Comparison of the ICC location in the gallbladder wall in patients with cholelithiasis and patients with non-calculous changes
Interstitial cells of Cajal (ICC) were first described by Santiago Ramon y Cajal over 100 years ago. They are thought to play an important role in the regulation of gastrointestinal motility. There is increasing evidence that the decline in their number in the gallbladder wall contributes to the for...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2019-12-01
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| Series: | Polish Journal of Pathology |
| Subjects: | |
| Online Access: | https://www.termedia.pl/Comparison-of-the-ICC-location-in-the-gallbladder-wall-in-patients-with-cholelithiasis-and-patients-with-non-calculous-changes,55,38850,1,1.html |
| _version_ | 1818412233207578624 |
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| author | Joanna Spętana Artur Lipiński Michał Jeleń |
| author_facet | Joanna Spętana Artur Lipiński Michał Jeleń |
| author_sort | Joanna Spętana |
| collection | DOAJ |
| description | Interstitial cells of Cajal (ICC) were first described by Santiago Ramon y Cajal over 100 years ago. They are thought to play an important role in the regulation of gastrointestinal motility. There is increasing evidence that the decline in their number in the gallbladder wall contributes to the formation of concrements. The aim of the study was to determine the exact location of interstitial cells of Cajal in the gallbladder wall in patients with calculous and non-calculous cholecystitis. Sixty-eight patients were examined, of whom 50 were cases of cholelithiasis and 18 were of non-calculous cholecystitis. The technique of immunohistochemistry with the CD117 antibody was used to determine the cells of Cajal, while to distinguish them from mast cells the technique with mast cell tryptase (MCT) was applied. Redistribution of the interstitial cells of Cajal from the muscle membrane to lamina propria of mucous tissue was observed in the cases of cholelithiasis, while in the group of non-calculous cholecystitis most of the ICC was located within the muscle tissue. |
| first_indexed | 2024-12-14T10:44:03Z |
| format | Article |
| id | doaj.art-6163d341d29b42dd940967a85a184f42 |
| institution | Directory Open Access Journal |
| issn | 1233-9687 2084-9869 |
| language | English |
| last_indexed | 2024-12-14T10:44:03Z |
| publishDate | 2019-12-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Polish Journal of Pathology |
| spelling | doaj.art-6163d341d29b42dd940967a85a184f422022-12-21T23:05:32ZengTermedia Publishing HousePolish Journal of Pathology1233-96872084-98692019-12-0170320520910.5114/pjp.2019.9039738850Comparison of the ICC location in the gallbladder wall in patients with cholelithiasis and patients with non-calculous changesJoanna SpętanaArtur LipińskiMichał JeleńInterstitial cells of Cajal (ICC) were first described by Santiago Ramon y Cajal over 100 years ago. They are thought to play an important role in the regulation of gastrointestinal motility. There is increasing evidence that the decline in their number in the gallbladder wall contributes to the formation of concrements. The aim of the study was to determine the exact location of interstitial cells of Cajal in the gallbladder wall in patients with calculous and non-calculous cholecystitis. Sixty-eight patients were examined, of whom 50 were cases of cholelithiasis and 18 were of non-calculous cholecystitis. The technique of immunohistochemistry with the CD117 antibody was used to determine the cells of Cajal, while to distinguish them from mast cells the technique with mast cell tryptase (MCT) was applied. Redistribution of the interstitial cells of Cajal from the muscle membrane to lamina propria of mucous tissue was observed in the cases of cholelithiasis, while in the group of non-calculous cholecystitis most of the ICC was located within the muscle tissue.https://www.termedia.pl/Comparison-of-the-ICC-location-in-the-gallbladder-wall-in-patients-with-cholelithiasis-and-patients-with-non-calculous-changes,55,38850,1,1.htmlicc interstitial cells of cajal distribution gallbladder |
| spellingShingle | Joanna Spętana Artur Lipiński Michał Jeleń Comparison of the ICC location in the gallbladder wall in patients with cholelithiasis and patients with non-calculous changes Polish Journal of Pathology icc interstitial cells of cajal distribution gallbladder |
| title | Comparison of the ICC location in the gallbladder wall in patients with cholelithiasis and patients with non-calculous changes |
| title_full | Comparison of the ICC location in the gallbladder wall in patients with cholelithiasis and patients with non-calculous changes |
| title_fullStr | Comparison of the ICC location in the gallbladder wall in patients with cholelithiasis and patients with non-calculous changes |
| title_full_unstemmed | Comparison of the ICC location in the gallbladder wall in patients with cholelithiasis and patients with non-calculous changes |
| title_short | Comparison of the ICC location in the gallbladder wall in patients with cholelithiasis and patients with non-calculous changes |
| title_sort | comparison of the icc location in the gallbladder wall in patients with cholelithiasis and patients with non calculous changes |
| topic | icc interstitial cells of cajal distribution gallbladder |
| url | https://www.termedia.pl/Comparison-of-the-ICC-location-in-the-gallbladder-wall-in-patients-with-cholelithiasis-and-patients-with-non-calculous-changes,55,38850,1,1.html |
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