Internal carotid artery stenosis: A novel surgical model for moyamoya syndrome.
Moyamoya is a cerebrovascular disorder characterized by progressive stenosis of the intracranial internal carotid arteries. There are two forms: Disease and Syndrome, with each characterized by the sub-population it affects. Moyamoya syndrome (MMS) is more prominent in adults in their 20's-40&#...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5764405?pdf=render |
| _version_ | 1818179965259087872 |
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| author | Jill M Roberts Michael E Maniskas Justin F Fraser Gregory J Bix |
| author_facet | Jill M Roberts Michael E Maniskas Justin F Fraser Gregory J Bix |
| author_sort | Jill M Roberts |
| collection | DOAJ |
| description | Moyamoya is a cerebrovascular disorder characterized by progressive stenosis of the intracranial internal carotid arteries. There are two forms: Disease and Syndrome, with each characterized by the sub-population it affects. Moyamoya syndrome (MMS) is more prominent in adults in their 20's-40's, and is often associated with autoimmune diseases. Currently, there are no surgical models for inducing moyamoya syndrome, so our aim was to develop a new animal model to study this relatively unknown cerebrovascular disease. Here, we demonstrate a new surgical technique termed internal carotid artery stenosis (ICAS), to mimic MMS using micro-coils on the proximal ICA. We tested for Moyamoya-like vasculopathies by fluorescently labelling the mouse cerebrovasculature with Di I for visualization and analysis of vessel diameter at the distal ICA and anastomoses on the cortical surface. Results show a significant narrowing of the distal ICA and anterior cerebral artery (ACA) in the Circle of Willis, as observed in humans. There is also a significant decrease in the number of anastomoses between the middle cerebral artery (MCA) and the ACA in the watershed region of the cortex. While further characterization is needed, this ICAS model can be applied to transgenic mice displaying co-morbidities as observed within the Moyamoya syndrome population, allowing a better understanding of the disease and development of novel treatments. |
| first_indexed | 2024-12-11T21:12:15Z |
| format | Article |
| id | doaj.art-616010a8c61e498b83abb2d863a5b88a |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T21:12:15Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-616010a8c61e498b83abb2d863a5b88a2022-12-22T00:50:40ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01131e019131210.1371/journal.pone.0191312Internal carotid artery stenosis: A novel surgical model for moyamoya syndrome.Jill M RobertsMichael E ManiskasJustin F FraserGregory J BixMoyamoya is a cerebrovascular disorder characterized by progressive stenosis of the intracranial internal carotid arteries. There are two forms: Disease and Syndrome, with each characterized by the sub-population it affects. Moyamoya syndrome (MMS) is more prominent in adults in their 20's-40's, and is often associated with autoimmune diseases. Currently, there are no surgical models for inducing moyamoya syndrome, so our aim was to develop a new animal model to study this relatively unknown cerebrovascular disease. Here, we demonstrate a new surgical technique termed internal carotid artery stenosis (ICAS), to mimic MMS using micro-coils on the proximal ICA. We tested for Moyamoya-like vasculopathies by fluorescently labelling the mouse cerebrovasculature with Di I for visualization and analysis of vessel diameter at the distal ICA and anastomoses on the cortical surface. Results show a significant narrowing of the distal ICA and anterior cerebral artery (ACA) in the Circle of Willis, as observed in humans. There is also a significant decrease in the number of anastomoses between the middle cerebral artery (MCA) and the ACA in the watershed region of the cortex. While further characterization is needed, this ICAS model can be applied to transgenic mice displaying co-morbidities as observed within the Moyamoya syndrome population, allowing a better understanding of the disease and development of novel treatments.http://europepmc.org/articles/PMC5764405?pdf=render |
| spellingShingle | Jill M Roberts Michael E Maniskas Justin F Fraser Gregory J Bix Internal carotid artery stenosis: A novel surgical model for moyamoya syndrome. PLoS ONE |
| title | Internal carotid artery stenosis: A novel surgical model for moyamoya syndrome. |
| title_full | Internal carotid artery stenosis: A novel surgical model for moyamoya syndrome. |
| title_fullStr | Internal carotid artery stenosis: A novel surgical model for moyamoya syndrome. |
| title_full_unstemmed | Internal carotid artery stenosis: A novel surgical model for moyamoya syndrome. |
| title_short | Internal carotid artery stenosis: A novel surgical model for moyamoya syndrome. |
| title_sort | internal carotid artery stenosis a novel surgical model for moyamoya syndrome |
| url | http://europepmc.org/articles/PMC5764405?pdf=render |
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