Construction of Interferon-Gamma-Related Gene Signature to Characterize the Immune-Inflamed Phenotype of Glioblastoma and Predict Prognosis, Efficacy of Immunotherapy and Radiotherapy

Construction of Interferon-Gamma-Related Gene Signature to Characterize the Immune-Inflamed Phenotype of Glioblastoma and Predict Prognosis, Efficacy of Immunotherapy and Radiotherapy

Interferon-gamma (IFNG) has profound impacts on tumor-immune interaction and is of great clinical significance for multiple cancers. Exploring the role of IFNG in glioblastoma (GBM) may optimize the current treatment paradigm of this disease. Here, multi-dimensional data of 429 GBM samples were coll...

Full description

Bibliographic Details
Main Authors:	Hang Ji, Yixu Ba, Shuai Ma, Kuiyuan Hou, Shan Mi, Xin Gao, Jiaqi Jin, Qin Gong, Ting Liu, Fang Wang, Zhihui Liu, Shupeng Li, Jianyang Du, Shaoshan Hu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-09-01
Series:	Frontiers in Immunology
Subjects:	glioblastoma interferon-gamma tumor immune microenvironment IFNG-related gene signature anti-tumor immune response immune checkpoint blockade therapy
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.729359/full

Similar Items

Recognition of Tumor-Associated Antigens and Immune Subtypes in Glioma for mRNA Vaccine Development
by: Shuai Ma, et al.
Published: (2021-09-01)

Identification of Prognostic Model and Biomarkers for Cancer Stem Cell Characteristics in Glioblastoma by Network Analysis of Multi-Omics Data and Stemness Indices
by: Jianyang Du, et al.
Published: (2020-10-01)

Multiomics Data Analysis and Identification of Immune-Related Prognostic Signatures With Potential Implications in Prognosis and Immune Checkpoint Blockade Therapy of Glioblastoma
by: Shuai Ma, et al.
Published: (2022-05-01)

Extended Application of Genomic Selection to Screen Multi-Omics Data for the Development of Novel Pyroptosis-Immune Signatures and Predicting Immunotherapy of Glioma
by: Shuai Ma, et al.
Published: (2022-05-01)

Integrated analysis of genome-wide DNA methylation and cancer-associated fibroblasts identified prognostic biomarkers and immune checkpoint blockade in lower grade gliomas
by: Jiawei Dong, et al.
Published: (2023-01-01)

Identification of EMT-Related Genes and Prognostic Signature With Significant Implications on Biological Properties and Oncology Treatment of Lower Grade Gliomas
by: Jiasheng Wu, et al.
Published: (2022-05-01)

Novel macrophage-related gene prognostic index for glioblastoma associated with M2 macrophages and T cell dysfunction
by: Hang Ji, et al.
Published: (2022-09-01)

Identification of Implications of Angiogenesis and m6A Modification on Immunosuppression and Therapeutic Sensitivity in Low-Grade Glioma by Network Computational Analysis of Subtypes and Signatures
by: Bo Li, et al.
Published: (2022-04-01)

Expression of intra-tumoral necrosis-associated cytokine pattern correlated with prognosis and immune status in glioma
by: Hongtao Zhao, et al.
Published: (2023-07-01)

Characterization of the Ferroptosis-Related Genes for Prognosis and Immune Infiltration in Low-Grade Glioma
by: Xiuwei Yan, et al.
Published: (2022-04-01)

Improvement of IFNg ELISPOT Performance Following Overnight Resting of Frozen PBMC Samples Confirmed Through Rigorous Statistical Analysis
by: Radleigh Santos, et al.
Published: (2014-12-01)

Prognostic value of CD8 + PD-1+ immune infiltrates and PDCD1 gene expression in triple negative breast cancer
by: Joe Yeong, et al.
Published: (2019-02-01)

Ferroptosis-Related Gene Contributes to Immunity, Stemness and Predicts Prognosis in Glioblastoma Multiforme
by: Jiawei Dong, et al.
Published: (2022-03-01)

Assessment of expression of interferon γ (IFN-G) gene and its antisense (IFNG-AS1) in breast cancer
by: Hajar Yaghoobi, et al.
Published: (2018-10-01)

Machine learning-based screening of an epithelial-mesenchymal transition-related long non-coding RNA signature reveals lower-grade glioma prognosis and the tumor microenvironment and predicts antitumor therapy response
by: Nan Wang, et al.
Published: (2022-08-01)

