Functional biomaterials for comprehensive periodontitis therapy
Periodontitis is an inflammatory disease caused by bacterial infection directly, and the dysregulation of host immune-inflammatory response finally destroys periodontal tissues. Current treatment strategies for periodontitis mainly involve mechanical scaling/root planing (SRP), surgical procedures,...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-06-01
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| Series: | Acta Pharmaceutica Sinica B |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383522004518 |
| _version_ | 1797791876944756736 |
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| author | Jiayi Luan Ruotao Li Weiguo Xu Huiying Sun Qiqi Li Di Wang Shujun Dong Jianxun Ding |
| author_facet | Jiayi Luan Ruotao Li Weiguo Xu Huiying Sun Qiqi Li Di Wang Shujun Dong Jianxun Ding |
| author_sort | Jiayi Luan |
| collection | DOAJ |
| description | Periodontitis is an inflammatory disease caused by bacterial infection directly, and the dysregulation of host immune-inflammatory response finally destroys periodontal tissues. Current treatment strategies for periodontitis mainly involve mechanical scaling/root planing (SRP), surgical procedures, and systemic or localized delivery of antimicrobial agents. However, SRP or surgical treatment alone has unsatisfactory long-term effects and is easy to relapse. In addition, the existing drugs for local periodontal therapy do not stay in the periodontal pocket long enough and have difficulties in maintaining a steady, effective concentration to obtain a therapeutic effect, and continuous administration always causes drug resistance. Many recent studies have shown that adding bio-functional materials and drug delivery systems upregulates the therapeutic effectiveness of periodontitis. This review focuses on the role of biomaterials in periodontitis treatment and presents an overview of antibacterial therapy, host modulatory therapy, periodontal regeneration, and multifunctional regulation of periodontitis therapy. Biomaterials provide advanced approaches for periodontal therapy, and it is foreseeable that further understanding and applications of biomaterials will promote the development of periodontal therapy. |
| first_indexed | 2024-03-13T02:25:04Z |
| format | Article |
| id | doaj.art-614e3a78c3a04bbda4b08532c5689f23 |
| institution | Directory Open Access Journal |
| issn | 2211-3835 |
| language | English |
| last_indexed | 2024-03-13T02:25:04Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj.art-614e3a78c3a04bbda4b08532c5689f232023-06-30T04:21:55ZengElsevierActa Pharmaceutica Sinica B2211-38352023-06-0113623102333Functional biomaterials for comprehensive periodontitis therapyJiayi Luan0Ruotao Li1Weiguo Xu2Huiying Sun3Qiqi Li4Di Wang5Shujun Dong6Jianxun Ding7VIP Integrated Department, Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, School and Hospital of Stomatology, Jilin University, Changchun 130021, ChinaDepartment of Hand and Foot Surgery, the First Hospital of Jilin University, Changchun 130061, ChinaKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, ChinaVIP Integrated Department, Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, School and Hospital of Stomatology, Jilin University, Changchun 130021, ChinaVIP Integrated Department, Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, School and Hospital of Stomatology, Jilin University, Changchun 130021, ChinaVIP Integrated Department, Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, School and Hospital of Stomatology, Jilin University, Changchun 130021, ChinaVIP Integrated Department, Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, School and Hospital of Stomatology, Jilin University, Changchun 130021, China; Corresponding authors.Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; Corresponding authors.Periodontitis is an inflammatory disease caused by bacterial infection directly, and the dysregulation of host immune-inflammatory response finally destroys periodontal tissues. Current treatment strategies for periodontitis mainly involve mechanical scaling/root planing (SRP), surgical procedures, and systemic or localized delivery of antimicrobial agents. However, SRP or surgical treatment alone has unsatisfactory long-term effects and is easy to relapse. In addition, the existing drugs for local periodontal therapy do not stay in the periodontal pocket long enough and have difficulties in maintaining a steady, effective concentration to obtain a therapeutic effect, and continuous administration always causes drug resistance. Many recent studies have shown that adding bio-functional materials and drug delivery systems upregulates the therapeutic effectiveness of periodontitis. This review focuses on the role of biomaterials in periodontitis treatment and presents an overview of antibacterial therapy, host modulatory therapy, periodontal regeneration, and multifunctional regulation of periodontitis therapy. Biomaterials provide advanced approaches for periodontal therapy, and it is foreseeable that further understanding and applications of biomaterials will promote the development of periodontal therapy.http://www.sciencedirect.com/science/article/pii/S2211383522004518BiomaterialAntibacterial effectHost modulationPeriodontal regenerationPeriodontitis therapyAnti-oxidant |
| spellingShingle | Jiayi Luan Ruotao Li Weiguo Xu Huiying Sun Qiqi Li Di Wang Shujun Dong Jianxun Ding Functional biomaterials for comprehensive periodontitis therapy Acta Pharmaceutica Sinica B Biomaterial Antibacterial effect Host modulation Periodontal regeneration Periodontitis therapy Anti-oxidant |
| title | Functional biomaterials for comprehensive periodontitis therapy |
| title_full | Functional biomaterials for comprehensive periodontitis therapy |
| title_fullStr | Functional biomaterials for comprehensive periodontitis therapy |
| title_full_unstemmed | Functional biomaterials for comprehensive periodontitis therapy |
| title_short | Functional biomaterials for comprehensive periodontitis therapy |
| title_sort | functional biomaterials for comprehensive periodontitis therapy |
| topic | Biomaterial Antibacterial effect Host modulation Periodontal regeneration Periodontitis therapy Anti-oxidant |
| url | http://www.sciencedirect.com/science/article/pii/S2211383522004518 |
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