Extrapulmonary Sarcoidosis with Multiple-Organ Involvement
INTRODUCTION[|]In cases of pulmonary sarcoidosis, extrapulmonary involvement is not uncommon. The skin, eyes, and lymph nodes are the most common sites of extrapulmonary involvement, and multiple organs may be involved at the same time. In this study, patients with extrapulmonary sarcoidosis were in...
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| Format: | Article |
| Language: | English |
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KARE Publishing
2018-05-01
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| Series: | Southern Clinics of Istanbul Eurasia |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=scie&un=SCIE-42650 |
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| author | Emine Aksoy Eylem Tunçay Birsen Ocakli Sümeyye Alparslan Bekir Sinem Güngör Fatma Tokgöz Akyıl Pakize Sucu Dilek Yavuz Murat Yalçınsoy |
| author_facet | Emine Aksoy Eylem Tunçay Birsen Ocakli Sümeyye Alparslan Bekir Sinem Güngör Fatma Tokgöz Akyıl Pakize Sucu Dilek Yavuz Murat Yalçınsoy |
| author_sort | Emine Aksoy |
| collection | DOAJ |
| description | INTRODUCTION[|]In cases of pulmonary sarcoidosis, extrapulmonary involvement is not uncommon. The skin, eyes, and lymph nodes are the most common sites of extrapulmonary involvement, and multiple organs may be involved at the same time. In this study, patients with extrapulmonary sarcoidosis were investigated in terms of the localization of involvement.[¤]METHODS[|]Patients diagnosed with sarcoidosis between 1994 and 2015 were evaluated retrospectively. Demographic characteristics, symptoms, organ involvement, diagnostic methods, and the length of time between the diagnosis of sarcoidosis and additional organ involvement were recorded. The patients were consulted to the departments of dermatology, ophthalmology, and cardiology, and a chest X-ray, high-resolution computed tomography, and abdominal ultrasound examinations were performed.[¤]RESULTS[|]Extrapulmonary involvement was detected in 144 of a total of 337 sarcoidosis patients. In 92% of those patients with extrapulmonary involvement, there was accompanying pulmonary involvement. Women made up 75% of the group, and the mean age was 43 years. The most commonly detected extrapulmonary involvement was of the skin (n=41), followed by erythema nodosum (n=37), and involvement of the liver (n=24), lymph nodes (n=20), spleen (n=18), and salivary/parotid gland (n=15). The most frequent diagnostic method used was mediastinoscopy (n=41), followed by a skin biopsy (n=23), and a transbronchial lung biopsy (n=19). Of the 26 (18%) patients who had multiple-organ involvement, 2 were diagnosed as stage 0, 14 were stage 1, 9 were stage 2, and 1 was stage 3. The mean length of time before a diagnosis of extrapulmonary involvement was 24 days.[¤]DISCUSSION AND CONCLUSION[|]If there is extrapulmonary involvement in a case of sarcoidosis, it should be kept in mind that more than 1 organ system may be involved and the relevant additional tests may be required.[¤] |
| first_indexed | 2024-04-10T11:54:48Z |
| format | Article |
| id | doaj.art-616bf736a0c0433b8e418c6aa05bd219 |
| institution | Directory Open Access Journal |
| issn | 2587-0998 |
| language | English |
| last_indexed | 2024-04-10T11:54:48Z |
| publishDate | 2018-05-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | Southern Clinics of Istanbul Eurasia |
| spelling | doaj.art-616bf736a0c0433b8e418c6aa05bd2192023-02-15T16:16:52ZengKARE PublishingSouthern Clinics of Istanbul Eurasia2587-09982018-05-01291303510.14744/scie.2018.42650SCIE-42650Extrapulmonary Sarcoidosis with Multiple-Organ InvolvementEmine Aksoy0Eylem Tunçay1Birsen Ocakli2Sümeyye Alparslan Bekir3Sinem Güngör4Fatma Tokgöz Akyıl5Pakize Sucu6Dilek Yavuz7Murat Yalçınsoy8Department of Chest Diseases, University of Health Sciences Süreyyapaşa Chest Diseases and Thoracic Surgery Training and Research Hospital, İstanbul, TurkeyDepartment of Chest Diseases, University of Health Sciences Süreyyapaşa Chest Diseases and Thoracic Surgery