Clinical and genetic characteristics of acute myeloid leukemia with t(8;21) in children and results of therapy according to protocol AML-MM-2000
<p>A t(8;21) is the most frequent abnormality in AML in children. Patients with this genetic abnormality are traditionally expected favorable prognosis with a probability of cure up to 80 %. Known additional cytogenetic abnormalities in AML with t(8;21) not affecting prognosis. These include l...
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ABV-press
2014-07-01
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| Series: | Онкогематология |
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| Online Access: | http://oncohematology.abvpress.ru/index.php/ongm/article/view/100 |
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| author | I. I. Kalinina M. M. Shneyder N. P. Kirsanova D. D. Baydildina E. V. Suntsova O. V. Goronkova L. A. Khachatryan G. A. Novichkova M. A. Maschan R. I. Yutskevich E. V. Volochnik T. V. Savitskaya N. V. Minakovskaya I. V. Proleskovskaya I. V. Emelyanova O. V. Karas N. V. Migal Yu. E. Mareyko A. G. Drekov J. V. Rumyantseva E. V. Fleyshman T. V. Nasedkina O. V. Aleynikova A. A. Maschan |
| author_facet | I. I. Kalinina M. M. Shneyder N. P. Kirsanova D. D. Baydildina E. V. Suntsova O. V. Goronkova L. A. Khachatryan G. A. Novichkova M. A. Maschan R. I. Yutskevich E. V. Volochnik T. V. Savitskaya N. V. Minakovskaya I. V. Proleskovskaya I. V. Emelyanova O. V. Karas N. V. Migal Yu. E. Mareyko A. G. Drekov J. V. Rumyantseva E. V. Fleyshman T. V. Nasedkina O. V. Aleynikova A. A. Maschan |
| author_sort | I. I. Kalinina |
| collection | DOAJ |
| description | <p>A t(8;21) is the most frequent abnormality in AML in children. Patients with this genetic abnormality are traditionally expected favorable prognosis with a probability of cure up to 80 %. Known additional cytogenetic abnormalities in AML with t(8;21) not affecting prognosis. These include loss of one sex chromosome and del(9q-). Prognosis impact of additional abnormalities involving chromosomes 7 and 11 in patients with t(8;21) is unknown. The purpose of this study was to analyse of additional anomalies, that occur in patients with t(8;21), and their influence on prognosis. During the study period 173 children with AML have received AML-MM-2000 treatment protocol in Russia and Belarus. Of these, in 33 patients (11 girls and 22 boys, median age — 10.5 years) t(8;21) was detected by chromosome banding or molecular-genetic analysis. In group with t(8;21) CNS leukemia in 8 patients was detected, extramedullary lesion — in 8 patients. In 4 patients CNS leukemia combined with presence of extramedullary lesions. These factors did not influence on therapy outcome. Overall survival of AML patients with t(8;21) was 0,67 ± 0,08 compared to 0,44 ± 0,04 in patients with AML without this translocation (p = 0,04). Special subgroup consist of 5 patients with t(8;21) and identified chromosomal abnormalities affecting chromosome 7 and 11, which were a poor prognostic factor: event-free survival in this subgroup of patients (n = 5) was 0,0 ± 0,0, compared to 0,34 ± 0,16 in patients with t(8;21) without additional anomalies (n = 28) (p = 0,027).</p> |
| first_indexed | 2024-04-10T18:08:10Z |
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| institution | Directory Open Access Journal |
| issn | 1818-8346 |
| language | Russian |
| last_indexed | 2024-04-10T18:08:10Z |
| publishDate | 2014-07-01 |
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| series | Онкогематология |
| spelling | doaj.art-61550d5fd7a3461ea6fbd41aa62aeae62023-02-02T12:07:25ZrusABV-pressОнкогематология1818-83462014-07-01611119115Clinical and genetic characteristics of acute myeloid leukemia with t(8;21) in children and results of therapy according to protocol AML-MM-2000I. I. Kalinina0M. M. Shneyder1N. P. Kirsanova2D. D. Baydildina3E. V. Suntsova4O. V. Goronkova5L. A. Khachatryan6G. A. Novichkova7M. A. Maschan8R. I. Yutskevich9E. V. Volochnik10T. V. Savitskaya11N. V. Minakovskaya12I. V. Proleskovskaya13I. V. Emelyanova14O. V. Karas15N. V. Migal16Yu. E. Mareyko17A. G. Drekov18J. V. Rumyantseva19E. V. Fleyshman20T. V. Nasedkina21O. V. Aleynikova22A. A. Maschan23Federal Research Center of Pediatric Hematology, Oncology and ImmunologyFederal Research Center of Pediatric Hematology, Oncology and ImmunologyRepublic Center of Pediatric Oncology and HematologyFederal Research Center of Pediatric Hematology, Oncology and ImmunologyFederal Research Center of Pediatric Hematology, Oncology and ImmunologyFederal Research Center of Pediatric Hematology, Oncology