Investigation into potential mechanisms of metabolic syndrome by integrative analysis of metabolomics and proteomics.
Metabolic syndrome (MetS) is a complex syndrome cluster of metabolic disorders, which greatly increases the risks of diabetic and cardiovascular diseases. Although it has become a significantly worldwide public health burden, its pathogenesis largely remains unknown. In this study, we first performe...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0270593 |
| _version_ | 1818002513060691968 |
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| author | Meimei Chen Zhaoyang Yang Huijian Gan Yang Wang Chandong Li Yuxing Gao |
| author_facet | Meimei Chen Zhaoyang Yang Huijian Gan Yang Wang Chandong Li Yuxing Gao |
| author_sort | Meimei Chen |
| collection | DOAJ |
| description | Metabolic syndrome (MetS) is a complex syndrome cluster of metabolic disorders, which greatly increases the risks of diabetic and cardiovascular diseases. Although it has become a significantly worldwide public health burden, its pathogenesis largely remains unknown. In this study, we first performed an integrated analysis of proteomic and metabonomic data of liver tissues of rats between MetS and control groups to reveal possible mechanisms of MetS. A total of 16 significantly perturbed pathways were identified, of which three pathways were shared by patients with MetS and diabetes identified by analysis of serum samples, including alanine, aspartate and glutamate metabolism, valine, leucine and isoleucine biosynthesis, and glycine, serine and threonine metabolism. Additionally, it was found that 18 differential metabolites were closely related with 36 differential proteins, which were considered as significantly discriminant metabolites and proteins between two groups and were mainly involved in metabolic processes of gamma-aminobutyric acid and acetyl-CoA, biosynthetic processes of cholesterol and amino acids. The results of PPI network analysis and topological parameter calculation of four methods revealed that 16 proteins can serve as hub proteins of MetS. Followed by searching the PubMed database and molecular docking of Cyp7a1 and Got1, we concluded that atorvastatin and resveratrol may be potential drugs for MetS. |
| first_indexed | 2024-04-14T03:46:47Z |
| format | Article |
| id | doaj.art-61535a2e0f7e4c9cb89f845c3830379e |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-14T03:46:47Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-61535a2e0f7e4c9cb89f845c3830379e2022-12-22T02:14:13ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01177e027059310.1371/journal.pone.0270593Investigation into potential mechanisms of metabolic syndrome by integrative analysis of metabolomics and proteomics.Meimei ChenZhaoyang YangHuijian GanYang WangChandong LiYuxing GaoMetabolic syndrome (MetS) is a complex syndrome cluster of metabolic disorders, which greatly increases the risks of diabetic and cardiovascular diseases. Although it has become a significantly worldwide public health burden, its pathogenesis largely remains unknown. In this study, we first performed an integrated analysis of proteomic and metabonomic data of liver tissues of rats between MetS and control groups to reveal possible mechanisms of MetS. A total of 16 significantly perturbed pathways were identified, of which three pathways were shared by patients with MetS and diabetes identified by analysis of serum samples, including alanine, aspartate and glutamate metabolism, valine, leucine and isoleucine biosynthesis, and glycine, serine and threonine metabolism. Additionally, it was found that 18 differential metabolites were closely related with 36 differential proteins, which were considered as significantly discriminant metabolites and proteins between two groups and were mainly involved in metabolic processes of gamma-aminobutyric acid and acetyl-CoA, biosynthetic processes of cholesterol and amino acids. The results of PPI network analysis and topological parameter calculation of four methods revealed that 16 proteins can serve as hub proteins of MetS. Followed by searching the PubMed database and molecular docking of Cyp7a1 and Got1, we concluded that atorvastatin and resveratrol may be potential drugs for MetS.https://doi.org/10.1371/journal.pone.0270593 |
| spellingShingle | Meimei Chen Zhaoyang Yang Huijian Gan Yang Wang Chandong Li Yuxing Gao Investigation into potential mechanisms of metabolic syndrome by integrative analysis of metabolomics and proteomics. PLoS ONE |
| title | Investigation into potential mechanisms of metabolic syndrome by integrative analysis of metabolomics and proteomics. |
| title_full | Investigation into potential mechanisms of metabolic syndrome by integrative analysis of metabolomics and proteomics. |
| title_fullStr | Investigation into potential mechanisms of metabolic syndrome by integrative analysis of metabolomics and proteomics. |
| title_full_unstemmed | Investigation into potential mechanisms of metabolic syndrome by integrative analysis of metabolomics and proteomics. |
| title_short | Investigation into potential mechanisms of metabolic syndrome by integrative analysis of metabolomics and proteomics. |
| title_sort | investigation into potential mechanisms of metabolic syndrome by integrative analysis of metabolomics and proteomics |
| url | https://doi.org/10.1371/journal.pone.0270593 |
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