Training and Research Hospital, İstanbul, TurkeyDepartment of Chest Diseases, University of Health Sciences Süreyyapaşa Chest Diseases and Thoracic Surgery Training and Research Hospital, İstanbul, TurkeyDepartment of Chest Diseases, University of Health Sciences Süreyyapaşa Chest Diseases and Thoracic Surgery Training and Research Hospital, İstanbul, TurkeyDepartment of Chest Diseases, University of Health Sciences Süreyyapaşa Chest Diseases and Thoracic Surgery Training and Research Hospital, İstanbul, TurkeyDepartment of Chest Diseases, University of Health Sciences Süreyyapaşa Chest Diseases and Thoracic Surgery Training and Research Hospital, İstanbul, TurkeyDepartment of Chest Diseases, University of Health Sciences Süreyyapaşa Chest Diseases and Thoracic Surgery Training and Research Hospital, İstanbul, TurkeyDepartment of Chest Diseases, University of Health Sciences Süreyyapaşa Chest Diseases and Thoracic Surgery Training and Research Hospital, İstanbul, TurkeyDepartment of Pulmonary Disease, İnönü University Faculty of Medicine, Malatya, TurkeyINTRODUCTION[|]In cases of pulmonary sarcoidosis, extrapulmonary involvement is not uncommon. The skin, eyes, and lymph nodes are the most common sites of extrapulmonary involvement, and multiple organs may be involved at the same time. In this study, patients with extrapulmonary sarcoidosis were investigated in terms of the localization of involvement.[¤]METHODS[|]Patients diagnosed with sarcoidosis between 1994 and 2015 were evaluated retrospectively. Demographic characteristics, symptoms, organ involvement, diagnostic methods, and the length of time between the diagnosis of sarcoidosis and additional organ involvement were recorded. The patients were consulted to the departments of dermatology, ophthalmology, and cardiology, and a chest X-ray, high-resolution computed tomography, and abdominal ultrasound examinations were performed.[¤]RESULTS[|]Extrapulmonary involvement was detected in 144 of a total of 337 sarcoidosis patients. In 92% of those patients with extrapulmonary involvement, there was accompanying pulmonary involvement. Women made up 75% of the group, and the mean age was 43 years. The most commonly detected extrapulmonary involvement was of the skin (n=41), followed by erythema nodosum (n=37), and involvement of the liver (n=24), lymph nodes (n=20), spleen (n=18), and salivary/parotid gland (n=15). The most frequent diagnostic method used was mediastinoscopy (n=41), followed by a skin biopsy (n=23), and a transbronchial lung biopsy (n=19). Of the 26 (18%) patients who had multiple-organ involvement, 2 were diagnosed as stage 0, 14 were stage 1, 9 were stage 2, and 1 was stage 3. The mean length of time before a diagnosis of extrapulmonary involvement was 24 days.[¤]DISCUSSION AND CONCLUSION[|]If there is extrapulmonary involvement in a case of sarcoidosis, it should be kept in mind that more than 1 organ system may be involved and the relevant additional tests may be required.[¤]https://jag.journalagent.com/z4/download_fulltext.asp?pdir=scie&un=SCIE-42650diagnosisextrapulmonary involvement; sarcoidosis. |
| spellingShingle | Emine Aksoy Eylem Tunçay Birsen Ocakli Sümeyye Alparslan Bekir Sinem Güngör Fatma Tokgöz Akyıl Pakize Sucu Dilek Yavuz Murat Yalçınsoy Extrapulmonary Sarcoidosis with Multiple-Organ Involvement Southern Clinics of Istanbul Eurasia diagnosis extrapulmonary involvement; sarcoidosis. |
| title | Extrapulmonary Sarcoidosis with Multiple-Organ Involvement |
| title_full | Extrapulmonary Sarcoidosis with Multiple-Organ Involvement |
| title_fullStr | Extrapulmonary Sarcoidosis with Multiple-Organ Involvement |
| title_full_unstemmed | Extrapulmonary Sarcoidosis with Multiple-Organ Involvement |
| title_short | Extrapulmonary Sarcoidosis with Multiple-Organ Involvement |
| title_sort | extrapulmonary sarcoidosis with multiple organ involvement |
| topic | diagnosis extrapulmonary involvement; sarcoidosis. |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=scie&un=SCIE-42650 |
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