Impact of airway closure and lung collapse on inhaled nitric oxide effect in acute lung injury: an experimental study

Abstract Background Efficacy of inhaled therapy such as Nitric Oxide (iNO) during mechanical ventilation may depend on airway patency. We hypothesized that airway closure and lung collapse, countered by positive end-expiratory pressure (PEEP), influence iNO efficacy. This could support the role of a...

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Main Authors: Mariangela Pellegrini, Mayson L. A. Sousa, Sebastian Dubo, Luca S. Menga, Vanessa Hsing, Martin Post, Laurent J. Brochard
פורמט: Article
שפה:English
יצא לאור: SpringerOpen 2024-09-01
סדרה:Annals of Intensive Care
נושאים:
גישה מקוונת:https://doi.org/10.1186/s13613-024-01378-z