_15959_cab2aa42b3c28f6f0b76ec35c431d765.pdf |
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