Generalizable Compositional Features Influencing the Proteostatic Fates of Polar Low-Complexity Domains

Generalizable Compositional Features Influencing the Proteostatic Fates of Polar Low-Complexity Domains

Protein aggregation is associated with a growing list of human diseases. A substantial fraction of proteins in eukaryotic proteomes constitutes a proteostasis network—a collection of proteins that work together to maintain properly folded proteins. One of the overarching functions of the proteostasi...

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Bibliographic Details
Main Authors: Sean M. Cascarina, Joshua P. Kaplan, Mikaela R. Elder, Lindsey Brookbank, Eric D. Ross
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
proteostasis
protein aggregation
prion
protein degradation
amyloid
ubiquitin-proteasome system
Online Access:https://www.mdpi.com/1422-0067/22/16/8944

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