The Distribution of Hepatitis C Virus (HCV) Genotypes in 59 HCV Infected Patients: A Multicenter Study
Eighty anti-HCV positive serum samples were collected at university centers in Malatya, Erzurum, Samsun and Konya. HCV-RNA sequences were detected in 59 (73.3%) of these samples by reverse transcriptase-polymerase chain reaction (RT-PCR) using primers from the 5’ non-coding region. HCV-RNA positive...
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| Format: | Article |
| Language: | English |
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Bilimsel Tip Yayinevi
1996-06-01
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| Series: | Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi |
| Subjects: | |
| Online Access: | http://www.floradergisi.org/getFileContent.aspx?op=REDPDF&file_name=1996-1-2-092-095.pdf |
| _version_ | 1797923610469335040 |
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| author | Emine SÖNMEZ Mehmet A. TAŞYARAN Nedim KIZILKAYA Hilal KORKUT Zeki TOMBUL Zeynep C. AKÇAM Şerafettin YILMAZ Fatih KÖKSAL Hakan LEBLEBİCİOĞLU Hamdi EKİCİ |
| author_facet | Emine SÖNMEZ Mehmet A. TAŞYARAN Nedim KIZILKAYA Hilal KORKUT Zeki TOMBUL Zeynep C. AKÇAM Şerafettin YILMAZ Fatih KÖKSAL Hakan LEBLEBİCİOĞLU Hamdi EKİCİ |
| author_sort | Emine SÖNMEZ |
| collection | DOAJ |
| description | Eighty anti-HCV positive serum samples were collected at university centers in Malatya, Erzurum, Samsun and Konya. HCV-RNA sequences were detected in 59 (73.3%) of these samples by reverse transcriptase-polymerase chain reaction (RT-PCR) using primers from the 5’ non-coding region. HCV-RNA positive samples were subsequently genotyped using type-specific primers from the core region of the virus. Type II (I b) infection was detected in 41 samples (69.5%), while a mix type I (I a) and II (I b) infection were found in another 3 samples (5.1%). The remaining 15 samples (25.4%) could have not been typed. These results together with the results of previous studies suggest the predominance of genotype II infection in Turkish patients which is known to have poorer prognosis and lower responce to interferon treatment. |
| first_indexed | 2024-04-10T14:50:11Z |
| format | Article |
| id | doaj.art-616c7c83b8cc43c090ed7294193fc547 |
| institution | Directory Open Access Journal |
| issn | 1300-932X 1300-932X |
| language | English |
| last_indexed | 2024-04-10T14:50:11Z |
| publishDate | 1996-06-01 |
| publisher | Bilimsel Tip Yayinevi |
| record_format | Article |
| series | Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi |
| spelling | doaj.art-616c7c83b8cc43c090ed7294193fc5472023-02-15T16:07:39ZengBilimsel Tip YayineviFlora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi1300-932X1300-932X1996-06-01129295The Distribution of Hepatitis C Virus (HCV) Genotypes in 59 HCV Infected Patients: A Multicenter StudyEmine SÖNMEZ0Mehmet A. TAŞYARAN1Nedim KIZILKAYA2Hilal KORKUT3Zeki TOMBUL4Zeynep C. AKÇAM5Şerafettin YILMAZ6Fatih KÖKSAL7Hakan LEBLEBİCİOĞLU8Hamdi EKİCİ9İnönü Üniversitesi Tıp Fakültesi, Klinik Bakteriyoloji ve İnfeksiyon Hastalıkları Anabilim Dalı, MALATYAAtatürk Üniversitesi Tıp Fakültesi, Klinik Bakteriyoloji ve İnfeksiyon Hastalıkları Anabilim Dalı, ERZURUMİnönü Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, MALATYAÇukurova Üniversitesi Tıp Fakültesi, Mikrobiyoloji Anabilim Dalı, ADANAAtatürk Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, ERZURUMOndokuz Mayıs Üniversitesi Tıp Fakültesi, Klinik Bakteriyoloji ve İnfeksiyon Hastalıkları Anabilim Dalı, SAMSUNAtatürk Üniversitesi Tıp Fakültesi, Klinik Bakteriyoloji ve İnfeksiyon Hastalıkları Anabilim Dalı, ERZURUMÇukurova Üniversitesi Tıp Fakültesi, Mikrobiyoloji Anabilim Dalı, ADANAOndokuz Mayıs Üniversitesi Tıp Fakültesi, Klinik Bakteriyoloji ve İnfeksiyon Hastalıkları Anabilim Dalı, SAMSUNSelçuk Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, KONYAEighty anti-HCV positive serum samples were collected at university centers in Malatya, Erzurum, Samsun and Konya. HCV-RNA sequences were detected in 59 (73.3%) of these samples by reverse transcriptase-polymerase chain reaction (RT-PCR) using primers from the 5’ non-coding region. HCV-RNA positive samples were subsequently genotyped using type-specific primers from the core region of the virus. Type II (I b) infection was detected in 41 samples (69.5%), while a mix type I (I a) and II (I b) infection were found in another 3 samples (5.1%). The remaining 15 samples (25.4%) could have not been typed. These results together with the results of previous studies suggest the predominance of genotype II infection in Turkish patients which is known to have poorer prognosis and lower responce to interferon treatment.http://www.floradergisi.org/getFileContent.aspx?op=REDPDF&file_name=1996-1-2-092-095.pdfHCV GenotypesHCV-RNATurkey |
| spellingShingle | Emine SÖNMEZ Mehmet A. TAŞYARAN Nedim KIZILKAYA Hilal KORKUT Zeki TOMBUL Zeynep C. AKÇAM Şerafettin YILMAZ Fatih KÖKSAL Hakan LEBLEBİCİOĞLU Hamdi EKİCİ The Distribution of Hepatitis C Virus (HCV) Genotypes in 59 HCV Infected Patients: A Multicenter Study Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi HCV Genotypes HCV-RNA Turkey |
| title | The Distribution of Hepatitis C Virus (HCV) Genotypes in 59 HCV Infected Patients: A Multicenter Study |
| title_full | The Distribution of Hepatitis C Virus (HCV) Genotypes in 59 HCV Infected Patients: A Multicenter Study |
| title_fullStr | The Distribution of Hepatitis C Virus (HCV) Genotypes in 59 HCV Infected Patients: A Multicenter Study |
| title_full_unstemmed | The Distribution of Hepatitis C Virus (HCV) Genotypes in 59 HCV Infected Patients: A Multicenter Study |
| title_short | The Distribution of Hepatitis C Virus (HCV) Genotypes in 59 HCV Infected Patients: A Multicenter Study |
| title_sort | distribution of hepatitis c virus hcv genotypes in 59 hcv infected patients a multicenter study |
| topic | HCV Genotypes HCV-RNA Turkey |
| url | http://www.floradergisi.org/getFileContent.aspx?op=REDPDF&file_name=1996-1-2-092-095.pdf |
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