Method for Quantitative Broadband Diffuse Optical Spectroscopy of Tumor-Like Inclusions
A hybrid reflectance-based diffuse optical imaging (DOI) technique combining discrete wavelength frequency-domain (FD) near-infrared spectroscopy (NIRS) with broadband continuous wave NIRS measurements was developed to quantify the broadband optical properties of deep tumor-like inclusions. This met...
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| Format: | Article |
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MDPI AG
2020-02-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/10/4/1419 |
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| author | Sandhya Vasudevan Farnoush Forghani Chris Campbell Savannah Bedford Thomas D. O’Sullivan |
| author_facet | Sandhya Vasudevan Farnoush Forghani Chris Campbell Savannah Bedford Thomas D. O’Sullivan |
| author_sort | Sandhya Vasudevan |
| collection | DOAJ |
| description | A hybrid reflectance-based diffuse optical imaging (DOI) technique combining discrete wavelength frequency-domain (FD) near-infrared spectroscopy (NIRS) with broadband continuous wave NIRS measurements was developed to quantify the broadband optical properties of deep tumor-like inclusions. This method was developed to more accurately measure the broadband optical properties of human tumors using a compact handheld imaging probe and without requiring a priori spectral constraints. We simulated the reconstruction of absorption and scattering spectra (650−1000 nm) of human breast tumors in a homogeneous background at depths of 0 to 10 mm. The hybrid DOI technique demonstrated enhanced performance in reconstruction of optical absorption with a mean accuracy over all 71 wavelengths of 8.39% versus 32.26% for a 10 mm deep tumor with the topographic DOI method. The new hybrid technique was also tested and validated on two heterogeneous tissue-simulating phantoms with inclusion depths of 2, 7, and 9 mm. The mean optical absorption accuracy over all wavelengths was similarly improved up to 5x for the hybrid DOI method versus topographic DOI for the deepest inclusions. |
| first_indexed | 2024-04-12T04:33:25Z |
| format | Article |
| id | doaj.art-616c0398dc614569b1fa99c00fe69dfd |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-04-12T04:33:25Z |
| publishDate | 2020-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-616c0398dc614569b1fa99c00fe69dfd2022-12-22T03:47:53ZengMDPI AGApplied Sciences2076-34172020-02-01104141910.3390/app10041419app10041419Method for Quantitative Broadband Diffuse Optical Spectroscopy of Tumor-Like InclusionsSandhya Vasudevan0Farnoush Forghani1Chris Campbell2Savannah Bedford3Thomas D. O’Sullivan4Department of Electrical Engineering, University of Notre Dame, Notre Dame, IN 46556, USADepartment of Radiation Oncology, University of Colorado, School of Medicine, Aurora, CO 80045, USADepartment of Electrical Engineering, University of Notre Dame, Notre Dame, IN 46556, USADepartment of Electrical Engineering, University of Notre Dame, Notre Dame, IN 46556, USADepartment of Electrical Engineering, University of Notre Dame, Notre Dame, IN 46556, USAA hybrid reflectance-based diffuse optical imaging (DOI) technique combining discrete wavelength frequency-domain (FD) near-infrared spectroscopy (NIRS) with broadband continuous wave NIRS measurements was developed to quantify the broadband optical properties of deep tumor-like inclusions. This method was developed to more accurately measure the broadband optical properties of human tumors using a compact handheld imaging probe and without requiring a priori spectral constraints. We simulated the reconstruction of absorption and scattering spectra (650−1000 nm) of human breast tumors in a homogeneous background at depths of 0 to 10 mm. The hybrid DOI technique demonstrated enhanced performance in reconstruction of optical absorption with a mean accuracy over all 71 wavelengths of 8.39% versus 32.26% for a 10 mm deep tumor with the topographic DOI method. The new hybrid technique was also tested and validated on two heterogeneous tissue-simulating phantoms with inclusion depths of 2, 7, and 9 mm. The mean optical absorption accuracy over all wavelengths was similarly improved up to 5x for the hybrid DOI method versus topographic DOI for the deepest inclusions.https://www.mdpi.com/2076-3417/10/4/1419diffuse optical spectroscopyhyperspectral diffuse optical imaginghybrid frequency-domain (fd) continuous-wave (cw) methoddiffuse optical imagingmultispectral imagingbroadband imaging |
| spellingShingle | Sandhya Vasudevan Farnoush Forghani Chris Campbell Savannah Bedford Thomas D. O’Sullivan Method for Quantitative Broadband Diffuse Optical Spectroscopy of Tumor-Like Inclusions Applied Sciences diffuse optical spectroscopy hyperspectral diffuse optical imaging hybrid frequency-domain (fd) continuous-wave (cw) method diffuse optical imaging multispectral imaging broadband imaging |
| title | Method for Quantitative Broadband Diffuse Optical Spectroscopy of Tumor-Like Inclusions |
| title_full | Method for Quantitative Broadband Diffuse Optical Spectroscopy of Tumor-Like Inclusions |
| title_fullStr | Method for Quantitative Broadband Diffuse Optical Spectroscopy of Tumor-Like Inclusions |
| title_full_unstemmed | Method for Quantitative Broadband Diffuse Optical Spectroscopy of Tumor-Like Inclusions |
| title_short | Method for Quantitative Broadband Diffuse Optical Spectroscopy of Tumor-Like Inclusions |
| title_sort | method for quantitative broadband diffuse optical spectroscopy of tumor like inclusions |
| topic | diffuse optical spectroscopy hyperspectral diffuse optical imaging hybrid frequency-domain (fd) continuous-wave (cw) method diffuse optical imaging multispectral imaging broadband imaging |
| url | https://www.mdpi.com/2076-3417/10/4/1419 |
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