Copy number loss of (src homology 2 domain containing)-transforming protein 2 (<it>SHC2</it>) gene: discordant loss in monozygotic twins and frequent loss in patients with multiple system atrophy

Copy number loss of (src homology 2 domain containing)-transforming protein 2 (<it>SHC2</it>) gene: discordant loss in monozygotic twins and frequent loss in patients with multiple system atrophy

<p>Abstract</p> <p>Background</p> <p>Multiple system atrophy (MSA) is a sporadic disease. Its pathogenesis may involve multiple genetic and nongenetic factors, but its etiology remains largely unknown. We hypothesized that the genome of a patient with MSA would demonstr...

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Bibliographic Details
Main Authors: Sasaki Hidenao, Emi Mitsuru, Iijima Hiroshi, Ito Noriko, Sato Hidenori, Yabe Ichiro, Kato Takeo, Utsumi Jun, Matsubara Kenichi
Format: Article
Language:English
Published: BMC 2011-06-01
Series:Molecular Brain
Subjects:
Multiple system atrophy
copy number variation
phenotypically discordant monozygotic twins
(Src homology 2 domain containing)-transforming protein 2
subtelomere
ataxia
parkinsonism
disease-susceptibility gene
Online Access:http://www.molecularbrain.com/content/4/1/24

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