and ImmunologyFederal Research Center of Pediatric Hematology, Oncology and ImmunologyFederal Research Center of Pediatric Hematology, Oncology and ImmunologyFederal Research Center of Pediatric Hematology, Oncology and ImmunologyRepublic Center of Pediatric Oncology and HematologyRepublic Center of Pediatric Oncology and HematologyRepublic Center of Pediatric Oncology and HematologyRepublic Center of Pediatric Oncology and HematologyRepublic Center of Pediatric Oncology and HematologyRepublic Center of Pediatric Oncology and HematologyRepublic Center of Pediatric Oncology and HematologyRepublic Center of Pediatric Oncology and HematologyRepublic Center of Pediatric Oncology and HematologyRepublic Center of Pediatric Oncology and HematologyFederal Research Center of Pediatric Hematology, Oncology and ImmunologyInstitute of Cancerogenesis, N.N. Blokhin Cancer Research Center, Russian Academy of Medical SciencesEngelhardt Institute of Molecular Biology, Russian Academy of SciencesRepublic Center of Pediatric Oncology and HematologyFederal Research Center of Pediatric Hematology, Oncology and Immunology<p>A t(8;21) is the most frequent abnormality in AML in children. Patients with this genetic abnormality are traditionally expected favorable prognosis with a probability of cure up to 80 %. Known additional cytogenetic abnormalities in AML with t(8;21) not affecting prognosis. These include loss of one sex chromosome and del(9q-). Prognosis impact of additional abnormalities involving chromosomes 7 and 11 in patients with t(8;21) is unknown. The purpose of this study was to analyse of additional anomalies, that occur in patients with t(8;21), and their influence on prognosis. During the study period 173 children with AML have received AML-MM-2000 treatment protocol in Russia and Belarus. Of these, in 33 patients (11 girls and 22 boys, median age — 10.5 years) t(8;21) was detected by chromosome banding or molecular-genetic analysis. In group with t(8;21) CNS leukemia in 8 patients was detected, extramedullary lesion — in 8 patients. In 4 patients CNS leukemia combined with presence of extramedullary lesions. These factors did not influence on therapy outcome. Overall survival of AML patients with t(8;21) was 0,67 ± 0,08 compared to 0,44 ± 0,04 in patients with AML without this translocation (p = 0,04). Special subgroup consist of 5 patients with t(8;21) and identified chromosomal abnormalities affecting chromosome 7 and 11, which were a poor prognostic factor: event-free survival in this subgroup of patients (n = 5) was 0,0 ± 0,0, compared to 0,34 ± 0,16 in patients with t(8;21) without additional anomalies (n = 28) (p = 0,027).</p>http://oncohematology.abvpress.ru/index.php/ongm/article/view/100childrenacute myeloid leukemiat(821)AML-MM-2000 protocol |
| spellingShingle | I. I. Kalinina M. M. Shneyder N. P. Kirsanova D. D. Baydildina E. V. Suntsova O. V. Goronkova L. A. Khachatryan G. A. Novichkova M. A. Maschan R. I. Yutskevich E. V. Volochnik T. V. Savitskaya N. V. Minakovskaya I. V. Proleskovskaya I. V. Emelyanova O. V. Karas N. V. Migal Yu. E. Mareyko A. G. Drekov J. V. Rumyantseva E. V. Fleyshman T. V. Nasedkina O. V. Aleynikova A. A. Maschan Clinical and genetic characteristics of acute myeloid leukemia with t(8;21) in children and results of therapy according to protocol AML-MM-2000 Онкогематология children acute myeloid leukemia t(8 21) AML-MM-2000 protocol |
| title | Clinical and genetic characteristics of acute myeloid leukemia with t(8;21) in children and results of therapy according to protocol AML-MM-2000 |
| title_full | Clinical and genetic characteristics of acute myeloid leukemia with t(8;21) in children and results of therapy according to protocol AML-MM-2000 |
| title_fullStr | Clinical and genetic characteristics of acute myeloid leukemia with t(8;21) in children and results of therapy according to protocol AML-MM-2000 |
| title_full_unstemmed | Clinical and genetic characteristics of acute myeloid leukemia with t(8;21) in children and results of therapy according to protocol AML-MM-2000 |
| title_short | Clinical and genetic characteristics of acute myeloid leukemia with t(8;21) in children and results of therapy according to protocol AML-MM-2000 |
| title_sort | clinical and genetic characteristics of acute myeloid leukemia with t 8 21 in children and results of therapy according to protocol aml mm 2000 |
| topic | children acute myeloid leukemia t(8 21) AML-MM-2000 protocol |
| url | http://oncohematology.abvpress.ru/index.php/ongm/article/view/100 |
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