A biomaterial with a channel-like pore architecture induces endochondral healing of bone defects

A bioengineering approach to enhance the regeneration of large bone defects is lacking. Here, the authors show that a biomaterial scaffold with a channel-like pore architecture enables organized endochondral ossification through directional cell recruitment and extracellular matrix alignment.

Manylion Llyfryddiaeth
Prif Awduron: A. Petersen, A. Princ, G. Korus, A. Ellinghaus, H. Leemhuis, A. Herrera, A. Klaumünzer, S. Schreivogel, A. Woloszyk, K. Schmidt-Bleek, S. Geissler, I. Heschel, G. N. Duda
Fformat: Erthygl
Iaith:English
Cyhoeddwyd: Nature Portfolio 2018-10-01
Cyfres:Nature Communications
Mynediad Ar-lein:https://doi.org/10.1038/s41467-018-06504-7
Disgrifiad
Crynodeb:A bioengineering approach to enhance the regeneration of large bone defects is lacking. Here, the authors show that a biomaterial scaffold with a channel-like pore architecture enables organized endochondral ossification through directional cell recruitment and extracellular matrix alignment.
ISSN:2041-1723