Bacterial Outer Membrane Vesicle-Mediated Cytosolic Delivery of Flagellin Triggers Host NLRC4 Canonical Inflammasome Signaling

Bacterial Outer Membrane Vesicle-Mediated Cytosolic Delivery of Flagellin Triggers Host NLRC4 Canonical Inflammasome Signaling

Bacteria-released components can modulate host innate immune response in the absence of direct host cell–bacteria interaction. In particular, bacteria-derived outer membrane vesicles (OMVs) were recently shown to activate host caspase-11-mediated non-canonical inflammasome pathway via deliverance of...

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Bibliographic Details
Main Authors:	Jungmin Yang, Inhwa Hwang, Eunju Lee, Sung Jae Shin, Eun-Jin Lee, Joon Haeng Rhee, Je-Wook Yu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-11-01
Series:	Frontiers in Immunology
Subjects:	outer membrane vesicles NLRC4 inflammasome interleukin-1 caspase-1 flagellin
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2020.581165/full

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