Continuous acceleration of neural activity of the GnRH pulse generator during chronic peripheral infusion of neurokinin 3 receptor agonist in goats
Secretion of pulsatile gonadotropin-releasing hormone (GnRH) is essential for reproduction. Kisspeptin neurons in the arcuate nucleus (ARC), which coexpress neurokinin B (NKB) and its receptor (NK3R), are believed to be components of the GnRH pulse generator that regulates pulsatile GnRH secretion....
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| Format: | Article |
| Language: | English |
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The Society for Reproduction and Development
2023-06-01
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| Series: | The Journal of Reproduction and Development |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jrd/69/4/69_2023-025/_pdf/-char/en |
| _version_ | 1797633936024666112 |
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| author | Takashi YAMAMURA Hiroaki OKAMURA Yoshihiro WAKABAYASHI |
| author_facet | Takashi YAMAMURA Hiroaki OKAMURA Yoshihiro WAKABAYASHI |
| author_sort | Takashi YAMAMURA |
| collection | DOAJ |
| description | Secretion of pulsatile gonadotropin-releasing hormone (GnRH) is essential for reproduction. Kisspeptin neurons in the arcuate nucleus (ARC), which coexpress neurokinin B (NKB) and its receptor (NK3R), are believed to be components of the GnRH pulse generator that regulates pulsatile GnRH secretion. We examined the effects of peripheral infusion of senktide, an NK3R selective agonist, on GnRH pulse generator activity by monitoring multiple unit activity (MUA) in the goat ARC. Previous studies have shown that characteristic increases in MUA (MUA volleys) reflect GnRH pulse generator activity. Senktide was infused intravenously or intravaginally for 2 h while recording MUA. Both infusions significantly increased the MUA volley frequency compared with the control. These results demonstrate that peripherally administered senktide acts centrally to sustainably accelerate the neural activity of the GnRH pulse generator throughout the infusion period. This suggests the possibility of practical applications of NK3R agonists for improving reproductive activity in farm animals. |
| first_indexed | 2024-03-11T12:01:40Z |
| format | Article |
| id | doaj.art-61597db9a9434bb09ab57c130e7fc651 |
| institution | Directory Open Access Journal |
| issn | 0916-8818 1348-4400 |
| language | English |
| last_indexed | 2024-03-11T12:01:40Z |
| publishDate | 2023-06-01 |
| publisher | The Society for Reproduction and Development |
| record_format | Article |
| series | The Journal of Reproduction and Development |
| spelling | doaj.art-61597db9a9434bb09ab57c130e7fc6512023-11-08T04:40:57ZengThe Society for Reproduction and DevelopmentThe Journal of Reproduction and Development0916-88181348-44002023-06-0169421822210.1262/jrd.2023-025jrdContinuous acceleration of neural activity of the GnRH pulse generator during chronic peripheral infusion of neurokinin 3 receptor agonist in goatsTakashi YAMAMURA0Hiroaki OKAMURA1Yoshihiro WAKABAYASHI2Livestock Reproduction Group, Division of Advanced Feeding Technology Research, Institute of Livestock and Grassland Science, National Agriculture and Food Research Organization (NARO), Ibaraki 305-0901, JapanLivestock Reproduction Group, Division of Advanced Feeding Technology Research, Institute of Livestock and Grassland Science, National Agriculture and Food Research Organization (NARO), Ibaraki 305-0901, JapanLivestock Reproduction Group, Division of Advanced Feeding Technology Research, Institute of Livestock and Grassland Science, National Agriculture and Food Research Organization (NARO), Ibaraki 305-0901, JapanSecretion of pulsatile gonadotropin-releasing hormone (GnRH) is essential for reproduction. Kisspeptin neurons in the arcuate nucleus (ARC), which coexpress neurokinin B (NKB) and its receptor (NK3R), are believed to be components of the GnRH pulse generator that regulates pulsatile GnRH secretion. We examined the effects of peripheral infusion of senktide, an NK3R selective agonist, on GnRH pulse generator activity by monitoring multiple unit activity (MUA) in the goat ARC. Previous studies have shown that characteristic increases in MUA (MUA volleys) reflect GnRH pulse generator activity. Senktide was infused intravenously or intravaginally for 2 h while recording MUA. Both infusions significantly increased the MUA volley frequency compared with the control. These results demonstrate that peripherally administered senktide acts centrally to sustainably accelerate the neural activity of the GnRH pulse generator throughout the infusion period. This suggests the possibility of practical applications of NK3R agonists for improving reproductive activity in farm animals.https://www.jstage.jst.go.jp/article/jrd/69/4/69_2023-025/_pdf/-char/endrug deliverygnrh pulse generatorintravaginal administrationkisspeptinneurokinin b |
| spellingShingle | Takashi YAMAMURA Hiroaki OKAMURA Yoshihiro WAKABAYASHI Continuous acceleration of neural activity of the GnRH pulse generator during chronic peripheral infusion of neurokinin 3 receptor agonist in goats The Journal of Reproduction and Development drug delivery gnrh pulse generator intravaginal administration kisspeptin neurokinin b |
| title | Continuous acceleration of neural activity of the GnRH pulse generator during chronic peripheral infusion of neurokinin 3 receptor agonist in goats |
| title_full | Continuous acceleration of neural activity of the GnRH pulse generator during chronic peripheral infusion of neurokinin 3 receptor agonist in goats |
| title_fullStr | Continuous acceleration of neural activity of the GnRH pulse generator during chronic peripheral infusion of neurokinin 3 receptor agonist in goats |
| title_full_unstemmed | Continuous acceleration of neural activity of the GnRH pulse generator during chronic peripheral infusion of neurokinin 3 receptor agonist in goats |
| title_short | Continuous acceleration of neural activity of the GnRH pulse generator during chronic peripheral infusion of neurokinin 3 receptor agonist in goats |
| title_sort | continuous acceleration of neural activity of the gnrh pulse generator during chronic peripheral infusion of neurokinin 3 receptor agonist in goats |
| topic | drug delivery gnrh pulse generator intravaginal administration kisspeptin neurokinin b |
| url | https://www.jstage.jst.go.jp/article/jrd/69/4/69_2023-025/_pdf/-char/en |
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