Herbal medications and natural products for patients with covid-19 and diabetes mellitus: Potentials and challenges
Background: The presence of diabetes mellitus (DM) among COVID-19 patients is associated with increased hospitalization, morbidity, and mortality. Evidence has shown that hyperglycemia potentiates SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection and plays a central role in seve...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-08-01
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| Series: | Phytomedicine Plus |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S266703132200063X |
| _version_ | 1811307181059866624 |
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| author | Abdurrahman Pharmacy Yusuf Jian-ye Zhang Jing-quan Li Aliyu Muhammad Murtala Bello Abubakar |
| author_facet | Abdurrahman Pharmacy Yusuf Jian-ye Zhang Jing-quan Li Aliyu Muhammad Murtala Bello Abubakar |
| author_sort | Abdurrahman Pharmacy Yusuf |
| collection | DOAJ |
| description | Background: The presence of diabetes mellitus (DM) among COVID-19 patients is associated with increased hospitalization, morbidity, and mortality. Evidence has shown that hyperglycemia potentiates SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection and plays a central role in severe COVID-19 and diabetes comorbidity. In this review, we explore the therapeutic potentials of herbal medications and natural products in the management of COVID-19 and DM comorbidity and the challenges associated with the preexisting or concurrent use of these substances. Methods: Research papers that were published from January 2016 to December 2021 were retrieved from PubMed, ScienceDirect, and Google Scholar databases. Papers reporting clinical evidence of antidiabetic activities and any available evidence of the anti-COVID-19 potential of ten selected natural products were retrieved and analyzed for discussion in this review. Results: A total of 548 papers (73 clinical trials on the antidiabetic activities of the selected natural products and 475 research and review articles on their anti-COVID-19 potential) were retrieved from the literature search for further analysis. A total of 517 articles (reviews and less relevant research papers) were excluded. A cumulative sum of thirty-one (31) research papers (20 clinical trials and 10 others) met the criteria and have been discussed in this review. Conclusion: The findings of this review suggest that phenolic compounds are the most promising phytochemicals in the management of COVID-19 and DM comorbidity. Curcumin and propolis have shown substantial evidence against COVID-19 and DM in humans and are thus, considered the best potential therapeutic options. |
| first_indexed | 2024-04-13T08:59:53Z |
| format | Article |
| id | doaj.art-6154a32a8e8247c6904d1d9b0df04352 |
| institution | Directory Open Access Journal |
| issn | 2667-0313 |
| language | English |
| last_indexed | 2024-04-13T08:59:53Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Phytomedicine Plus |
| spelling | doaj.art-6154a32a8e8247c6904d1d9b0df043522022-12-22T02:53:10ZengElsevierPhytomedicine Plus2667-03132022-08-0123100280Herbal medications and natural products for patients with covid-19 and diabetes mellitus: Potentials and challengesAbdurrahman Pharmacy Yusuf0Jian-ye Zhang1Jing-quan Li2Aliyu Muhammad3Murtala Bello Abubakar4Department of Biochemistry, School of Life Sciences, Federal University of Technology, P.M.B 65, Minna, Niger State, NigeriaGuangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, P.R. ChinaThe first Affiliated Hospital, Hainan Medical University, Haikou, P.R. ChinaDepartment of Biochemistry, Faculty of Life Sciences, Ahmadu Bello University Zaria, 810107, Kaduna State, NigeriaCentre for Advanced Medical Research and Training, Usmanu Danfodiyo University, Sokoto, Nigeria; Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Usmanu Danfodiyo University, P.M.B. 2254, Sokoto, Nigeria; Corresponding author.Background: The presence of diabetes mellitus (DM) among COVID-19 patients is associated with increased hospitalization, morbidity, and mortality. Evidence has shown that hyperglycemia potentiates SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection and plays a central role in severe COVID-19 and diabetes comorbidity. In this review, we explore the therapeutic potentials of herbal medications and natural products in the management of COVID-19 and DM comorbidity and the challenges associated with the preexisting or concurrent use of these substances. Methods: Research papers that were published from January 2016 to December 2021 were retrieved from PubMed, ScienceDirect, and Google Scholar databases. Papers reporting clinical evidence of antidiabetic activities and any available evidence of the anti-COVID-19 potential of ten selected natural products were retrieved and analyzed for discussion in this review. Results: A total of 548 papers (73 clinical trials on the antidiabetic activities of the selected natural products and 475 research and review articles on their anti-COVID-19 potential) were retrieved from the literature search for further analysis. A total of 517 articles (reviews and less relevant research papers) were excluded. A cumulative sum of thirty-one (31) research papers (20 clinical trials and 10 others) met the criteria and have been discussed in this review. Conclusion: The findings of this review suggest that phenolic compounds are the most promising phytochemicals in the management of COVID-19 and DM comorbidity. Curcumin and propolis have shown substantial evidence against COVID-19 and DM in humans and are thus, considered the best potential therapeutic options.http://www.sciencedirect.com/science/article/pii/S266703132200063XACE2ComorbidityCOVID-19DiabetesHerbal medicationNatural products |
| spellingShingle | Abdurrahman Pharmacy Yusuf Jian-ye Zhang Jing-quan Li Aliyu Muhammad Murtala Bello Abubakar Herbal medications and natural products for patients with covid-19 and diabetes mellitus: Potentials and challenges Phytomedicine Plus ACE2 Comorbidity COVID-19 Diabetes Herbal medication Natural products |
| title | Herbal medications and natural products for patients with covid-19 and diabetes mellitus: Potentials and challenges |
| title_full | Herbal medications and natural products for patients with covid-19 and diabetes mellitus: Potentials and challenges |
| title_fullStr | Herbal medications and natural products for patients with covid-19 and diabetes mellitus: Potentials and challenges |
| title_full_unstemmed | Herbal medications and natural products for patients with covid-19 and diabetes mellitus: Potentials and challenges |
| title_short | Herbal medications and natural products for patients with covid-19 and diabetes mellitus: Potentials and challenges |
| title_sort | herbal medications and natural products for patients with covid 19 and diabetes mellitus potentials and challenges |
| topic | ACE2 Comorbidity COVID-19 Diabetes Herbal medication Natural products |
| url | http://www.sciencedirect.com/science/article/pii/S266703132200063X |
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