Micellar Drug Delivery Systems Based on Natural Biopolymers
The broad diversity of structures and the presence of numerous functional groups available for chemical modifications represent an enormous advantage for the development of safe, non-toxic, and cost-effective micellar drug delivery systems (DDS) based on natural biopolymers, such as polysaccharides,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/13/3/477 |
| _version_ | 1797416208589389824 |
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| author | Leonard Ionut Atanase |
| author_facet | Leonard Ionut Atanase |
| author_sort | Leonard Ionut Atanase |
| collection | DOAJ |
| description | The broad diversity of structures and the presence of numerous functional groups available for chemical modifications represent an enormous advantage for the development of safe, non-toxic, and cost-effective micellar drug delivery systems (DDS) based on natural biopolymers, such as polysaccharides, proteins, and peptides. Different drug-loading methods are used for the preparation of these micellar systems, but it appeared that dialysis is generally recommended, as it avoids the formation of large micellar aggregates. Moreover, the preparation method has an important influence on micellar size, morphology, and drug loading efficiency. The small size allows the passive accumulation of these micellar systems via the permeability and retention effect. Natural biopolymer-based micellar DDS are high-value biomaterials characterized by good compatibility, biodegradability, long blood circulation time, non-toxicity, non-immunogenicity, and high drug loading, and they are biodegraded to non-toxic products that are easily assimilated by the human body. Even if some recent studies reported better antitumoral effects for the micellar DDS based on polysaccharides than for commercial formulations, their clinical use is not yet generalized. This review is focused on the studies from the last decade concerning the preparation as well as the colloidal and biological characterization of micellar DDS based on natural biopolymers. |
| first_indexed | 2024-03-09T06:00:09Z |
| format | Article |
| id | doaj.art-6157af6586be43e7b7c80c6a8f0ccf5e |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-09T06:00:09Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-6157af6586be43e7b7c80c6a8f0ccf5e2023-12-03T12:09:22ZengMDPI AGPolymers2073-43602021-02-0113347710.3390/polym13030477Micellar Drug Delivery Systems Based on Natural BiopolymersLeonard Ionut Atanase0Department of Biomaterials, Faculty of Medical Dentistry, “Apollonia” University of Iasi, Pacurari Street, No. 11, 700511 Iasi, RomaniaThe broad diversity of structures and the presence of numerous functional groups available for chemical modifications represent an enormous advantage for the development of safe, non-toxic, and cost-effective micellar drug delivery systems (DDS) based on natural biopolymers, such as polysaccharides, proteins, and peptides. Different drug-loading methods are used for the preparation of these micellar systems, but it appeared that dialysis is generally recommended, as it avoids the formation of large micellar aggregates. Moreover, the preparation method has an important influence on micellar size, morphology, and drug loading efficiency. The small size allows the passive accumulation of these micellar systems via the permeability and retention effect. Natural biopolymer-based micellar DDS are high-value biomaterials characterized by good compatibility, biodegradability, long blood circulation time, non-toxicity, non-immunogenicity, and high drug loading, and they are biodegraded to non-toxic products that are easily assimilated by the human body. Even if some recent studies reported better antitumoral effects for the micellar DDS based on polysaccharides than for commercial formulations, their clinical use is not yet generalized. This review is focused on the studies from the last decade concerning the preparation as well as the colloidal and biological characterization of micellar DDS based on natural biopolymers.https://www.mdpi.com/2073-4360/13/3/477micelleself-assemblypolysaccharidespeptidesproteinsdrug delivery systems |
| spellingShingle | Leonard Ionut Atanase Micellar Drug Delivery Systems Based on Natural Biopolymers Polymers micelle self-assembly polysaccharides peptides proteins drug delivery systems |
| title | Micellar Drug Delivery Systems Based on Natural Biopolymers |
| title_full | Micellar Drug Delivery Systems Based on Natural Biopolymers |
| title_fullStr | Micellar Drug Delivery Systems Based on Natural Biopolymers |
| title_full_unstemmed | Micellar Drug Delivery Systems Based on Natural Biopolymers |
| title_short | Micellar Drug Delivery Systems Based on Natural Biopolymers |
| title_sort | micellar drug delivery systems based on natural biopolymers |
| topic | micelle self-assembly polysaccharides peptides proteins drug delivery systems |
| url | https://www.mdpi.com/2073-4360/13/3/477 |
| work_keys_str_mv | AT leonardionutatanase micellardrugdeliverysystemsbasedonnaturalbiopolymers |