Anti-Diabetic Activity of Polysaccharides from <i>Auricularia cornea</i> var. Li.
<i>Auricularia cornea</i> var. Li. polysaccharide (ACP) has many important biological activities and has potential application value in food engineering, pharmaceutical science, and health care. The results were as follows: the extraction rate of ACP was 28.18% ± 1.41% and the purity of...
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MDPI AG
2022-05-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/11/10/1464 |
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| author | Yuan Fu Liwen Wang Guochuan Jiang Lili Ren Liyan Wang Xuejun Liu |
| author_facet | Yuan Fu Liwen Wang Guochuan Jiang Lili Ren Liyan Wang Xuejun Liu |
| author_sort | Yuan Fu |
| collection | DOAJ |
| description | <i>Auricularia cornea</i> var. Li. polysaccharide (ACP) has many important biological activities and has potential application value in food engineering, pharmaceutical science, and health care. The results were as follows: the extraction rate of ACP was 28.18% ± 1.41% and the purity of ACP was 86.92% ± 2.80%. ACP contains mannitol 32.41%, glucuronic acid 6.96%, rhamnose 0.32%, glucose 42.35%, galactose 0.77%, xylose 16.83%, and fucose 0.36%, without galacturonic acid and arabinose. In addition, the results of an animal test of diabetes mellitus II (DM II) with ACP showed that the total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and fasting blood glucose and water in the serum of mice with ACP were significantly lower than those in the model group; the serum SOD, hepatic glycogen, and insulin of mice added with ACP were significantly higher than those in the model group. More importantly, ACP had no significant adverse effects on organ index and liver and kidney tissue morphology in mice. These results suggest that ACP can be used as a potential functional food component for the prevention or treatment of diabetes. |
| first_indexed | 2024-03-10T03:54:07Z |
| format | Article |
| id | doaj.art-615881d947064437adb015be1bfba48d |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-10T03:54:07Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-615881d947064437adb015be1bfba48d2023-11-23T10:59:34ZengMDPI AGFoods2304-81582022-05-011110146410.3390/foods11101464Anti-Diabetic Activity of Polysaccharides from <i>Auricularia cornea</i> var. Li.Yuan Fu0Liwen Wang1Guochuan Jiang2Lili Ren3Liyan Wang4Xuejun Liu5College of Food Science and Engineering, Jilin Agricultural University, 2888 Xincheng Street, Changchun 130118, ChinaChina South Korea (Changchun) International Cooperation Demonstration Zone Management Committee, Changchun 130042, ChinaCollege of Food Science and Engineering, Jilin Agricultural University, 2888 Xincheng Street, Changchun 130118, ChinaKey Laboratory of Bionic Engineering (Ministry of Education), College of Biological and Agricultural Engineering, Jilin University, 5988 Renmin Street, Changchun 130022, ChinaCollege of Food Science and Engineering, Jilin Agricultural University, 2888 Xincheng Street, Changchun 130118, ChinaCollege of Food Science and Engineering, Jilin Agricultural University, 2888 Xincheng Street, Changchun 130118, China<i>Auricularia cornea</i> var. Li. polysaccharide (ACP) has many important biological activities and has potential application value in food engineering, pharmaceutical science, and health care. The results were as follows: the extraction rate of ACP was 28.18% ± 1.41% and the purity of ACP was 86.92% ± 2.80%. ACP contains mannitol 32.41%, glucuronic acid 6.96%, rhamnose 0.32%, glucose 42.35%, galactose 0.77%, xylose 16.83%, and fucose 0.36%, without galacturonic acid and arabinose. In addition, the results of an animal test of diabetes mellitus II (DM II) with ACP showed that the total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and fasting blood glucose and water in the serum of mice with ACP were significantly lower than those in the model group; the serum SOD, hepatic glycogen, and insulin of mice added with ACP were significantly higher than those in the model group. More importantly, ACP had no significant adverse effects on organ index and liver and kidney tissue morphology in mice. These results suggest that ACP can be used as a potential functional food component for the prevention or treatment of diabetes.https://www.mdpi.com/2304-8158/11/10/1464<i>Auricularia cornea</i> var. Li.polysaccharidesdiabetes mellitus II |
| spellingShingle | Yuan Fu Liwen Wang Guochuan Jiang Lili Ren Liyan Wang Xuejun Liu Anti-Diabetic Activity of Polysaccharides from <i>Auricularia cornea</i> var. Li. Foods <i>Auricularia cornea</i> var. Li. polysaccharides diabetes mellitus II |
| title | Anti-Diabetic Activity of Polysaccharides from <i>Auricularia cornea</i> var. Li. |
| title_full | Anti-Diabetic Activity of Polysaccharides from <i>Auricularia cornea</i> var. Li. |
| title_fullStr | Anti-Diabetic Activity of Polysaccharides from <i>Auricularia cornea</i> var. Li. |
| title_full_unstemmed | Anti-Diabetic Activity of Polysaccharides from <i>Auricularia cornea</i> var. Li. |
| title_short | Anti-Diabetic Activity of Polysaccharides from <i>Auricularia cornea</i> var. Li. |
| title_sort | anti diabetic activity of polysaccharides from i auricularia cornea i var li |
| topic | <i>Auricularia cornea</i> var. Li. polysaccharides diabetes mellitus II |
| url | https://www.mdpi.com/2304-8158/11/10/1464 |
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