Mitochondrial mutations in adenoid cystic carcinoma of the salivary glands.
The MitoChip v2.0 resequencing array is an array-based technique allowing for accurate and complete sequencing of the mitochondrial genome. No studies have investigated mitochondrial mutation in salivary gland adenoid cystic carcinomas.The entire mitochondrial genome of 22 salivary gland adenoid cys...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2009-12-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC2795173?pdf=render |
| _version_ | 1819074380674629632 |
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| author | Suhail K Mithani Chunbo Shao Marietta Tan Ian M Smith Joseph A Califano Adel K El-Naggar Patrick K Ha |
| author_facet | Suhail K Mithani Chunbo Shao Marietta Tan Ian M Smith Joseph A Califano Adel K El-Naggar Patrick K Ha |
| author_sort | Suhail K Mithani |
| collection | DOAJ |
| description | The MitoChip v2.0 resequencing array is an array-based technique allowing for accurate and complete sequencing of the mitochondrial genome. No studies have investigated mitochondrial mutation in salivary gland adenoid cystic carcinomas.The entire mitochondrial genome of 22 salivary gland adenoid cystic carcinomas (ACC) of salivary glands and matched leukocyte DNA was sequenced to determine the frequency and distribution of mitochondrial mutations in ACC tumors.Seventeen of 22 ACCs (77%) carried mitochondrial mutations, ranging in number from 1 to 37 mutations. A disproportionate number of mutations occurred in the D-loop. Twelve of 17 tumors (70.6%) carried mutations resulting in amino acid changes of translated proteins. Nine of 17 tumors (52.9%) with a mutation carried an amino acid changing mutation in the nicotinamide adenine dinucleotide dehydrogenase (NADH) complex.Mitochondrial mutation is frequent in salivary ACCs. The high incidence of amino acid changing mutations implicates alterations in aerobic respiration in ACC carcinogenesis. D-loop mutations are of unclear significance, but may be associated with alterations in transcription or replication. |
| first_indexed | 2024-12-21T18:08:36Z |
| format | Article |
| id | doaj.art-615cb7a7dd1343cea9176ab347d26826 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T18:08:36Z |
| publishDate | 2009-12-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-615cb7a7dd1343cea9176ab347d268262022-12-21T18:54:52ZengPublic Library of Science (PLoS)PLoS ONE1932-62032009-12-01412e849310.1371/journal.pone.0008493Mitochondrial mutations in adenoid cystic carcinoma of the salivary glands.Suhail K MithaniChunbo ShaoMarietta TanIan M SmithJoseph A CalifanoAdel K El-NaggarPatrick K HaThe MitoChip v2.0 resequencing array is an array-based technique allowing for accurate and complete sequencing of the mitochondrial genome. No studies have investigated mitochondrial mutation in salivary gland adenoid cystic carcinomas.The entire mitochondrial genome of 22 salivary gland adenoid cystic carcinomas (ACC) of salivary glands and matched leukocyte DNA was sequenced to determine the frequency and distribution of mitochondrial mutations in ACC tumors.Seventeen of 22 ACCs (77%) carried mitochondrial mutations, ranging in number from 1 to 37 mutations. A disproportionate number of mutations occurred in the D-loop. Twelve of 17 tumors (70.6%) carried mutations resulting in amino acid changes of translated proteins. Nine of 17 tumors (52.9%) with a mutation carried an amino acid changing mutation in the nicotinamide adenine dinucleotide dehydrogenase (NADH) complex.Mitochondrial mutation is frequent in salivary ACCs. The high incidence of amino acid changing mutations implicates alterations in aerobic respiration in ACC carcinogenesis. D-loop mutations are of unclear significance, but may be associated with alterations in transcription or replication.http://europepmc.org/articles/PMC2795173?pdf=render |
| spellingShingle | Suhail K Mithani Chunbo Shao Marietta Tan Ian M Smith Joseph A Califano Adel K El-Naggar Patrick K Ha Mitochondrial mutations in adenoid cystic carcinoma of the salivary glands. PLoS ONE |
| title | Mitochondrial mutations in adenoid cystic carcinoma of the salivary glands. |
| title_full | Mitochondrial mutations in adenoid cystic carcinoma of the salivary glands. |
| title_fullStr | Mitochondrial mutations in adenoid cystic carcinoma of the salivary glands. |
| title_full_unstemmed | Mitochondrial mutations in adenoid cystic carcinoma of the salivary glands. |
| title_short | Mitochondrial mutations in adenoid cystic carcinoma of the salivary glands. |
| title_sort | mitochondrial mutations in adenoid cystic carcinoma of the salivary glands |
| url | http://europepmc.org/articles/PMC2795173?pdf=render |
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