A case of germinoma located in the fornix inducing transsynaptic atrophy of the Papez circuit
Germinoma is a rare CNS germ cell tumor preferentially affecting children and young adults. Intracranial germinomas arise typically in the neurohypophysis and pineal region and occasionally in the basal ganglia and thalamus. Germinomas in the basal ganglia and thalamus are characterized by the ipsil...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Radiology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S193004332200944X |
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| author | Shintaro Kano, MD, PhD Mitsuru Matsuki, MD, PhD Rieko Furukawa, MD, PhD Waka Nakata, MD, PhD Hirofumi Oguma, MD, PhD Akira Gomi, MD, PhD Harushi Mori, MD, PhD |
| author_facet | Shintaro Kano, MD, PhD Mitsuru Matsuki, MD, PhD Rieko Furukawa, MD, PhD Waka Nakata, MD, PhD Hirofumi Oguma, MD, PhD Akira Gomi, MD, PhD Harushi Mori, MD, PhD |
| author_sort | Shintaro Kano, MD, PhD |
| collection | DOAJ |
| description | Germinoma is a rare CNS germ cell tumor preferentially affecting children and young adults. Intracranial germinomas arise typically in the neurohypophysis and pineal region and occasionally in the basal ganglia and thalamus. Germinomas in the basal ganglia and thalamus are characterized by the ipsilateral cerebral and brainstem hemiatrophy with slowly progressive neurological deficits, which is due to tumor infiltration into the thalamocortical and corticospinal tract and induction of anterograde and retrograde Wallerian degeneration. We report an 11-year-old boy with a mass located in the fornix incidentally discovered on the first work-up of his minor head injury. Imaging findings revealed the ipsilateral atrophy of the mammillary body and the fornix. Stereotactic brain biopsy was performed and the final diagnosis was germinoma. The ipsilateral atrophy of the mammillary body and the fornix implied the transsynaptic degeneration via the Papez circuit. We discuss the unique nature of germinomas and underlying pathological mechanisms. |
| first_indexed | 2024-04-11T06:36:05Z |
| format | Article |
| id | doaj.art-616f6275235c4ed58c9dda029ffffc62 |
| institution | Directory Open Access Journal |
| issn | 1930-0433 |
| language | English |
| last_indexed | 2024-04-11T06:36:05Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiology Case Reports |
| spelling | doaj.art-616f6275235c4ed58c9dda029ffffc622022-12-22T04:39:41ZengElsevierRadiology Case Reports1930-04332023-01-01181405409A case of germinoma located in the fornix inducing transsynaptic atrophy of the Papez circuitShintaro Kano, MD, PhD0Mitsuru Matsuki, MD, PhD1Rieko Furukawa, MD, PhD2Waka Nakata, MD, PhD3Hirofumi Oguma, MD, PhD4Akira Gomi, MD, PhD5Harushi Mori, MD, PhD6Department of Radiology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi-ken, 329-049, Japan; Corresponding author.Department of Radiology, Jichi Children's Medical Center Tochigi, Shimotsuke-shi, JapanDepartment of Radiology, Jichi Children's Medical Center Tochigi, Shimotsuke-shi, JapanDepartment of Radiology, Jichi Children's Medical Center Tochigi, Shimotsuke-shi, JapanDepartment of Neurosurgery, Jichi Medical University, Shimotsuke-shi, JapanDepartment of Neurosurgery, Jichi Medical University, Shimotsuke-shi, JapanDepartment of Radiology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi-ken, 329-049, JapanGerminoma is a rare CNS germ cell tumor preferentially affecting children and young adults. Intracranial germinomas arise typically in the neurohypophysis and pineal region and occasionally in the basal ganglia and thalamus. Germinomas in the basal ganglia and thalamus are characterized by the ipsilateral cerebral and brainstem hemiatrophy with slowly progressive neurological deficits, which is due to tumor infiltration into the thalamocortical and corticospinal tract and induction of anterograde and retrograde Wallerian degeneration. We report an 11-year-old boy with a mass located in the fornix incidentally discovered on the first work-up of his minor head injury. Imaging findings revealed the ipsilateral atrophy of the mammillary body and the fornix. Stereotactic brain biopsy was performed and the final diagnosis was germinoma. The ipsilateral atrophy of the mammillary body and the fornix implied the transsynaptic degeneration via the Papez circuit. We discuss the unique nature of germinomas and underlying pathological mechanisms.http://www.sciencedirect.com/science/article/pii/S193004332200944XGerminomaFornixMamillary bodyPapez circuitAtrophy |
| spellingShingle | Shintaro Kano, MD, PhD Mitsuru Matsuki, MD, PhD Rieko Furukawa, MD, PhD Waka Nakata, MD, PhD Hirofumi Oguma, MD, PhD Akira Gomi, MD, PhD Harushi Mori, MD, PhD A case of germinoma located in the fornix inducing transsynaptic atrophy of the Papez circuit Radiology Case Reports Germinoma Fornix Mamillary body Papez circuit Atrophy |
| title | A case of germinoma located in the fornix inducing transsynaptic atrophy of the Papez circuit |
| title_full | A case of germinoma located in the fornix inducing transsynaptic atrophy of the Papez circuit |
| title_fullStr | A case of germinoma located in the fornix inducing transsynaptic atrophy of the Papez circuit |
| title_full_unstemmed | A case of germinoma located in the fornix inducing transsynaptic atrophy of the Papez circuit |
| title_short | A case of germinoma located in the fornix inducing transsynaptic atrophy of the Papez circuit |
| title_sort | case of germinoma located in the fornix inducing transsynaptic atrophy of the papez circuit |
| topic | Germinoma Fornix Mamillary body Papez circuit Atrophy |
| url | http://www.sciencedirect.com/science/article/pii/S193004332200944X |
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