The Search for Biomarkers in Fibromyalgia
Fibromyalgia is the most common of the central sensitivity syndromes affecting 2–5% of the adult population in the United States. This pain amplification syndrome has enormous societal impact as measured by work absenteeism, decreased work productivity, disability and injury compensation and over-ut...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/2/156 |
| _version_ | 1827598897580605440 |
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| author | Kevin V. Hackshaw |
| author_facet | Kevin V. Hackshaw |
| author_sort | Kevin V. Hackshaw |
| collection | DOAJ |
| description | Fibromyalgia is the most common of the central sensitivity syndromes affecting 2–5% of the adult population in the United States. This pain amplification syndrome has enormous societal impact as measured by work absenteeism, decreased work productivity, disability and injury compensation and over-utilization of healthcare resources. Multiple studies have shown that early diagnosis of this condition can improve patient outlook and redirect valuable healthcare resources towards more appropriate targeted therapy. Efforts have been made towards improving diagnostic accuracy through updated criteria. The search for biomarkers for diagnosis and verification of Fibromyalgia is an ongoing process. Inadequacies with current diagnostic criteria for this condition have fueled these efforts for identification of a reproducible marker that can verify this disease in a highly sensitive, specific and reproducible manner. This review focuses on areas of research for biomarkers in fibromyalgia and suggests that future efforts might benefit from approaches that utilize arrays of biomarkers to identify this disorder that presents with a diverse clinical phenotype. |
| first_indexed | 2024-03-09T04:02:28Z |
| format | Article |
| id | doaj.art-616b920c58d147b8b3f188a83d3810be |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T04:02:28Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-616b920c58d147b8b3f188a83d3810be2023-12-03T14:11:36ZengMDPI AGDiagnostics2075-44182021-01-0111215610.3390/diagnostics11020156The Search for Biomarkers in FibromyalgiaKevin V. Hackshaw0Department of Internal Medicine, Division of Rheumatology, Dell Medical School at the University of Texas at Austin, 1601 Trinity St, Austin, TX 78712, USAFibromyalgia is the most common of the central sensitivity syndromes affecting 2–5% of the adult population in the United States. This pain amplification syndrome has enormous societal impact as measured by work absenteeism, decreased work productivity, disability and injury compensation and over-utilization of healthcare resources. Multiple studies have shown that early diagnosis of this condition can improve patient outlook and redirect valuable healthcare resources towards more appropriate targeted therapy. Efforts have been made towards improving diagnostic accuracy through updated criteria. The search for biomarkers for diagnosis and verification of Fibromyalgia is an ongoing process. Inadequacies with current diagnostic criteria for this condition have fueled these efforts for identification of a reproducible marker that can verify this disease in a highly sensitive, specific and reproducible manner. This review focuses on areas of research for biomarkers in fibromyalgia and suggests that future efforts might benefit from approaches that utilize arrays of biomarkers to identify this disorder that presents with a diverse clinical phenotype.https://www.mdpi.com/2075-4418/11/2/156fibromyalgiavibrational spectroscopybiomarkercytokinescentral sensitization |
| spellingShingle | Kevin V. Hackshaw The Search for Biomarkers in Fibromyalgia Diagnostics fibromyalgia vibrational spectroscopy biomarker cytokines central sensitization |
| title | The Search for Biomarkers in Fibromyalgia |
| title_full | The Search for Biomarkers in Fibromyalgia |
| title_fullStr | The Search for Biomarkers in Fibromyalgia |
| title_full_unstemmed | The Search for Biomarkers in Fibromyalgia |
| title_short | The Search for Biomarkers in Fibromyalgia |
| title_sort | search for biomarkers in fibromyalgia |
| topic | fibromyalgia vibrational spectroscopy biomarker cytokines central sensitization |
| url | https://www.mdpi.com/2075-4418/11/2/156 |
| work_keys_str_mv | AT kevinvhackshaw thesearchforbiomarkersinfibromyalgia AT kevinvhackshaw searchforbiomarkersinfibromyalgia |