Levodopa versus non-levodopa brain language fMRI in Parkinson's disease
OBJECTIVE: To identify the effect of levodopa in language areas in Parkinson's disease patients. METHODS: We evaluated 50 patients with mild to moderate Parkinson's disease, age and gender paired to 47 healthy volunteers. We selected two homogeneous groups of 18 patients taking levodopa an...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Instituto Israelita de Ensino e Pesquisa Albert Einstein
|
| Series: | Einstein (São Paulo) |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082012000200010&lng=en&tlng=en |
| _version_ | 1818601421166084096 |
|---|---|
| author | Paula Ricci Arantes Heloise Helena Gobato Bárbara Bordegatto Davoglio Maria Ângela Maramaldo Barreiros André Carvalho Felício Orlando Graziani Povoas Barsottini Luiz Augusto Franco de Andrade Edson Amaro Junior |
| author_facet | Paula Ricci Arantes Heloise Helena Gobato Bárbara Bordegatto Davoglio Maria Ângela Maramaldo Barreiros André Carvalho Felício Orlando Graziani Povoas Barsottini Luiz Augusto Franco de Andrade Edson Amaro Junior |
| author_sort | Paula Ricci Arantes |
| collection | DOAJ |
| description | OBJECTIVE: To identify the effect of levodopa in language areas in Parkinson's disease patients. METHODS: We evaluated 50 patients with mild to moderate Parkinson's disease, age and gender paired to 47 healthy volunteers. We selected two homogeneous groups of 18 patients taking levodopa and 7 no levodopa patients. The functional magnetic resonance imaging verbal fluency task, with low and high cognitive demands, was performed at a 3T magnetic resonance imaging equipment. Data was analyzed with XBAM software for group maps and ANOVA comparison. RESULTS: Patients without levodopa had more activation than the ones with levodopa in the medial frontal and in the left frontal and parieto-occipital areas. The striatal activation in patients taking levodopa had similar result of the activation detected in the healthy volunteer group. Parieto-occipital areas were less activated in the levodopa group than in the no levodopa one. CONCLUSION: Parkinson's disease patients without levodopa replacement, during a verbal fluency effort, had more diffuse and intense cerebral activation in left hemisphere, mainly in the frontal and parieto-occipital areas. The striatal activation in verbal fluency of patients with levodopa intake was more similar to the activation found in healthy volunteers. These initial evidences suggested a role of levodopa inhibiting activation in parieto-occipital compensating areas. |
| first_indexed | 2024-12-16T12:51:07Z |
| format | Article |
| id | doaj.art-6151f25b4b7041c9bfbc0bfa1fc7fa92 |
| institution | Directory Open Access Journal |
| issn | 1679-4508 2317-6385 |
| language | English |
| last_indexed | 2024-12-16T12:51:07Z |
| publisher | Instituto Israelita de Ensino e Pesquisa Albert Einstein |
| record_format | Article |
| series | Einstein (São Paulo) |
| spelling | doaj.art-6151f25b4b7041c9bfbc0bfa1fc7fa922022-12-21T22:31:09ZengInstituto Israelita de Ensino e Pesquisa Albert EinsteinEinstein (São Paulo)1679-45082317-638510217117910.1590/S1679-45082012000200010S1679-45082012000200010Levodopa versus non-levodopa brain language fMRI in Parkinson's diseasePaula Ricci Arantes0Heloise Helena Gobato1Bárbara Bordegatto Davoglio2Maria Ângela Maramaldo Barreiros3André Carvalho Felício4Orlando Graziani Povoas Barsottini5Luiz Augusto Franco de Andrade6Edson Amaro Junior7Hospital Israelita Albert EinsteinHospital Israelita Albert EinsteinHospital Israelita Albert EinsteinHospital Israelita Albert EinsteinHospital Israelita Albert EinsteinHospital Israelita Albert EinsteinHospital Israelita Albert EinsteinHospital Israelita Albert EinsteinOBJECTIVE: To identify the effect of levodopa in language areas in Parkinson's disease patients. METHODS: We evaluated 50 patients with mild to moderate Parkinson's disease, age and gender paired to 47 healthy volunteers. We selected two homogeneous groups of 18 patients taking levodopa and 7 no levodopa patients. The functional magnetic resonance imaging verbal fluency task, with low and high cognitive demands, was performed at a 3T magnetic resonance imaging equipment. Data was analyzed with XBAM software for group maps and ANOVA comparison. RESULTS: Patients without levodopa had more activation than the ones with levodopa in the medial frontal and in the left frontal and parieto-occipital areas. The striatal activation in patients taking levodopa had similar result of the activation detected in the healthy volunteer group. Parieto-occipital areas were less activated in the levodopa group than in the no levodopa one. CONCLUSION: Parkinson's disease patients without levodopa replacement, during a verbal fluency effort, had more diffuse and intense cerebral activation in left hemisphere, mainly in the frontal and parieto-occipital areas. The striatal activation in verbal fluency of patients with levodopa intake was more similar to the activation found in healthy volunteers. These initial evidences suggested a role of levodopa inhibiting activation in parieto-occipital compensating areas.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082012000200010&lng=en&tlng=enparkinson diseaselanguagelevodopafunctional magnetic resonance imagingverbal fluency |
| spellingShingle | Paula Ricci Arantes Heloise Helena Gobato Bárbara Bordegatto Davoglio Maria Ângela Maramaldo Barreiros André Carvalho Felício Orlando Graziani Povoas Barsottini Luiz Augusto Franco de Andrade Edson Amaro Junior Levodopa versus non-levodopa brain language fMRI in Parkinson's disease Einstein (São Paulo) parkinson disease language levodopa functional magnetic resonance imaging verbal fluency |
| title | Levodopa versus non-levodopa brain language fMRI in Parkinson's disease |
| title_full | Levodopa versus non-levodopa brain language fMRI in Parkinson's disease |
| title_fullStr | Levodopa versus non-levodopa brain language fMRI in Parkinson's disease |
| title_full_unstemmed | Levodopa versus non-levodopa brain language fMRI in Parkinson's disease |
| title_short | Levodopa versus non-levodopa brain language fMRI in Parkinson's disease |
| title_sort | levodopa versus non levodopa brain language fmri in parkinson s disease |
| topic | parkinson disease language levodopa functional magnetic resonance imaging verbal fluency |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082012000200010&lng=en&tlng=en |
| work_keys_str_mv | AT paularicciarantes levodopaversusnonlevodopabrainlanguagefmriinparkinsonsdisease AT heloisehelenagobato levodopaversusnonlevodopabrainlanguagefmriinparkinsonsdisease AT barbarabordegattodavoglio levodopaversusnonlevodopabrainlanguagefmriinparkinsonsdisease AT mariaangelamaramaldobarreiros levodopaversusnonlevodopabrainlanguagefmriinparkinsonsdisease AT andrecarvalhofelicio levodopaversusnonlevodopabrainlanguagefmriinparkinsonsdisease AT orlandograzianipovoasbarsottini levodopaversusnonlevodopabrainlanguagefmriinparkinsonsdisease AT luizaugustofrancodeandrade levodopaversusnonlevodopabrainlanguagefmriinparkinsonsdisease AT edsonamarojunior levodopaversusnonlevodopabrainlanguagefmriinparkinsonsdisease |