Heterogeneous pattern of gene expression driven by TTN mutation is involved in the construction of a prognosis model of lung squamous cell carcinoma
ObjectiveTo investigate the impact that TTN mutation had on the gene heterogeneity expression and prognosis in patients with lung adenocarcinoma.MethodsIn this study, the Cancer Genome Atlas (TCGA) dataset was used to analyze the TTN mutations in lung adenocarcinoma. Lung adenocarcinoma data was col...
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| Format: | Article |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.916568/full |
| _version_ | 1797860951692673024 |
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| author | Zhao Liu Zhao Liu Zhao Liu Xiaowen Zhao Ruihong Wang Xiangyue Tang Xiangyue Tang Yuxiang Zhao Yuxiang Zhao Yuxiang Zhao Guanghui Zhong Xin Peng Chunlin Zhang |
| author_facet | Zhao Liu Zhao Liu Zhao Liu Xiaowen Zhao Ruihong Wang Xiangyue Tang Xiangyue Tang Yuxiang Zhao Yuxiang Zhao Yuxiang Zhao Guanghui Zhong Xin Peng Chunlin Zhang |
| author_sort | Zhao Liu |
| collection | DOAJ |
| description | ObjectiveTo investigate the impact that TTN mutation had on the gene heterogeneity expression and prognosis in patients with lung adenocarcinoma.MethodsIn this study, the Cancer Genome Atlas (TCGA) dataset was used to analyze the TTN mutations in lung adenocarcinoma. Lung adenocarcinoma data was collected from the TCGA database, clinical information of patients was analyzed, and bioinformatics statistical methods were applied for mutation analysis and prognosis survival analysis. The results were verified using the GEO dataset.ResultsThe incidence of TTN mutations in lung adenocarcinoma was found to be 73%, and it was related to the prognosis of lung adenocarcinoma. Ten genes were screened with significant contributions to prognosis. A prognosis model was constructed and verified by LASSO COX analysis in the TCGA and GEO datasets based on these ten beneficial factors. The independent prognostic factor H2BC9 for TTN mutation-driven gene heterogeneity expression was screened through multi-factor COX regression analysis.ConclusionOur data showed that the gene heterogeneity expression, which was driven by TTN mutations, prolonged the survival of lung adenocarcinoma patients and provided valuable clues for the prognosis of TTN gene mutations in lung adenocarcinoma. |
| first_indexed | 2024-04-09T21:54:11Z |
| format | Article |
| id | doaj.art-616074a460294232953b32cc04c968cf |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-09T21:54:11Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-616074a460294232953b32cc04c968cf2023-03-24T09:38:26ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-03-011310.3389/fonc.2023.916568916568Heterogeneous pattern of gene expression driven by TTN mutation is involved in the construction of a prognosis model of lung squamous cell carcinomaZhao Liu0Zhao Liu1Zhao Liu2Xiaowen Zhao3Ruihong Wang4Xiangyue Tang5Xiangyue Tang6Yuxiang Zhao7Yuxiang Zhao8Yuxiang Zhao9Guanghui Zhong10Xin Peng11Chunlin Zhang12Ningbo Municipal Hospital of Traditional Chinese Medicine (TCM), Affiliated Hospital of Zhejiang Chinese Medical University, Ningbo, ChinaUnited New Drug Research and Development Center, Biotrans Technology Co., LTD., Ningbo, ChinaInstitute of Bioengineering, Biotrans Technology Co., LTD., Shanghai, ChinaQingdao Central Hospital, The Second Affiliated Hospital of Medical College of Qingdao University, Qingdao, ChinaQingdao Central Hospital, The Second Affiliated Hospital of Medical College of Qingdao University, Qingdao, ChinaUnited New Drug Research and Development Center, Biotrans Technology Co., LTD., Ningbo, ChinaInstitute of Bioengineering, Biotrans Technology Co., LTD., Shanghai, ChinaNingbo Municipal Hospital of Traditional Chinese Medicine (TCM), Affiliated Hospital of Zhejiang Chinese Medical University, Ningbo, ChinaUnited New Drug Research and Development Center, Biotrans Technology Co., LTD., Ningbo, ChinaInstitute of Bioengineering, Biotrans Technology Co., LTD., Shanghai, ChinaNingbo Municipal Hospital of Traditional Chinese Medicine (TCM), Affiliated Hospital of Zhejiang Chinese Medical University, Ningbo, ChinaNingbo Municipal Hospital of Traditional Chinese Medicine (TCM), Affiliated Hospital of Zhejiang Chinese Medical University, Ningbo, ChinaQingdao Central Hospital, The Second Affiliated Hospital of Medical College of Qingdao University, Qingdao, ChinaObjectiveTo investigate the impact that TTN mutation had on the gene heterogeneity expression and prognosis in patients with lung adenocarcinoma.MethodsIn this study, the Cancer Genome Atlas (TCGA) dataset was used to analyze the TTN mutations in lung adenocarcinoma. Lung adenocarcinoma data was collected from the TCGA database, clinical information of patients was analyzed, and bioinformatics statistical methods were applied for mutation analysis and prognosis survival analysis. The results were verified using the GEO dataset.ResultsThe incidence of TTN mutations in lung adenocarcinoma was found to be 73%, and it was related to the prognosis of lung adenocarcinoma. Ten genes were screened with significant contributions to prognosis. A prognosis model was constructed and verified by LASSO COX analysis in the TCGA and GEO datasets based on these ten beneficial factors. The independent prognostic factor H2BC9 for TTN mutation-driven gene heterogeneity expression was screened through multi-factor COX regression analysis.ConclusionOur data showed that the gene heterogeneity expression, which was driven by TTN mutations, prolonged the survival of lung adenocarcinoma patients and provided valuable clues for the prognosis of TTN gene mutations in lung adenocarcinoma.https://www.frontiersin.org/articles/10.3389/fonc.2023.916568/fullbioinformaticslung squamous carcinomaTTNgene mutationprognostic survival |
| spellingShingle | Zhao Liu Zhao Liu Zhao Liu Xiaowen Zhao Ruihong Wang Xiangyue Tang Xiangyue Tang Yuxiang Zhao Yuxiang Zhao Yuxiang Zhao Guanghui Zhong Xin Peng Chunlin Zhang Heterogeneous pattern of gene expression driven by TTN mutation is involved in the construction of a prognosis model of lung squamous cell carcinoma Frontiers in Oncology bioinformatics lung squamous carcinoma TTN gene mutation prognostic survival |
| title | Heterogeneous pattern of gene expression driven by TTN mutation is involved in the construction of a prognosis model of lung squamous cell carcinoma |
| title_full | Heterogeneous pattern of gene expression driven by TTN mutation is involved in the construction of a prognosis model of lung squamous cell carcinoma |
| title_fullStr | Heterogeneous pattern of gene expression driven by TTN mutation is involved in the construction of a prognosis model of lung squamous cell carcinoma |
| title_full_unstemmed | Heterogeneous pattern of gene expression driven by TTN mutation is involved in the construction of a prognosis model of lung squamous cell carcinoma |
| title_short | Heterogeneous pattern of gene expression driven by TTN mutation is involved in the construction of a prognosis model of lung squamous cell carcinoma |
| title_sort | heterogeneous pattern of gene expression driven by ttn mutation is involved in the construction of a prognosis model of lung squamous cell carcinoma |
| topic | bioinformatics lung squamous carcinoma TTN gene mutation prognostic survival |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.916568/full |
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