The pleiotropic roles of circular and long noncoding RNAs in cutaneous melanoma
Cutaneous melanoma (CM) is a very aggressive disease, often characterized by unresponsiveness to conventional therapies and high mortality rates worldwide. The identification of the activating BRAFV600 mutations in approximately 50% of CM patients has recently fueled the development of novel small‐m...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-02-01
|
| Series: | Molecular Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/1878-0261.13034 |
| _version_ | 1818322438592659456 |
|---|---|
| author | Barbara Montico Giorgio Giurato Giovanni Pecoraro Annamaria Salvati Alessia Covre Francesca Colizzi Agostino Steffan Alessandro Weisz Michele Maio Luca Sigalotti Elisabetta Fratta |
| author_facet | Barbara Montico Giorgio Giurato Giovanni Pecoraro Annamaria Salvati Alessia Covre Francesca Colizzi Agostino Steffan Alessandro Weisz Michele Maio Luca Sigalotti Elisabetta Fratta |
| author_sort | Barbara Montico |
| collection | DOAJ |
| description | Cutaneous melanoma (CM) is a very aggressive disease, often characterized by unresponsiveness to conventional therapies and high mortality rates worldwide. The identification of the activating BRAFV600 mutations in approximately 50% of CM patients has recently fueled the development of novel small‐molecule inhibitors that specifically target BRAFV600‐mutant CM. In addition, a major progress in CM treatment has been made by monoclonal antibodies that regulate the immune checkpoint inhibitors. However, although target‐based therapies and immunotherapeutic strategies have yielded promising results, CM treatment remains a major challenge. In the last decade, accumulating evidence points to the aberrant expression of different types of noncoding RNAs (ncRNAs) in CM. While studies on microRNAs have grown exponentially leading to significant insights on CM biology, the role of circular RNAs (circRNAs) and long noncoding RNAs (lncRNAs) in this tumor is less understood, and much remains to be discovered. Here, we summarize and critically review the available evidence on the molecular functions of circRNAs and lncRNAs in BRAFV600‐mutant CM and CM immunogenicity, providing recent updates on their functional role in targeted therapy and immunotherapy resistance. In addition, we also include an evaluation of several algorithms and databases for prediction and validation of circRNA and lncRNA functional interactions. |
| first_indexed | 2024-12-13T10:56:48Z |
| format | Article |
| id | doaj.art-6158288d892c4ad6a7f0325da3d7138b |
| institution | Directory Open Access Journal |
| issn | 1574-7891 1878-0261 |
| language | English |
| last_indexed | 2024-12-13T10:56:48Z |
| publishDate | 2022-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Molecular Oncology |
| spelling | doaj.art-6158288d892c4ad6a7f0325da3d7138b2022-12-21T23:49:27ZengWileyMolecular Oncology1574-78911878-02612022-02-0116356559310.1002/1878-0261.13034The pleiotropic roles of circular and long noncoding RNAs in cutaneous melanomaBarbara Montico0Giorgio Giurato1Giovanni Pecoraro2Annamaria Salvati3Alessia Covre4Francesca Colizzi5Agostino Steffan6Alessandro Weisz7Michele Maio8Luca Sigalotti9Elisabetta Fratta10Immunopathology and Cancer Biomarkers Centro di Riferimento Oncologico di Aviano (CRO) IRCCS Aviano ItalyLaboratory of Molecular Medicine and Genomics Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana' University of Salerno Baronissi ItalyLaboratory of Molecular Medicine and Genomics Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana' University of Salerno Baronissi ItalyLaboratory of Molecular Medicine and Genomics Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana' University of Salerno Baronissi ItalyCenter for Immuno‐Oncology University Hospital of Siena ItalyImmunopathology and Cancer Biomarkers Centro di Riferimento Oncologico di Aviano (CRO) IRCCS Aviano ItalyImmunopathology and Cancer Biomarkers Centro di Riferimento Oncologico di Aviano (CRO) IRCCS Aviano ItalyLaboratory of Molecular Medicine and Genomics Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana' University of Salerno Baronissi ItalyCenter for Immuno‐Oncology University Hospital of Siena ItalyOncogenetics and Functional Oncogenomics Unit Centro di Riferimento Oncologico di Aviano (CRO) IRCCS Aviano ItalyImmunopathology and Cancer Biomarkers Centro di Riferimento Oncologico di Aviano (CRO) IRCCS Aviano ItalyCutaneous melanoma (CM) is a very aggressive disease, often