A Vascular-Centric Approach to Autism Spectrum Disorders
Brain development and function are highly reliant on adequate establishment and maintenance of vascular networks. Early impairments in vascular health can impact brain maturation and energy metabolism, which may lead to neurodevelopmental anomalies. Our recent work not only provides novel insights i...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2024-03-01
|
| Series: | Neuroscience Insights |
| Online Access: | https://doi.org/10.1177/26331055241235921 |
| _version_ | 1827320205262454784 |
|---|---|
| author | Julie Ouellette Elizabeth E Crouch Jean-Luc Morel Vanessa Coelho-Santos Baptiste Lacoste |
| author_facet | Julie Ouellette Elizabeth E Crouch Jean-Luc Morel Vanessa Coelho-Santos Baptiste Lacoste |
| author_sort | Julie Ouellette |
| collection | DOAJ |
| description | Brain development and function are highly reliant on adequate establishment and maintenance of vascular networks. Early impairments in vascular health can impact brain maturation and energy metabolism, which may lead to neurodevelopmental anomalies. Our recent work not only provides novel insights into the development of cerebrovascular networks but also emphasizes the importance of their well-being for proper brain maturation. In particular, we have demonstrated that endothelial dysfunction in autism spectrum disorders (ASD) mouse models is causally related to altered behavior and brain metabolism. In the prenatal human brain, vascular cells change metabolic states in the second trimester. Such findings highlight the need to identify new cellular and molecular players in neurodevelopmental disorders, raising awareness about the importance of a healthy vasculature for brain development. It is thus essential to shift the mostly neuronal point of view in research on ASD and other neurodevelopmental disorders to also include vascular and metabolic features. |
| first_indexed | 2024-04-25T00:40:42Z |
| format | Article |
| id | doaj.art-61511e21faa145fba3e94c810c491a6e |
| institution | Directory Open Access Journal |
| issn | 2633-1055 |
| language | English |
| last_indexed | 2024-04-25T00:40:42Z |
| publishDate | 2024-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Neuroscience Insights |
| spelling | doaj.art-61511e21faa145fba3e94c810c491a6e2024-03-12T09:03:19ZengSAGE PublishingNeuroscience Insights2633-10552024-03-011910.1177/26331055241235921A Vascular-Centric Approach to Autism Spectrum DisordersJulie Ouellette0Elizabeth E Crouch1Jean-Luc Morel2Vanessa Coelho-Santos3Baptiste Lacoste4Faculty of Medicine, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, CanadaThe Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USAUniversity Bordeaux, CNRS, IMN, UMR 5293, Bordeaux, FranceFaculty of Medicine, Institute of Physiology, University of Coimbra, Coimbra, PortugalUniversity of Ottawa Brain and Mind Research Institute, Ottawa, ON, CanadaBrain development and function are highly reliant on adequate establishment and maintenance of vascular networks. Early impairments in vascular health can impact brain maturation and energy metabolism, which may lead to neurodevelopmental anomalies. Our recent work not only provides novel insights into the development of cerebrovascular networks but also emphasizes the importance of their well-being for proper brain maturation. In particular, we have demonstrated that endothelial dysfunction in autism spectrum disorders (ASD) mouse models is causally related to altered behavior and brain metabolism. In the prenatal human brain, vascular cells change metabolic states in the second trimester. Such findings highlight the need to identify new cellular and molecular players in neurodevelopmental disorders, raising awareness about the importance of a healthy vasculature for brain development. It is thus essential to shift the mostly neuronal point of view in research on ASD and other neurodevelopmental disorders to also include vascular and metabolic features.https://doi.org/10.1177/26331055241235921 |
| spellingShingle | Julie Ouellette Elizabeth E Crouch Jean-Luc Morel Vanessa Coelho-Santos Baptiste Lacoste A Vascular-Centric Approach to Autism Spectrum Disorders Neuroscience Insights |
| title | A Vascular-Centric Approach to Autism Spectrum Disorders |
| title_full | A Vascular-Centric Approach to Autism Spectrum Disorders |
| title_fullStr | A Vascular-Centric Approach to Autism Spectrum Disorders |
| title_full_unstemmed | A Vascular-Centric Approach to Autism Spectrum Disorders |
| title_short | A Vascular-Centric Approach to Autism Spectrum Disorders |
| title_sort | vascular centric approach to autism spectrum disorders |
| url | https://doi.org/10.1177/26331055241235921 |
| work_keys_str_mv | AT julieouellette avascularcentricapproachtoautismspectrumdisorders AT elizabethecrouch avascularcentricapproachtoautismspectrumdisorders AT jeanlucmorel avascularcentricapproachtoautismspectrumdisorders AT vanessacoelhosantos avascularcentricapproachtoautismspectrumdisorders AT baptistelacoste avascularcentricapproachtoautismspectrumdisorders AT julieouellette vascularcentricapproachtoautismspectrumdisorders AT elizabethecrouch vascularcentricapproachtoautismspectrumdisorders AT jeanlucmorel vascularcentricapproachtoautismspectrumdisorders AT vanessacoelhosantos vascularcentricapproachtoautismspectrumdisorders AT baptistelacoste vascularcentricapproachtoautismspectrumdisorders |