A case report of synchronous triple primary malignancies: Diffuse large B-cell lymphoma, rectal adenocarcinoma and hepatocellular carcinoma
A 59-year-old man was admitted to our hospital in August 2020 because of fever with night sweats and weight loss. The patient was eventually diagnosed with synchronous triple primary malignancies: diffuse large B-cell lymphoma (DLBCL), rectal adenocarcinoma and hepatocellular carcinoma (HCC), which...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1046878/full |
| _version_ | 1811290399485984768 |
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| author | Beixuan Qiu Cheng Lin Lupeng Wu Yifei Li |
| author_facet | Beixuan Qiu Cheng Lin Lupeng Wu Yifei Li |
| author_sort | Beixuan Qiu |
| collection | DOAJ |
| description | A 59-year-old man was admitted to our hospital in August 2020 because of fever with night sweats and weight loss. The patient was eventually diagnosed with synchronous triple primary malignancies: diffuse large B-cell lymphoma (DLBCL), rectal adenocarcinoma and hepatocellular carcinoma (HCC), which has not been reported previously. The patient initially received six cycles of R-Gemox chemotherapy targeting DLBCL, the response to the treatment was partial remission. We continued six cycles of R-CHOP therapy, and DLBCL achieved a complete remission to treatment. During R-CHOP chemotherapy, PD-1 inhibitor (Sintilimab) was used to control the disease progression of HCC, which was effective and tolerable. Subsequently, he successfully completed curative intent Dixon operation and right hemihepatectomy. The diagnosis and treatment for like these synchronous triple primary malignancies are a huge challenge, herein we provide our experience in this regard. |
| first_indexed | 2024-04-13T04:12:12Z |
| format | Article |
| id | doaj.art-61726a83751a461bb03229b629b32cd1 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-13T04:12:12Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-61726a83751a461bb03229b629b32cd12022-12-22T03:03:05ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-12-011210.3389/fonc.2022.10468781046878A case report of synchronous triple primary malignancies: Diffuse large B-cell lymphoma, rectal adenocarcinoma and hepatocellular carcinomaBeixuan Qiu0Cheng Lin1Lupeng Wu2Yifei Li3Department of XingLin General Surgery, First Affiliated Hospital of Xiamen University, Xiamen, ChinaDepartment of Hematology, First Affiliated Hospital of Xiamen University, Xiamen, ChinaDepartment of Hepatobiliary & Pancreatovascular Surgery, First Affiliated Hospital of Xiamen University, Xiamen, ChinaDepartment of XingLin General Surgery, First Affiliated Hospital of Xiamen University, Xiamen, ChinaA 59-year-old man was admitted to our hospital in August 2020 because of fever with night sweats and weight loss. The patient was eventually diagnosed with synchronous triple primary malignancies: diffuse large B-cell lymphoma (DLBCL), rectal adenocarcinoma and hepatocellular carcinoma (HCC), which has not been reported previously. The patient initially received six cycles of R-Gemox chemotherapy targeting DLBCL, the response to the treatment was partial remission. We continued six cycles of R-CHOP therapy, and DLBCL achieved a complete remission to treatment. During R-CHOP chemotherapy, PD-1 inhibitor (Sintilimab) was used to control the disease progression of HCC, which was effective and tolerable. Subsequently, he successfully completed curative intent Dixon operation and right hemihepatectomy. The diagnosis and treatment for like these synchronous triple primary malignancies are a huge challenge, herein we provide our experience in this regard.https://www.frontiersin.org/articles/10.3389/fonc.2022.1046878/fullmultiple primary malignanciesdiffuse large B-cell lymphomarectal cancerhepatocellular carcinomadiagnosistreatment |
| spellingShingle | Beixuan Qiu Cheng Lin Lupeng Wu Yifei Li A case report of synchronous triple primary malignancies: Diffuse large B-cell lymphoma, rectal adenocarcinoma and hepatocellular carcinoma Frontiers in Oncology multiple primary malignancies diffuse large B-cell lymphoma rectal cancer hepatocellular carcinoma diagnosis treatment |
| title | A case report of synchronous triple primary malignancies: Diffuse large B-cell lymphoma, rectal adenocarcinoma and hepatocellular carcinoma |
| title_full | A case report of synchronous triple primary malignancies: Diffuse large B-cell lymphoma, rectal adenocarcinoma and hepatocellular carcinoma |
| title_fullStr | A case report of synchronous triple primary malignancies: Diffuse large B-cell lymphoma, rectal adenocarcinoma and hepatocellular carcinoma |
| title_full_unstemmed | A case report of synchronous triple primary malignancies: Diffuse large B-cell lymphoma, rectal adenocarcinoma and hepatocellular carcinoma |
| title_short | A case report of synchronous triple primary malignancies: Diffuse large B-cell lymphoma, rectal adenocarcinoma and hepatocellular carcinoma |
| title_sort | case report of synchronous triple primary malignancies diffuse large b cell lymphoma rectal adenocarcinoma and hepatocellular carcinoma |
| topic | multiple primary malignancies diffuse large B-cell lymphoma rectal cancer hepatocellular carcinoma diagnosis treatment |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1046878/full |
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