The relationship between autophagy and the immune system and its applications for tumor immunotherapy
by: Guan-Min Jiang, et al.
Published: (2019-01-01)

Tumor immune microenvironment (TIME) to enhance antitumor immunity
by: Sajin Rajbhandary, et al.
Published: (2023-05-01)

The role of the tumor microbe microenvironment in the tumor immune microenvironment: bystander, activator, or inhibitor?
by: Jiayao Ma, et al.
Published: (2021-10-01)

Molecular Mechanism of Tumor Cell Immune Escape Mediated by CD24/Siglec-10
by: Shan-Shan Yin, et al.
Published: (2020-07-01)

Interferon-Induced Transmembrane Protein 3 Shapes an Inflamed Tumor Microenvironment and Identifies Immuno-Hot Tumors
by: Yun Cai, et al.
Published: (2021-08-01)

Multidimensional modulation of systemic immune by neurosurgical tumor resection in patients with brain tumors
by: Jia‐Wei Wang, et al.
Published: (2022-10-01)

Stromal protein CCN family contributes to the poor prognosis in lower-grade gioma by modulating immunity, matrix, stemness, and metabolism
by: Zhihui Liu, et al.
Published: (2022-12-01)

CAPN8 involves with exhausted, inflamed, and desert immune microenvironment to influence the metastasis of thyroid cancer
by: Xiang Zhong, et al.
Published: (2022-10-01)

Integrated genomic, transcriptomic, and epigenetic analyses identify a leukotriene synthesis-related M2 macrophage gene signature that predicts prognosis and treatment vulnerability in gliomas
by: Hang Ji, et al.
Published: (2022-09-01)

Spatial architecture of the immune microenvironment orchestrates tumor immunity and therapeutic response
by: Tong Fu, et al.
Published: (2021-06-01)

The emerging roles of exosome-derived noncoding RNAs in the tumor immune microenvironment and their future applications
by: Fang Wei, et al.
Published: (2022-12-01)

The Role of Tumor Metabolic Reprogramming in Tumor Immunity
by: Xianhong Zhang, et al.
Published: (2023-12-01)

Review to Understand the Crosstalk between Immunotherapy and Tumor Metabolism
by: Pratibha Pandey, et al.
Published: (2023-01-01)

Relationship Between SerpinB9 and Tumors and Research Progress of SerpinB9 in Skin Tumors
by: ZHANG Shan, et al.
Published: (2022-09-01)

Multi-dimensional omics characterization in glioblastoma identifies the purity-associated pattern and prognostic gene signatures
by: Yi Xiong, et al.
Published: (2020-01-01)

Pyroptosis, metabolism, and tumor immune microenvironment
by: Tiantian Du, et al.
Published: (2021-08-01)

Ferroptosis, autophagy, tumor and immunity
by: Yuyan Xie, et al.
Published: (2023-09-01)

A novel cuproptosis-related subtypes and gene signature associates with immunophenotype and predicts prognosis accurately in neuroblastoma
by: Xiao-Mao Tian, et al.
Published: (2022-09-01)

Effect of Lactate on Immune Cells in Tumor Microenvironment and Progress of Related Target Therapy
by: JIN Mengru, et al.
Published: (2023-06-01)

Lactate in the tumor microenvironment: A rising star for targeted tumor therapy
by: Zhangzuo Li, et al.
Published: (2023-02-01)

A risk signature based on necroptotic-process-related genes predicts prognosis and immune therapy response in kidney cell carcinoma
by: Jingxian Li, et al.
Published: (2022-09-01)

The roles of exosomal immune checkpoint proteins in tumors
by: Cheng Xing, et al.
Published: (2021-11-01)

Identification of Tumor Antigens and Design of mRNA Vaccine for Colorectal Cancer Based on the Immune Subtype
by: Cong Liu, et al.
Published: (2022-01-01)

Mechanisms of Neutrophil Extracellular Trap Formation and Regulation in Cancers
by: Zhiyuan Zhang, et al.
Published: (2023-06-01)

Progress on the pathological roles of immune checkpoint CD276 protein in tumorigenesis and development
by: CHEN Zhongjie, HUANG Jiaru, HU Qing, ZHAO Zhenqin, CHEN Qiaoqiao, SUN Junyuan, JIA Jing
Published: (2023-07-01)