The association between the reduction of body weight and new-onset type 2 diabetes remission in middle-aged Japanese men: Population-based Panasonic cohort study 8
AimThis study aimed to investigate the association between change in body weight (BW) and type 2 diabetes remission in Japanese men with new-onset type 2 diabetes.MethodsThis study enrolled 1,903 patients with new-onset type 2 diabetes between 2008 and 2013 from a medical health checkup program cond...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1019390/full |
| _version_ | 1828063268263952384 |
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| author | Takaaki Matsui Hiroshi Okada Hiroshi Okada Masahide Hamaguchi Kazushiro Kurogi Hiroaki Murata Masato Ito Michiaki Fukui |
| author_facet | Takaaki Matsui Hiroshi Okada Hiroshi Okada Masahide Hamaguchi Kazushiro Kurogi Hiroaki Murata Masato Ito Michiaki Fukui |
| author_sort | Takaaki Matsui |
| collection | DOAJ |
| description | AimThis study aimed to investigate the association between change in body weight (BW) and type 2 diabetes remission in Japanese men with new-onset type 2 diabetes.MethodsThis study enrolled 1,903 patients with new-onset type 2 diabetes between 2008 and 2013 from a medical health checkup program conducted by the Panasonic Corporation, Osaka, Japan. The baseline was defined as the year of new-onset diabetes. We assessed the type 2 diabetes remission five years after baseline and the association between the change in BW and type 2 diabetes remission using logistic regression analyses. To evaluate the predictive performance of the change in BW, we employed the receiver operating characteristic curves and the area under the receiver operating characteristic (ROC) curve (AUC).ResultsThe BW loss was associated with type 2 diabetes remission in the participants with a BMI ≥25 kg/m2 but not in the participants with a BMI <25 kg/m2. The odds ratios were 1.96 (95% CI: 1.19–3.29) and 3.72 (95% CI: 2.14–6.59) in the participants with a loss of 5–9.9% and loss of ≥10% for five years, respectively, in the participants with a BMI ≥25 kg/m2 (reference; stable group [0.9% gain to 0.9% loss]). The AUC and cut-off values for the rate of change in BW for type 2 diabetes remission were 0.59 and 5.0%.DiscussionBody weight loss of ≥5% effectively achieved diabetes remission in Japanese men with a BMI ≥25 kg/m2 and new-onset type 2 diabetes. |
| first_indexed | 2024-04-10T22:41:38Z |
| format | Article |
| id | doaj.art-6150cd46a7714b89bf414ab61b521846 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-10T22:41:38Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-6150cd46a7714b89bf414ab61b5218462023-01-16T04:57:12ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-01-011310.3389/fendo.2022.10193901019390The association between the reduction of body weight and new-onset type 2 diabetes remission in middle-aged Japanese men: Population-based Panasonic cohort study 8Takaaki Matsui0Hiroshi Okada1Hiroshi Okada2Masahide Hamaguchi3Kazushiro Kurogi4Hiroaki Murata5Masato Ito6Michiaki Fukui7Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, JapanDepartment of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, JapanDepartment of Diabetes and Endocrinology, Matsushita Memorial Hospital, Moriguchi, JapanDepartment of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, JapanDepartment of Health Care Center, Panasonic Health Insurance Organization, Moriguchi, JapanDepartment of Orthopaedic Surgery, Matsushita Memorial Hospital, Moriguchi, JapanDepartment of Health Care Center, Panasonic Health Insurance Organization, Moriguchi, JapanDepartment of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, JapanAimThis study aimed to investigate the association between change in body weight (BW) and type 2 diabetes remission in Japanese men with new-onset type 2 diabetes.MethodsThis study enrolled 1,903 patients with new-onset type 2 diabetes between 2008 and 2013 from a medical health checkup program conducted by the Panasonic Corporation, Osaka, Japan. The baseline was defined as the year of new-onset diabetes. We assessed the type 2 diabetes remission five years after baseline and the association between the change in BW and type 2 diabetes remission using logistic regression analyses. To evaluate the predictive performance of the change in BW, we employed the receiver operating characteristic curves and the area under the receiver operating characteristic (ROC) curve (AUC).ResultsThe BW loss was associated with type 2 diabetes remission in the participants with a BMI ≥25 kg/m2 but not in the participants with a BMI <25 kg/m2. The odds ratios were 1.96 (95% CI: 1.19–3.29) and 3.72 (95% CI: 2.14–6.59) in the participants with a loss of 5–9.9% and loss of ≥10% for five years, respectively, in the participants with a BMI ≥25 kg/m2 (reference; stable group [0.9% gain to 0.9% loss]). The AUC and cut-off values for the rate of change in BW for type 2 diabetes remission were 0.59 and 5.0%.DiscussionBody weight loss of ≥5% effectively achieved diabetes remission in Japanese men with a BMI ≥25 kg/m2 and new-onset type 2 diabetes.https://www.frontiersin.org/articles/10.3389/fendo.2022.1019390/fulltype 2 diabetesbody weight lossdiabetes remissionmedical health checkupobesity |
| spellingShingle | Takaaki Matsui Hiroshi Okada Hiroshi Okada Masahide Hamaguchi Kazushiro Kurogi Hiroaki Murata Masato Ito Michiaki Fukui The association between the reduction of body weight and new-onset type 2 diabetes remission in middle-aged Japanese men: Population-based Panasonic cohort study 8 Frontiers in Endocrinology type 2 diabetes body weight loss diabetes remission medical health checkup obesity |
| title | The association between the reduction of body weight and new-onset type 2 diabetes remission in middle-aged Japanese men: Population-based Panasonic cohort study 8 |
| title_full | The association between the reduction of body weight and new-onset type 2 diabetes remission in middle-aged Japanese men: Population-based Panasonic cohort study 8 |
| title_fullStr | The association between the reduction of body weight and new-onset type 2 diabetes remission in middle-aged Japanese men: Population-based Panasonic cohort study 8 |
| title_full_unstemmed | The association between the reduction of body weight and new-onset type 2 diabetes remission in middle-aged Japanese men: Population-based Panasonic cohort study 8 |
| title_short | The association between the reduction of body weight and new-onset type 2 diabetes remission in middle-aged Japanese men: Population-based Panasonic cohort study 8 |
| title_sort | association between the reduction of body weight and new onset type 2 diabetes remission in middle aged japanese men population based panasonic cohort study 8 |
| topic | type 2 diabetes body weight loss diabetes remission medical health checkup obesity |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1019390/full |
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