The effects of omega-3 fatty acids supplementation on hemoglobin, hematocrit, and platelet levels of patients with ESRD condition undergoing dialysis
Background: Concomitant inflammation may boost the cardiovascular complications in end-stage renal disease (ESRD) patients undergoing hemodialysis (HD). Omega-3 fatty acids may have certain health benefits in HD patients. The aim of this study was to investigate the effects of omega-3 fatty acids su...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | Journal of Translational Autoimmunity |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589909024000030 |
| _version_ | 1827221837446119424 |
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| author | Zahra Mahmoudi Zahra Roumi Seyed Ali Askarpour Zahra Mousavi Hanieh Shafaei Neda Valisoltani Mahsa Shapouri Seyed Reza Mirshafaei Pouya Mirzaee Khadijeh Abbasi Mobarakeh Elahe Taghavi Sufiani Zahra Mohammadi Nowdehi Zeynab Motiei Masoud Khosravi Saeid Doaei Maryam Gholamalizadeh |
| author_facet | Zahra Mahmoudi Zahra Roumi Seyed Ali Askarpour Zahra Mousavi Hanieh Shafaei Neda Valisoltani Mahsa Shapouri Seyed Reza Mirshafaei Pouya Mirzaee Khadijeh Abbasi Mobarakeh Elahe Taghavi Sufiani Zahra Mohammadi Nowdehi Zeynab Motiei Masoud Khosravi Saeid Doaei Maryam Gholamalizadeh |
| author_sort | Zahra Mahmoudi |
| collection | DOAJ |
| description | Background: Concomitant inflammation may boost the cardiovascular complications in end-stage renal disease (ESRD) patients undergoing hemodialysis (HD). Omega-3 fatty acids may have certain health benefits in HD patients. The aim of this study was to investigate the effects of omega-3 fatty acids supplementation on hematocrit (HCT), hemoglobin (HB) level and platelet (PLT) counts of HD patients. Methods: A randomized controlled trial was conducted on HD patients at a private dialysis center in Rasht, Iran. Three omega-3 fatty acid supplement capsules (3 g/d) were administered daily for two months to patients in the intervention group (n = 55). The control group (n = 60) were given three placebo capsules containing medium chain triglyceride (MCT) oil, similar to the supplemental dose of the intervention group at the same period. Three parameters of HCT, HB and PLT were measured at baseline and after the intervention. Results: The PLT count decreased in the intervention group compared to the control group (173.38 ± 74.76 vs. 227.68 ± 86.58 103/mm3, F = 4.83, P = 0.03). No significant change was found on the levels of HCT and HB parameters between the two groups after the intervention. Conclusion: Omega-3 supplementation in HD patients may decrease the risk of forming blood clots in the blood vessels. Further studies are warranted. |
| first_indexed | 2024-03-07T15:46:25Z |
| format | Article |
| id | doaj.art-615e15dfd2394064938473555488202f |
| institution | Directory Open Access Journal |
| issn | 2589-9090 |
| language | English |
| last_indexed | 2025-03-21T16:28:56Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Translational Autoimmunity |
| spelling | doaj.art-615e15dfd2394064938473555488202f2024-06-17T05:56:19ZengElsevierJournal of Translational Autoimmunity2589-90902024-06-018100233The effects of omega-3 fatty acids supplementation on hemoglobin, hematocrit, and platelet levels of patients with ESRD condition undergoing dialysisZahra Mahmoudi0Zahra Roumi1Seyed Ali Askarpour2Zahra Mousavi3Hanieh Shafaei4Neda Valisoltani5Mahsa Shapouri6Seyed Reza Mirshafaei7Pouya Mirzaee8Khadijeh Abbasi Mobarakeh9Elahe Taghavi Sufiani10Zahra Mohammadi Nowdehi11Zeynab Motiei12Masoud Khosravi13Saeid Doaei14Maryam Gholamalizadeh15Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, IranDepartment of Nutrition, Electronic Health and Statistics Surveillance Research Center, Science and Research Branch. Islamic Azad University, Tehran, IranDivision of Food Safety and Hygiene, Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, IranSchool of Nursing and Midwifery Shahed University, Tehran, IranDepartment of Nursing, School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, IranDepartment of Clinical Nutrition, School of Nutrition Science and Dietetics, Tehran University of Medical Sciences, Tehran, IranShahid Beheshti University of Medical