Von Willebrand Factor, Factor VIII, and Other Acute Phase Reactants as Biomarkers of Inflammation and Endothelial Dysfunction in Chronic Graft-Versus-Host Disease
Chronic graft-versus-host disease (cGvHD) is an immune mediated late complication of allogeneic hematopoietic stem cell transplantation (alloHSCT). Discovery of adequate biomarkers could identify high-risk patients and provide an effective pre-emptive intervention or early modification of therapeuti...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-04-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.676756/full |
| _version_ | 1818953688785354752 |
|---|---|
| author | Antonela Lelas Hildegard Theresia Greinix Daniel Wolff Günther Eissner Steven Zivko Pavletic Drazen Pulanic Drazen Pulanic |
| author_facet | Antonela Lelas Hildegard Theresia Greinix Daniel Wolff Günther Eissner Steven Zivko Pavletic Drazen Pulanic Drazen Pulanic |
| author_sort | Antonela Lelas |
| collection | DOAJ |
| description | Chronic graft-versus-host disease (cGvHD) is an immune mediated late complication of allogeneic hematopoietic stem cell transplantation (alloHSCT). Discovery of adequate biomarkers could identify high-risk patients and provide an effective pre-emptive intervention or early modification of therapeutic strategy, thus reducing prevalence and severity of the disease among long-term survivors of alloHSCT. Inflammation, endothelial injury, and endothelial dysfunction are involved in cGvHD development. Altered levels of acute phase reactants have shown a strong correlation with the activity of several immune mediated disorders and are routinely used in clinical practice. Since elevated von Willebrand factor (VWF) and factor VIII (FVIII) levels have been described as acute phase reactants that may indicate endothelial dysfunction and inflammation in different settings, including chronic autoimmune diseases, they could serve as potential candidate biomarkers of cGvHD. In this review we focused on reported data regarding VWF and FVIII as well as other markers of inflammation and endothelial dysfunction, evaluating their potential role in cGvHD. |
| first_indexed | 2024-12-20T10:10:15Z |
| format | Article |
| id | doaj.art-6150901f3dcc4f22bfe0156292d4a283 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-20T10:10:15Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-6150901f3dcc4f22bfe0156292d4a2832022-12-21T19:44:11ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-04-011210.3389/fimmu.2021.676756676756Von Willebrand Factor, Factor VIII, and Other Acute Phase Reactants as Biomarkers of Inflammation and Endothelial Dysfunction in Chronic Graft-Versus-Host DiseaseAntonela Lelas0Hildegard Theresia Greinix1Daniel Wolff2Günther Eissner3Steven Zivko Pavletic4Drazen Pulanic5Drazen Pulanic6Division of Hematology, Department of Internal Medicine, University Hospital Centre Zagreb, Zagreb, CroatiaDivision of Hematology, Medical University of Graz, Graz, AustriaDepartment of Internal Medicine III, University Hospital Regensburg, Regensburg, GermanySystems Biology Ireland, School of Medicine, Conway Institute, University College Dublin, Dublin, IrelandCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United StatesDivision of Hematology, Department of Internal Medicine, University Hospital Centre Zagreb, Zagreb, CroatiaSchool of Medicine, University of Zagreb, Zagreb, CroatiaChronic graft-versus-host disease (cGvHD) is an immune mediated late complication of allogeneic hematopoietic stem cell transplantation (alloHSCT). Discovery of adequate biomarkers could identify high-risk patients and provide an effective pre-emptive intervention or early modification of therapeutic strategy, thus reducing prevalence and severity of the disease among long-term survivors of alloHSCT. Inflammation, endothelial injury, and endothelial dysfunction are involved in cGvHD development. Altered levels of acute phase reactants have shown a strong correlation with the activity of several immune mediated disorders and are routinely used in clinical practice. Since elevated von Willebrand factor (VWF) and factor VIII (FVIII) levels have been described as acute phase reactants that may indicate endothelial dysfunction and inflammation in different settings, including chronic autoimmune diseases, they could serve as potential candidate biomarkers of cGvHD. In this review we focused on reported data regarding VWF and FVIII as well as other markers of inflammation and endothelial dysfunction, evaluating their potential role in cGvHD.https://www.frontiersin.org/articles/10.3389/fimmu.2021.676756/fullendothelial dysfunctioninflammationfactor VIIIVon Willeband factorchronic graft-versus-host disease (cGvHD)allogeneic hematopoietic stem cell transplantation |
| spellingShingle | Antonela Lelas Hildegard Theresia Greinix Daniel Wolff Günther Eissner Steven Zivko Pavletic Drazen Pulanic Drazen Pulanic Von Willebrand Factor, Factor VIII, and Other Acute Phase Reactants as Biomarkers of Inflammation and Endothelial Dysfunction in Chronic Graft-Versus-Host Disease Frontiers in Immunology endothelial dysfunction inflammation factor VIII Von Willeband factor chronic graft-versus-host disease (cGvHD) allogeneic hematopoietic stem cell transplantation |
| title | Von Willebrand Factor, Factor VIII, and Other Acute Phase Reactants as Biomarkers of Inflammation and Endothelial Dysfunction in Chronic Graft-Versus-Host Disease |
| title_full | Von Willebrand Factor, Factor VIII, and Other Acute Phase Reactants as Biomarkers of Inflammation and Endothelial Dysfunction in Chronic Graft-Versus-Host Disease |
| title_fullStr | Von Willebrand Factor, Factor VIII, and Other Acute Phase Reactants as Biomarkers of Inflammation and Endothelial Dysfunction in Chronic Graft-Versus-Host Disease |
| title_full_unstemmed | Von Willebrand Factor, Factor VIII, and Other Acute Phase Reactants as Biomarkers of Inflammation and Endothelial Dysfunction in Chronic Graft-Versus-Host Disease |
| title_short | Von Willebrand Factor, Factor VIII, and Other Acute Phase Reactants as Biomarkers of Inflammation and Endothelial Dysfunction in Chronic Graft-Versus-Host Disease |
| title_sort | von willebrand factor factor viii and other acute phase reactants as biomarkers of inflammation and endothelial dysfunction in chronic graft versus host disease |
| topic | endothelial dysfunction inflammation factor VIII Von Willeband factor chronic graft-versus-host disease (cGvHD) allogeneic hematopoietic stem cell transplantation |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.676756/full |
| work_keys_str_mv | AT antonelalelas vonwillebrandfactorfactorviiiandotheracutephasereactantsasbiomarkersofinflammationandendothelialdysfunctioninchronicgraftversushostdisease AT hildegardtheresiagreinix vonwillebrandfactorfactorviiiandotheracutephasereactantsasbiomarkersofinflammationandendothelialdysfunctioninchronicgraftversushostdisease AT danielwolff vonwillebrandfactorfactorviiiandotheracutephasereactantsasbiomarkersofinflammationandendothelialdysfunctioninchronicgraftversushostdisease AT gunthereissner vonwillebrandfactorfactorviiiandotheracutephasereactantsasbiomarkersofinflammationandendothelialdysfunctioninchronicgraftversushostdisease AT stevenzivkopavletic vonwillebrandfactorfactorviiiandotheracutephasereactantsasbiomarkersofinflammationandendothelialdysfunctioninchronicgraftversushostdisease AT drazenpulanic vonwillebrandfactorfactorviiiandotheracutephasereactantsasbiomarkersofinflammationandendothelialdysfunctioninchronicgraftversushostdisease AT drazenpulanic vonwillebrandfactorfactorviiiandotheracutephasereactantsasbiomarkersofinflammationandendothelialdysfunctioninchronicgraftversushostdisease |