Development of an In Vitro Assessment Method for Chemotherapy-Induced Peripheral Neuropathy (CIPN) by Integrating a Microphysiological System (MPS) with Morphological Deep Learning of Soma and Axonal Images

Development of an In Vitro Assessment Method for Chemotherapy-Induced Peripheral Neuropathy (CIPN) by Integrating a Microphysiological System (MPS) with Morphological Deep Learning of Soma and Axonal Images

Several anticancer drugs used in cancer therapy induce chemotherapy-induced peripheral neuropathy (CIPN), leading to dose reduction or therapy cessation. Consequently, there is a demand for an in vitro assessment method to predict CIPN and mechanisms of action (MoA) in drug candidate compounds. In t...

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Bibliographic Details
Main Authors: Kazuki Matsuda, Xiaobo Han, Naoki Matsuda, Makoto Yamanaka, Ikuro Suzuki
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Toxics
Subjects:
chemotherapy
paclitaxel
oxaliplatin
vincristine
bortezomib
suramin
Online Access:https://www.mdpi.com/2305-6304/11/10/848

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