Sciences, Tehran, IranDepartment of applied mathematics, Roudsar and Amlash branch, Islamic Azad University, Roudsar, IranDepartment of Medicine, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, IranDepartment of Community Nutrition, Nutrition and Food Security Research Center, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Nursing, School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, IranDepartment of Nursing, School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, IranDepartment of Nursing, School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, IranUrology Research Center, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran; Corresponding author. Faculty of Medicine, Guilan University of Medical Sciences, Guilan, Iran.Department of Community Nutrition, School of Nutrition and Food Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Corresponding author.Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranBackground: Concomitant inflammation may boost the cardiovascular complications in end-stage renal disease (ESRD) patients undergoing hemodialysis (HD). Omega-3 fatty acids may have certain health benefits in HD patients. The aim of this study was to investigate the effects of omega-3 fatty acids supplementation on hematocrit (HCT), hemoglobin (HB) level and platelet (PLT) counts of HD patients. Methods: A randomized controlled trial was conducted on HD patients at a private dialysis center in Rasht, Iran. Three omega-3 fatty acid supplement capsules (3 g/d) were administered daily for two months to patients in the intervention group (n = 55). The control group (n = 60) were given three placebo capsules containing medium chain triglyceride (MCT) oil, similar to the supplemental dose of the intervention group at the same period. Three parameters of HCT, HB and PLT were measured at baseline and after the intervention. Results: The PLT count decreased in the intervention group compared to the control group (173.38 ± 74.76 vs. 227.68 ± 86.58 103/mm3, F = 4.83, P = 0.03). No significant change was found on the levels of HCT and HB parameters between the two groups after the intervention. Conclusion: Omega-3 supplementation in HD patients may decrease the risk of forming blood clots in the blood vessels. Further studies are warranted.http://www.sciencedirect.com/science/article/pii/S2589909024000030Chronic kidney diseaseOmega-3 fatty acidsHemodialysisHemoglobinHematocritPlatelet |
| spellingShingle | Zahra Mahmoudi Zahra Roumi Seyed Ali Askarpour Zahra Mousavi Hanieh Shafaei Neda Valisoltani Mahsa Shapouri Seyed Reza Mirshafaei Pouya Mirzaee Khadijeh Abbasi Mobarakeh Elahe Taghavi Sufiani Zahra Mohammadi Nowdehi Zeynab Motiei Masoud Khosravi Saeid Doaei Maryam Gholamalizadeh The effects of omega-3 fatty acids supplementation on hemoglobin, hematocrit, and platelet levels of patients with ESRD condition undergoing dialysis Journal of Translational Autoimmunity Chronic kidney disease Omega-3 fatty acids Hemodialysis Hemoglobin Hematocrit Platelet |
| title | The effects of omega-3 fatty acids supplementation on hemoglobin, hematocrit, and platelet levels of patients with ESRD condition undergoing dialysis |
| title_full | The effects of omega-3 fatty acids supplementation on hemoglobin, hematocrit, and platelet levels of patients with ESRD condition undergoing dialysis |
| title_fullStr | The effects of omega-3 fatty acids supplementation on hemoglobin, hematocrit, and platelet levels of patients with ESRD condition undergoing dialysis |
| title_full_unstemmed | The effects of omega-3 fatty acids supplementation on hemoglobin, hematocrit, and platelet levels of patients with ESRD condition undergoing dialysis |
| title_short | The effects of omega-3 fatty acids supplementation on hemoglobin, hematocrit, and platelet levels of patients with ESRD condition undergoing dialysis |
| title_sort | effects of omega 3 fatty acids supplementation on hemoglobin hematocrit and platelet levels of patients with esrd condition undergoing dialysis |
| topic | Chronic kidney disease Omega-3 fatty acids Hemodialysis Hemoglobin Hematocrit Platelet |
| url | http://www.sciencedirect.com/science/article/pii/S2589909024000030 |
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