Tirzepatide induces a thermogenic-like amino acid signature in brown adipose tissue

Tirzepatide induces a thermogenic-like amino acid signature in brown adipose tissue

Objectives: Tirzepatide, a dual GIP and GLP-1 receptor agonist, delivered superior glycemic control and weight loss compared to selective GLP-1 receptor (GLP-1R) agonism in patients with type 2 diabetes (T2D). These results have fueled mechanistic studies focused on understanding how tirzepatide ach...

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Bibliographic Details
Main Authors: Ricardo J. Samms, GuoFang Zhang, Wentao He, Olga Ilkayeva, Brian A. Droz, Steven M. Bauer, Cynthia Stutsman, Valentina Pirro, Kyla A. Collins, Ellen C. Furber, Tamer Coskun, Kyle W. Sloop, Joseph T. Brozinick, Christopher B. Newgard
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Molecular Metabolism
Subjects:
Tirzepatide
GIPR
GLP-1R
BCAAs
BCKAs
BAT
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877822001193

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http://www.sciencedirect.com/science/article/pii/S2212877822001193

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