Hypocalcemia in Covid-19: A Prognostic Marker for Severe Disease
Background & Objective: Previous studies have addressed the electrolyte abnormalitiessuch as hypocalcemiain COVID-19 patients. We aimed to compare the laboratory findings especially the electrolyte levels amongCOVID-19 patients and healthy controls and evaluate their prognostic values. Material...
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| Format: | Article |
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Iranian Society of Pathology
2020-10-01
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| Series: | Iranian Journal of Pathology |
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| Online Access: | https://ijp.iranpath.org/article_46937_cbfa5fa4e2e9789bc9714b87c3dd0c1a.pdf |
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| author | Ahmad Raesi Ebrahim Saedi Dezaki Hamideh Moosapour Farzaneh Saeidifard Zahra Habibi Fereidoun Rahmani Soleiman Kheiri Elham Taheri |
| author_facet | Ahmad Raesi Ebrahim Saedi Dezaki Hamideh Moosapour Farzaneh Saeidifard Zahra Habibi Fereidoun Rahmani Soleiman Kheiri Elham Taheri |
| author_sort | Ahmad Raesi |
| collection | DOAJ |
| description | Background & Objective: Previous studies have addressed the electrolyte abnormalitiessuch as hypocalcemiain COVID-19 patients. We aimed to compare the laboratory findings especially the electrolyte levels amongCOVID-19 patients and healthy controls and evaluate their prognostic values. Materials and Methods: This case-control study included 91 COVID-19 patients and 169 healthy individuals. Their laboratory parameters including electrolytes, albumin, liver enzymes, complete blood count, vitamin D, and parathyroid hormone (PTH) were compared. We also analyzed the association between these markers and the major outcomes including severity, mortality and hospitalization. Results: Among patients with COVID-19, 59.3% of the patients had hypocalcemia on admission while in control group only 32.5% had low calcium level (OR=3.02, 95% CI: 1.79-5.13, p <0.001). The rates of death and ICU admission were significantly higher among the patients in hypocalcemic group than those of eucalcemic group (85.7% vs 14.3% and 33.3% Vs 9.1%, respectively). However, there was no significant difference in the mean PTH and vitamin D levels between the two groups. In terms of the severity of the infection, 74.1% of patients in hypocalcemic group had a severe infection while 24.3% of the patients in eucalcemic group were diagnosed with severe infection (OR=8.89, 95% CI: 3.38-23.37, p <0.001). Conclusion: Patients with COVID-19 had considerable laboratory abnormalities including hypocalcemia. The hypocalcemia was also associated with worse major clinical outcomes and higher mortality risk. |
| first_indexed | 2024-12-22T00:06:05Z |
| format | Article |
| id | doaj.art-6164f2da88834316bcb5f3b17b4a7ea0 |
| institution | Directory Open Access Journal |
| issn | 1735-5303 2345-3656 |
| language | English |
| last_indexed | 2024-12-22T00:06:05Z |
| publishDate | 2020-10-01 |
| publisher | Iranian Society of Pathology |
| record_format | Article |
| series | Iranian Journal of Pathology |
| spelling | doaj.art-6164f2da88834316bcb5f3b17b4a7ea02022-12-21T18:45:34ZengIranian Society of PathologyIranian Journal of Pathology1735-53032345-36562020-10-0116214415310.30699/ijp.2020.130491.244246937Hypocalcemia in Covid-19: A Prognostic Marker for Severe DiseaseAhmad Raesi0Ebrahim Saedi Dezaki1Hamideh Moosapour2Farzaneh Saeidifard3Zahra Habibi4Fereidoun Rahmani5Soleiman Kheiri6Elham Taheri7Department of Internal Medicine, Clinical Research Development Unit, Hajar Hospital, Shahrekord University of Medical Sciences, Shahrekord, IranDepartment of Parasitology, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, IranEvidence Based Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, IranDepartment of Medicine, Northwell Health-Lenox Hill Hospital, Zucker School of Medicine at Hofstra/Northwell, New York, United States of America (USA)Department of Internal Medicine, Clinical Research Development Unit, Hajar Hospital, Shahrekord University of Medical Sciences, Shahrekord, IranDepartment of Infectious Disease, Clinical Research Development Unit, Hajar Hospital, Shahrekord University of Medical Sciences, Shahrekord, IranDepartment of Epidemiology and Biostatistics, School of Health, Modeling in Health Research Center, Shahrekord University of Medical Sciences, Shahrekord, IranMolecular Pathology and Cytogenetic Ward, Pathology Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranBackground & Objective: Previous studies have addressed the electrolyte abnormalitiessuch as hypocalcemiain COVID-19 patients. We aimed to compare the laboratory findings especially the electrolyte levels amongCOVID-19 patients and healthy controls and evaluate their prognostic values. Materials and Methods: This case-control study included 91 COVID-19 patients and 169 healthy individuals. Their laboratory parameters including electrolytes, albumin, liver enzymes, complete blood count, vitamin D, and parathyroid hormone (PTH) were compared. We also analyzed the association between these markers and the major outcomes including severity, mortality and hospitalization. Results: Among patients with COVID-19, 59.3% of the patients had hypocalcemia on admission while in control group only 32.5% had low calcium level (OR=3.02, 95% CI: 1.79-5.13, p <0.001). The rates of death and ICU admission were significantly higher among the patients in hypocalcemic group than those of eucalcemic group (85.7% vs 14.3% and 33.3% Vs 9.1%, respectively). However, there was no significant difference in the mean PTH and vitamin D levels between the two groups. In terms of the severity of the infection, 74.1% of patients in hypocalcemic group had a severe infection while 24.3% of the patients in eucalcemic group were diagnosed with severe infection (OR=8.89, 95% CI: 3.38-23.37, p <0.001). Conclusion: Patients with COVID-19 had considerable laboratory abnormalities including hypocalcemia. The hypocalcemia was also associated with worse major clinical outcomes and higher mortality risk.https://ijp.iranpath.org/article_46937_cbfa5fa4e2e9789bc9714b87c3dd0c1a.pdfalbumincovid-19clinical severityelectrolyte -imbalanceshypocalcemiaparathyroid hormoneprognosisvitamin d |
| spellingShingle | Ahmad Raesi Ebrahim Saedi Dezaki Hamideh Moosapour Farzaneh Saeidifard Zahra Habibi Fereidoun Rahmani Soleiman Kheiri Elham Taheri Hypocalcemia in Covid-19: A Prognostic Marker for Severe Disease Iranian Journal of Pathology albumin covid-19 clinical severity electrolyte -imbalances hypocalcemia parathyroid hormone prognosis vitamin d |
| title | Hypocalcemia in Covid-19: A Prognostic Marker for Severe Disease |
| title_full | Hypocalcemia in Covid-19: A Prognostic Marker for Severe Disease |
| title_fullStr | Hypocalcemia in Covid-19: A Prognostic Marker for Severe Disease |
| title_full_unstemmed | Hypocalcemia in Covid-19: A Prognostic Marker for Severe Disease |
| title_short | Hypocalcemia in Covid-19: A Prognostic Marker for Severe Disease |
| title_sort | hypocalcemia in covid 19 a prognostic marker for severe disease |
| topic | albumin covid-19 clinical severity electrolyte -imbalances hypocalcemia parathyroid hormone prognosis vitamin d |
| url | https://ijp.iranpath.org/article_46937_cbfa5fa4e2e9789bc9714b87c3dd0c1a.pdf |
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