Structural Changes of Zn(II)bleomycin Complexes When Bound to DNA Hairpins Containing the 5′-GT-3′ and 5′-GC-3′ Binding Sites, Studied through NMR Spectroscopy

Structural Changes of Zn(II)bleomycin Complexes When Bound to DNA Hairpins Containing the 5′-GT-3′ and 5′-GC-3′ Binding Sites, Studied through NMR Spectroscopy

We have previously investigated the diverse levels of disruption caused by Zn(II)BLMs with different C-termini to DNA hairpins containing 5′-GC-3′ and 5′-GT-3′ binding sites. The results of this investigation indicated that both the DNA-binding site and the bleomycin C-termini have an impact on the...

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Bibliographic Details
Main Authors: Shelby E. Follett, Sally A. Murray, Azure D. Ingersoll, Teresa M. Reilly, Teresa E. Lehmann
Format: Article
Language:English
Published: MDPI AG 2017-12-01
Series:Magnetochemistry
Subjects:
DNA
NMR
pulmonary fibrosis
anticancer drug
structure-function
Online Access:https://www.mdpi.com/2312-7481/4/1/4

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