Angiogenesis and Lymphangiogenesis in Medulloblastoma Development
Medulloblastoma (MB) is the most prevalent brain tumor in children. Although the current cure rate stands at approximately 70%, the existing treatments that involve a combination of radio- and chemotherapy are highly detrimental to the patients’ quality of life. These aggressive therapies often resu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/12/7/1028 |
| _version_ | 1797590165299920896 |
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| author | Manon Penco-Campillo Gilles Pages Sonia Martial |
| author_facet | Manon Penco-Campillo Gilles Pages Sonia Martial |
| author_sort | Manon Penco-Campillo |
| collection | DOAJ |
| description | Medulloblastoma (MB) is the most prevalent brain tumor in children. Although the current cure rate stands at approximately 70%, the existing treatments that involve a combination of radio- and chemotherapy are highly detrimental to the patients’ quality of life. These aggressive therapies often result in a significant reduction in the overall well-being of the patients. Moreover, the most aggressive forms of MB frequently relapse, leading to a fatal outcome in a majority of cases. However, MB is highly vascularized, and both angiogenesis and lymphangiogenesis are believed to play crucial roles in tumor development and spread. In this context, our objective is to provide a comprehensive overview of the current research progress in elucidating the functions of these two pathways. |
| first_indexed | 2024-03-11T01:17:34Z |
| format | Article |
| id | doaj.art-614a2d79996d4d26b98eebb89f5339ec |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-11T01:17:34Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-614a2d79996d4d26b98eebb89f5339ec2023-11-18T18:24:35ZengMDPI AGBiology2079-77372023-07-01127102810.3390/biology12071028Angiogenesis and Lymphangiogenesis in Medulloblastoma DevelopmentManon Penco-Campillo0Gilles Pages1Sonia Martial2Institute for Research on Cancer and Aging (IRCAN), Université Côte d’Azur, CNRS UMR 7284 and INSERM U1081, 33 Avenue de Valombrose, 06107 Nice, FranceInstitute for Research on Cancer and Aging (IRCAN), Université Côte d’Azur, CNRS UMR 7284 and INSERM U1081, 33 Avenue de Valombrose, 06107 Nice, FranceInstitute for Research on Cancer and Aging (IRCAN), Université Côte d’Azur, CNRS UMR 7284 and INSERM U1081, 33 Avenue de Valombrose, 06107 Nice, FranceMedulloblastoma (MB) is the most prevalent brain tumor in children. Although the current cure rate stands at approximately 70%, the existing treatments that involve a combination of radio- and chemotherapy are highly detrimental to the patients’ quality of life. These aggressive therapies often result in a significant reduction in the overall well-being of the patients. Moreover, the most aggressive forms of MB frequently relapse, leading to a fatal outcome in a majority of cases. However, MB is highly vascularized, and both angiogenesis and lymphangiogenesis are believed to play crucial roles in tumor development and spread. In this context, our objective is to provide a comprehensive overview of the current research progress in elucidating the functions of these two pathways.https://www.mdpi.com/2079-7737/12/7/1028medulloblastomachildhoodangiogenesislymphangiogenesismetastasis |
| spellingShingle | Manon Penco-Campillo Gilles Pages Sonia Martial Angiogenesis and Lymphangiogenesis in Medulloblastoma Development Biology medulloblastoma childhood angiogenesis lymphangiogenesis metastasis |
| title | Angiogenesis and Lymphangiogenesis in Medulloblastoma Development |
| title_full | Angiogenesis and Lymphangiogenesis in Medulloblastoma Development |
| title_fullStr | Angiogenesis and Lymphangiogenesis in Medulloblastoma Development |
| title_full_unstemmed | Angiogenesis and Lymphangiogenesis in Medulloblastoma Development |
| title_short | Angiogenesis and Lymphangiogenesis in Medulloblastoma Development |
| title_sort | angiogenesis and lymphangiogenesis in medulloblastoma development |
| topic | medulloblastoma childhood angiogenesis lymphangiogenesis metastasis |
| url | https://www.mdpi.com/2079-7737/12/7/1028 |
| work_keys_str_mv | AT manonpencocampillo angiogenesisandlymphangiogenesisinmedulloblastomadevelopment AT gillespages angiogenesisandlymphangiogenesisinmedulloblastomadevelopment AT soniamartial angiogenesisandlymphangiogenesisinmedulloblastomadevelopment |