Neural and Psychological Predictors of Cognitive Enhancement and Impairment from Neurostimulation
Abstract Modulating the temporoparietal junction (TPJ), especially the right counterpart, shows promises in enhancing social cognitive ability. However, it is ambiguous whether the functional lateralization of TPJ determines people's responsiveness to brain stimulation. Here, this issue is inve...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-02-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.201902863 |
| _version_ | 1819018601932259328 |
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| author | Li‐Zhuang Yang Wei Zhang Wenjuan Wang Zhiyu Yang Hongzhi Wang Zhi‐De Deng Chuanfu Li Bensheng Qiu Da‐Ren Zhang Roi Cohen Kadosh Hai Li Xiaochu Zhang |
| author_facet | Li‐Zhuang Yang Wei Zhang Wenjuan Wang Zhiyu Yang Hongzhi Wang Zhi‐De Deng Chuanfu Li Bensheng Qiu Da‐Ren Zhang Roi Cohen Kadosh Hai Li Xiaochu Zhang |
| author_sort | Li‐Zhuang Yang |
| collection | DOAJ |
| description | Abstract Modulating the temporoparietal junction (TPJ), especially the right counterpart, shows promises in enhancing social cognitive ability. However, it is ambiguous whether the functional lateralization of TPJ determines people's responsiveness to brain stimulation. Here, this issue is investigated with an individual difference approach. Forty‐five participants attended three sessions of transcranial direct current stimulation (tDCS) experiments and one neuroimaging session. The results support the symmetric mechanism of left and right TPJ stimulation. First, the left and right TPJ stimulation effect are comparable in the group‐level analysis. Second, the individual‐level analysis reveals that a less right‐lateralized TPJ is associated with a higher level of responsiveness. Participants could be classified into positive responders showing cognitive enhancement and negative responders showing cognitive impairment due to stimulation. The positive responders show weaker connectivity between bilateral TPJ and the medial prefrontal cortex, which mediates the prediction of offline responsiveness by the lateralization and the social‐related trait. These findings call for a better characterization and predictive models for whom tDCS should be used for, and highlight the necessity and feasibility of prestimulation screening. |
| first_indexed | 2024-12-21T03:22:01Z |
| format | Article |
| id | doaj.art-615e393a966048d6a5118231a6db1da5 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-12-21T03:22:01Z |
| publishDate | 2020-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-615e393a966048d6a5118231a6db1da52022-12-21T19:17:41ZengWileyAdvanced Science2198-38442020-02-0174n/an/a10.1002/advs.201902863Neural and Psychological Predictors of Cognitive Enhancement and Impairment from NeurostimulationLi‐Zhuang Yang0Wei Zhang1Wenjuan Wang2Zhiyu Yang3Hongzhi Wang4Zhi‐De Deng5Chuanfu Li6Bensheng Qiu7Da‐Ren Zhang8Roi Cohen Kadosh9Hai Li10Xiaochu Zhang11Anhui Province Key Laboratory of Medical Physics and Technology Center of Medical Physics and Technology Hefei Institutes of Physical Science Chinese Academy of Sciences Hefei Anhui 230031 ChinaHefei National Laboratory for Physical Sciences at the Microscale, and School of Life Sciences University of Science and Technology of China Hefei Anhui 230027 ChinaHefei National Laboratory for Physical Sciences at the Microscale, and School of Life Sciences University of Science and Technology of China Hefei Anhui 230027 ChinaHefei National Laboratory for Physical Sciences at the Microscale, and School of Life Sciences University of Science and Technology of China Hefei Anhui 230027 ChinaAnhui Province Key Laboratory of Medical Physics and Technology Center of Medical Physics and Technology Hefei Institutes of Physical Science Chinese Academy of Sciences Hefei Anhui 230031 ChinaNoninvasive Neuromodulation Unit Experimental Therapeutics & Pathophysiology Branch Intramural Research Program National Institute of Mental Health National Institutes of Health Bethesda MD 20892‐9663 USALaboratory of Digital Medical Imaging Medical Imaging Center First Affiliated Hospital Anhui University of Chinese Medicine Hefei Anhui 230031 ChinaCenter for Biomedical Engineering University of Science and Technology of China Hefei Anhui 230027 ChinaHefei National Laboratory for Physical Sciences at the Microscale, and School of Life Sciences University of Science and Technology of China Hefei Anhui 230027 ChinaDepartment of Experimental Psychology University of Oxford Oxford OX1 3UD UKAnhui Province Key Laboratory of Medical Physics and Technology Center of Medical Physics and Technology Hefei Institutes of Physical Science Chinese Academy of Sciences Hefei Anhui 230031 ChinaHefei National Laboratory for Physical Sciences at the Microscale, and School of Life Sciences University of Science and Technology of China Hefei Anhui 230027 ChinaAbstract Modulating the temporoparietal junction (TPJ), especially the right counterpart, shows promises in enhancing social cognitive ability. However, it is ambiguous whether the functional lateralization of TPJ determines people's responsiveness to brain stimulation. Here, this issue is investigated with an individual difference approach. Forty‐five participants attended three sessions of transcranial direct current stimulation (tDCS) experiments and one neuroimaging session. The results support the symmetric mechanism of left and right TPJ stimulation. First, the left and right TPJ stimulation effect are comparable in the group‐level analysis. Second, the individual‐level analysis reveals that a less right‐lateralized TPJ is associated with a higher level of responsiveness. Participants could be classified into positive responders showing cognitive enhancement and negative responders showing cognitive impairment due to stimulation. The positive responders show weaker connectivity between bilateral TPJ and the medial prefrontal cortex, which mediates the prediction of offline responsiveness by the lateralization and the social‐related trait. These findings call for a better characterization and predictive models for whom tDCS should be used for, and highlight the necessity and feasibility of prestimulation screening.https://doi.org/10.1002/advs.201902863lateralizationmedial superior frontal gyrusneurostimulationtDCStemporoparietal junction |
| spellingShingle | Li‐Zhuang Yang Wei Zhang Wenjuan Wang Zhiyu Yang Hongzhi Wang Zhi‐De Deng Chuanfu Li Bensheng Qiu Da‐Ren Zhang Roi Cohen Kadosh Hai Li Xiaochu Zhang Neural and Psychological Predictors of Cognitive Enhancement and Impairment from Neurostimulation Advanced Science lateralization medial superior frontal gyrus neurostimulation tDCS temporoparietal junction |
| title | Neural and Psychological Predictors of Cognitive Enhancement and Impairment from Neurostimulation |
| title_full | Neural and Psychological Predictors of Cognitive Enhancement and Impairment from Neurostimulation |
| title_fullStr | Neural and Psychological Predictors of Cognitive Enhancement and Impairment from Neurostimulation |
| title_full_unstemmed | Neural and Psychological Predictors of Cognitive Enhancement and Impairment from Neurostimulation |
| title_short | Neural and Psychological Predictors of Cognitive Enhancement and Impairment from Neurostimulation |
| title_sort | neural and psychological predictors of cognitive enhancement and impairment from neurostimulation |
| topic | lateralization medial superior frontal gyrus neurostimulation tDCS temporoparietal junction |
| url | https://doi.org/10.1002/advs.201902863 |
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