A study on changes of the resting-state brain function network in patients with amnestic mild cognitive impairment
This study aimed to explore the structural and functional characteristics of the neural network of resting-state brain activities in patients with amnestic mild cognitive impairment (aMCI) by functional magnetic resonance imaging (fMRI) technology. Resting state fMRI scanning was performed on 10 cli...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2019-04-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000500607&lng=en&tlng=en |
| _version_ | 1819211417258033152 |
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| author | Jun Min Xu-Xin Zhou Feng Zhou Yu Tan Wei-Dong Wang |
| author_facet | Jun Min Xu-Xin Zhou Feng Zhou Yu Tan Wei-Dong Wang |
| author_sort | Jun Min |
| collection | DOAJ |
| description | This study aimed to explore the structural and functional characteristics of the neural network of resting-state brain activities in patients with amnestic mild cognitive impairment (aMCI) by functional magnetic resonance imaging (fMRI) technology. Resting state fMRI scanning was performed on 10 clinically diagnosed aMCI patients and 10 healthy volunteers, and the difference in the resting-state brain activities between aMCI patients and healthy volunteers was compared using the brain function network regional homogeneity (ReHo) analysis method. Results of the ReHo analysis of aMCI patients and healthy volunteers revealed that the ReHo value significantly increased in the posterior cingulate gyrus region, medial frontal lobe, medial cortex of the prefrontal lobe, and part of the parietal lobe. Compared with the normal elderlies, ReHo decreased in aMCI patients in the left temporal lobe (middle temporal gyrus and inferior temporal gyrus), left parahippocampal gyrus, occipital lobe, lingual gyrus, precuneus, and other regions while ReHo increased in regions of the right frontal lobe (inferior frontal gyrus), left superior temporal gyrus, precentral gyrus (frontal lobe), right thalamus, left fusiform gyrus, and other regions. In the resting state, there may be regional abnormalities in brain functional areas in aMCI patients, which may be associated with cognitive impairment. |
| first_indexed | 2024-12-23T06:26:44Z |
| format | Article |
| id | doaj.art-617046abeb9046a586ed5e78a5809e74 |
| institution | Directory Open Access Journal |
| issn | 1414-431X |
| language | English |
| last_indexed | 2024-12-23T06:26:44Z |
| publishDate | 2019-04-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-617046abeb9046a586ed5e78a5809e742022-12-21T17:57:02ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research1414-431X2019-04-0152510.1590/1414-431x20198244S0100-879X2019000500607A study on changes of the resting-state brain function network in patients with amnestic mild cognitive impairmentJun MinXu-Xin ZhouFeng ZhouYu TanWei-Dong WangThis study aimed to explore the structural and functional characteristics of the neural network of resting-state brain activities in patients with amnestic mild cognitive impairment (aMCI) by functional magnetic resonance imaging (fMRI) technology. Resting state fMRI scanning was performed on 10 clinically diagnosed aMCI patients and 10 healthy volunteers, and the difference in the resting-state brain activities between aMCI patients and healthy volunteers was compared using the brain function network regional homogeneity (ReHo) analysis method. Results of the ReHo analysis of aMCI patients and healthy volunteers revealed that the ReHo value significantly increased in the posterior cingulate gyrus region, medial frontal lobe, medial cortex of the prefrontal lobe, and part of the parietal lobe. Compared with the normal elderlies, ReHo decreased in aMCI patients in the left temporal lobe (middle temporal gyrus and inferior temporal gyrus), left parahippocampal gyrus, occipital lobe, lingual gyrus, precuneus, and other regions while ReHo increased in regions of the right frontal lobe (inferior frontal gyrus), left superior temporal gyrus, precentral gyrus (frontal lobe), right thalamus, left fusiform gyrus, and other regions. In the resting state, there may be regional abnormalities in brain functional areas in aMCI patients, which may be associated with cognitive impairment.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000500607&lng=en&tlng=enAmnesticMild cognitive impairmentFunction networkResting stateFunctional magnetic resonance imaging |
| spellingShingle | Jun Min Xu-Xin Zhou Feng Zhou Yu Tan Wei-Dong Wang A study on changes of the resting-state brain function network in patients with amnestic mild cognitive impairment Brazilian Journal of Medical and Biological Research Amnestic Mild cognitive impairment Function network Resting state Functional magnetic resonance imaging |
| title | A study on changes of the resting-state brain function network in patients with amnestic mild cognitive impairment |
| title_full | A study on changes of the resting-state brain function network in patients with amnestic mild cognitive impairment |
| title_fullStr | A study on changes of the resting-state brain function network in patients with amnestic mild cognitive impairment |
| title_full_unstemmed | A study on changes of the resting-state brain function network in patients with amnestic mild cognitive impairment |
| title_short | A study on changes of the resting-state brain function network in patients with amnestic mild cognitive impairment |
| title_sort | study on changes of the resting state brain function network in patients with amnestic mild cognitive impairment |
| topic | Amnestic Mild cognitive impairment Function network Resting state Functional magnetic resonance imaging |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000500607&lng=en&tlng=en |
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