Phenotype of Coats disease in females
Objective To determine whether the clinical presentation of Coats disease differs between males and females.Methods and analysis Records of patients diagnosed with Coats disease at a single institution were retrospectively reviewed. Demographic data, main reason for initial consultation, comprehensi...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2022-10-01
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| Series: | BMJ Open Ophthalmology |
| Online Access: | https://bmjophth.bmj.com/content/7/1/e000883.full |
| _version_ | 1797778438179782656 |
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| author | Alejandra Daruich Francis L Munier |
| author_facet | Alejandra Daruich Francis L Munier |
| author_sort | Alejandra Daruich |
| collection | DOAJ |
| description | Objective To determine whether the clinical presentation of Coats disease differs between males and females.Methods and analysis Records of patients diagnosed with Coats disease at a single institution were retrospectively reviewed. Demographic data, main reason for initial consultation, comprehensive ocular examination at diagnosis and modalities of treatments during the follow-up were recorded.Results Records from 114 patients with Coats disease were analysed. Ninety-eight patients (86%) were male and 16 (14%) female. Mean age at diagnosis was 6.2 years±6.1 in males and 7.4 years±4.7 in females. The main initial reason for consultation was strabismus in males and decreased visual acuity in females. Stage severity at diagnosis was similar in the two groups with half of the patients presenting with stage 2B2 or lower. The extension of peripheral retinal telangiectasia was also similar (mean: 6.2±3.4 and 5.8±4.0, respectively), as was the extension of intraretinal exudation (mean: 5.0±4.5 and 5.8±4.4) and the frequency of a subfoveal nodule at diagnosis (40% vs 30%, respectively). There was no distinction between the number of laser photocoagulation or cryotherapy sessions required for both groups during the follow-up.Conclusions Coats disease presentation does not differ between genders despite being much rarer in females. We propose a pathogenic mechanism accounting for the gender-dependent incidence combined with gender-independent expressivity of Coats disease. |
| first_indexed | 2024-03-12T23:17:22Z |
| format | Article |
| id | doaj.art-6170cb4663bc49419f13f4f9ce7ad11e |
| institution | Directory Open Access Journal |
| issn | 2397-3269 |
| language | English |
| last_indexed | 2024-03-12T23:17:22Z |
| publishDate | 2022-10-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Ophthalmology |
| spelling | doaj.art-6170cb4663bc49419f13f4f9ce7ad11e2023-07-17T00:00:06ZengBMJ Publishing GroupBMJ Open Ophthalmology2397-32692022-10-017110.1136/bmjophth-2021-000883Phenotype of Coats disease in femalesAlejandra Daruich0Francis L Munier1Ophthalmology Department, Hôpital Necker-Enfants Malades, AP-HP, Université de Paris, Paris. INSERM, Centre de Recherche des Cordeliers, Team 17, Paris, FranceJules-Gonin Eye Hospital, Fondation Asile des Aveugles, University of Lausanne, Lausanne, SwitzerlandObjective To determine whether the clinical presentation of Coats disease differs between males and females.Methods and analysis Records of patients diagnosed with Coats disease at a single institution were retrospectively reviewed. Demographic data, main reason for initial consultation, comprehensive ocular examination at diagnosis and modalities of treatments during the follow-up were recorded.Results Records from 114 patients with Coats disease were analysed. Ninety-eight patients (86%) were male and 16 (14%) female. Mean age at diagnosis was 6.2 years±6.1 in males and 7.4 years±4.7 in females. The main initial reason for consultation was strabismus in males and decreased visual acuity in females. Stage severity at diagnosis was similar in the two groups with half of the patients presenting with stage 2B2 or lower. The extension of peripheral retinal telangiectasia was also similar (mean: 6.2±3.4 and 5.8±4.0, respectively), as was the extension of intraretinal exudation (mean: 5.0±4.5 and 5.8±4.4) and the frequency of a subfoveal nodule at diagnosis (40% vs 30%, respectively). There was no distinction between the number of laser photocoagulation or cryotherapy sessions required for both groups during the follow-up.Conclusions Coats disease presentation does not differ between genders despite being much rarer in females. We propose a pathogenic mechanism accounting for the gender-dependent incidence combined with gender-independent expressivity of Coats disease.https://bmjophth.bmj.com/content/7/1/e000883.full |
| spellingShingle | Alejandra Daruich Francis L Munier Phenotype of Coats disease in females BMJ Open Ophthalmology |
| title | Phenotype of Coats disease in females |
| title_full | Phenotype of Coats disease in females |
| title_fullStr | Phenotype of Coats disease in females |
| title_full_unstemmed | Phenotype of Coats disease in females |
| title_short | Phenotype of Coats disease in females |
| title_sort | phenotype of coats disease in females |
| url | https://bmjophth.bmj.com/content/7/1/e000883.full |
| work_keys_str_mv | AT alejandradaruich phenotypeofcoatsdiseaseinfemales AT francislmunier phenotypeofcoatsdiseaseinfemales |