Natural rubber latex used as drug delivery system in guided bone regeneration (GBR)
In this work, we propose natural rubber latex (NRL) membranes as a protein delivery system. For this purpose Bovine Serum Albumin (BSA) was incorporated into the latex solution for in vitro protein delivery experiments. Different polymerization temperatures were used, from -10 to 27 °C, in order to...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Metalurgia e Materiais (ABM); Associação Brasileira de Cerâmica (ABC); Associação Brasileira de Polímeros (ABPol)
2009-06-01
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| Series: | Materials Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392009000200023 |
| _version_ | 1819147348979220480 |
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| author | Rondinelli Donizetti Herculano Cecília Pereira Silva Cibele Ereno Sérgio Augusto Catanzaro Guimaraes Angela Kinoshita Carlos Frederico de Oliveira Graeff |
| author_facet | Rondinelli Donizetti Herculano Cecília Pereira Silva Cibele Ereno Sérgio Augusto Catanzaro Guimaraes Angela Kinoshita Carlos Frederico de Oliveira Graeff |
| author_sort | Rondinelli Donizetti Herculano |
| collection | DOAJ |
| description | In this work, we propose natural rubber latex (NRL) membranes as a protein delivery system. For this purpose Bovine Serum Albumin (BSA) was incorporated into the latex solution for in vitro protein delivery experiments. Different polymerization temperatures were used, from -10 to 27 °C, in order to control the membrane morphology. These membranes were characterized by Scanning Electron Microscopy (SEM), Atomic Force Microscopy (AFM), as well as the Lowry Method to measure the BSA release. SEM and AFM microscopy analysis showed that the number, size and distribution of pores in NRL membranes can be varied, as well as its overall morphology. We have found that the morphology of the membrane is the predominant factor for higher protein release, compared with pore size and number of pores. Results demonstrated that the best drug-delivery system was the membrane polymerized at RT (27 °C), which does release 66% of its BSA content for up to 18 days. Our results indicate that NRLb could be used in the future as an active membrane that could accelerate bone healing in GBR. |
| first_indexed | 2024-12-22T13:28:24Z |
| format | Article |
| id | doaj.art-614bb921ea2f4263a29739b9c8de9c35 |
| institution | Directory Open Access Journal |
| issn | 1516-1439 |
| language | English |
| last_indexed | 2024-12-22T13:28:24Z |
| publishDate | 2009-06-01 |
| publisher | Associação Brasileira de Metalurgia e Materiais (ABM); Associação Brasileira de Cerâmica (ABC); Associação Brasileira de Polímeros (ABPol) |
| record_format | Article |
| series | Materials Research |
| spelling | doaj.art-614bb921ea2f4263a29739b9c8de9c352022-12-21T18:24:14ZengAssociação Brasileira de Metalurgia e Materiais (ABM); Associação Brasileira de Cerâmica (ABC); Associação Brasileira de Polímeros (ABPol)Materials Research1516-14392009-06-0112225325610.1590/S1516-14392009000200023Natural rubber latex used as drug delivery system in guided bone regeneration (GBR)Rondinelli Donizetti HerculanoCecília Pereira SilvaCibele ErenoSérgio Augusto Catanzaro GuimaraesAngela KinoshitaCarlos Frederico de Oliveira GraeffIn this work, we propose natural rubber latex (NRL) membranes as a protein delivery system. For this purpose Bovine Serum Albumin (BSA) was incorporated into the latex solution for in vitro protein delivery experiments. Different polymerization temperatures were used, from -10 to 27 °C, in order to control the membrane morphology. These membranes were characterized by Scanning Electron Microscopy (SEM), Atomic Force Microscopy (AFM), as well as the Lowry Method to measure the BSA release. SEM and AFM microscopy analysis showed that the number, size and distribution of pores in NRL membranes can be varied, as well as its overall morphology. We have found that the morphology of the membrane is the predominant factor for higher protein release, compared with pore size and number of pores. Results demonstrated that the best drug-delivery system was the membrane polymerized at RT (27 °C), which does release 66% of its BSA content for up to 18 days. Our results indicate that NRLb could be used in the future as an active membrane that could accelerate bone healing in GBR.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392009000200023artificial membranebone regenerationbiomaterialsguided bone regenerationlatex |
| spellingShingle | Rondinelli Donizetti Herculano Cecília Pereira Silva Cibele Ereno Sérgio Augusto Catanzaro Guimaraes Angela Kinoshita Carlos Frederico de Oliveira Graeff Natural rubber latex used as drug delivery system in guided bone regeneration (GBR) Materials Research artificial membrane bone regeneration biomaterials guided bone regeneration latex |
| title | Natural rubber latex used as drug delivery system in guided bone regeneration (GBR) |
| title_full | Natural rubber latex used as drug delivery system in guided bone regeneration (GBR) |
| title_fullStr | Natural rubber latex used as drug delivery system in guided bone regeneration (GBR) |
| title_full_unstemmed | Natural rubber latex used as drug delivery system in guided bone regeneration (GBR) |
| title_short | Natural rubber latex used as drug delivery system in guided bone regeneration (GBR) |
| title_sort | natural rubber latex used as drug delivery system in guided bone regeneration gbr |
| topic | artificial membrane bone regeneration biomaterials guided bone regeneration latex |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392009000200023 |
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