characterized by unresponsiveness to conventional therapies and high mortality rates worldwide. The identification of the activating BRAFV600 mutations in approximately 50% of CM patients has recently fueled the development of novel small‐molecule inhibitors that specifically target BRAFV600‐mutant CM. In addition, a major progress in CM treatment has been made by monoclonal antibodies that regulate the immune checkpoint inhibitors. However, although target‐based therapies and immunotherapeutic strategies have yielded promising results, CM treatment remains a major challenge. In the last decade, accumulating evidence points to the aberrant expression of different types of noncoding RNAs (ncRNAs) in CM. While studies on microRNAs have grown exponentially leading to significant insights on CM biology, the role of circular RNAs (circRNAs) and long noncoding RNAs (lncRNAs) in this tumor is less understood, and much remains to be discovered. Here, we summarize and critically review the available evidence on the molecular functions of circRNAs and lncRNAs in BRAFV600‐mutant CM and CM immunogenicity, providing recent updates on their functional role in targeted therapy and immunotherapy resistance. In addition, we also include an evaluation of several algorithms and databases for prediction and validation of circRNA and lncRNA functional interactions.https://doi.org/10.1002/1878-0261.13034circular RNAscutaneous melanomaimmunotherapylong noncoding RNAstargeted therapy |
| spellingShingle | Barbara Montico Giorgio Giurato Giovanni Pecoraro Annamaria Salvati Alessia Covre Francesca Colizzi Agostino Steffan Alessandro Weisz Michele Maio Luca Sigalotti Elisabetta Fratta The pleiotropic roles of circular and long noncoding RNAs in cutaneous melanoma Molecular Oncology circular RNAs cutaneous melanoma immunotherapy long noncoding RNAs targeted therapy |
| title | The pleiotropic roles of circular and long noncoding RNAs in cutaneous melanoma |
| title_full | The pleiotropic roles of circular and long noncoding RNAs in cutaneous melanoma |
| title_fullStr | The pleiotropic roles of circular and long noncoding RNAs in cutaneous melanoma |
| title_full_unstemmed | The pleiotropic roles of circular and long noncoding RNAs in cutaneous melanoma |
| title_short | The pleiotropic roles of circular and long noncoding RNAs in cutaneous melanoma |
| title_sort | pleiotropic roles of circular and long noncoding rnas in cutaneous melanoma |
| topic | circular RNAs cutaneous melanoma immunotherapy long noncoding RNAs targeted therapy |
| url | https://doi.org/10.1002/1878-0261.13034 |
| work_keys_str_mv | AT barbaramontico thepleiotropicrolesofcircularandlongnoncodingrnasincutaneousmelanoma AT giorgiogiurato thepleiotropicrolesofcircularandlongnoncodingrnasincutaneousmelanoma AT giovannipecoraro thepleiotropicrolesofcircularandlongnoncodingrnasincutaneousmelanoma AT annamariasalvati thepleiotropicrolesofcircularandlongnoncodingrnasincutaneousmelanoma AT alessiacovre thepleiotropicrolesofcircularandlongnoncodingrnasincutaneousmelanoma AT francescacolizzi thepleiotropicrolesofcircularandlongnoncodingrnasincutaneousmelanoma AT agostinosteffan thepleiotropicrolesofcircularandlongnoncodingrnasincutaneousmelanoma AT alessandroweisz thepleiotropicrolesofcircularandlongnoncodingrnasincutaneousmelanoma AT michelemaio thepleiotropicrolesofcircularandlongnoncodingrnasincutaneousmelanoma AT lucasigalotti thepleiotropicrolesofcircularandlongnoncodingrnasincutaneousmelanoma AT elisabettafratta thepleiotropicrolesofcircularandlongnoncodingrnasincutaneousmelanoma AT barbaramontico pleiotropicrolesofcircularandlongnoncodingrnasincutaneousmelanoma AT giorgiogiurato pleiotropicrolesofcircularandlongnoncodingrnasincutaneousmelanoma AT giovannipecoraro pleiotropicrolesofcircularandlongnoncodingrnasincutaneousmelanoma AT annamariasalvati pleiotropicrolesofcircularandlongnoncodingrnasincutaneousmelanoma AT alessiacovre pleiotropicrolesofcircularandlongnoncodingrnasincutaneousmelanoma AT francescacolizzi pleiotropicrolesofcircularandlongnoncodingrnasincutaneousmelanoma AT agostinosteffan pleiotropicrolesofcircularandlongnoncodingrnasincutaneousmelanoma AT alessandroweisz pleiotropicrolesofcircularandlongnoncodingrnasincutaneousmelanoma AT michelemaio pleiotropicrolesofcircularandlongnoncodingrnasincutaneousmelanoma AT lucasigalotti pleiotropicrolesofcircularandlongnoncodingrnasincutaneousmelanoma AT elisabettafratta pleiotropicrolesofcircularandlongnoncodingrnasincutaneousmelanoma |