A biomaterial with a channel-like pore architecture induces endochondral healing of bone defects
A bioengineering approach to enhance the regeneration of large bone defects is lacking. Here, the authors show that a biomaterial scaffold with a channel-like pore architecture enables organized endochondral ossification through directional cell recruitment and extracellular matrix alignment.
| Príomhchruthaitheoirí: | , , , , , , , , , , , , |
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| Formáid: | Alt |
| Teanga: | English |
| Foilsithe / Cruthaithe: |
Nature Portfolio
2018-10-01
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| Sraith: | Nature Communications |
| Rochtain ar líne: | https://doi.org/10.1038/s41467-018-06504-7 |
| _version_ | 1831562606825963520 |
|---|---|
| author | A. Petersen A. Princ G. Korus A. Ellinghaus H. Leemhuis A. Herrera A. Klaumünzer S. Schreivogel A. Woloszyk K. Schmidt-Bleek S. Geissler I. Heschel G. N. Duda |
| author_facet | A. Petersen A. Princ G. Korus A. Ellinghaus H. Leemhuis A. Herrera A. Klaumünzer S. Schreivogel A. Woloszyk K. Schmidt-Bleek S. Geissler I. Heschel G. N. Duda |
| author_sort | A. Petersen |
| collection | DOAJ |
| description | A bioengineering approach to enhance the regeneration of large bone defects is lacking. Here, the authors show that a biomaterial scaffold with a channel-like pore architecture enables organized endochondral ossification through directional cell recruitment and extracellular matrix alignment. |
| first_indexed | 2024-12-17T10:39:50Z |
| format | Article |
| id | doaj.art-6173f1f6a0e44b58b39f4c51d976aca8 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T10:39:50Z |
| publishDate | 2018-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-6173f1f6a0e44b58b39f4c51d976aca82022-12-21T21:52:16ZengNature PortfolioNature Communications2041-17232018-10-019111610.1038/s41467-018-06504-7A biomaterial with a channel-like pore architecture induces endochondral healing of bone defectsA. Petersen0A. Princ1G. Korus2A. Ellinghaus3H. Leemhuis4A. Herrera5A. Klaumünzer6S. Schreivogel7A. Woloszyk8K. Schmidt-Bleek9S. Geissler10I. Heschel11G. N. Duda12Julius Wolff Institute, Charité—Universitätsmedizin BerlinJulius Wolff Institute, Charité—Universitätsmedizin BerlinJulius Wolff Institute, Charité—Universitätsmedizin BerlinJulius Wolff Institute, Charité—Universitätsmedizin BerlinMatricel GmbHJulius Wolff Institute, Charité—Universitätsmedizin BerlinJulius Wolff Institute, Charité—Universitätsmedizin BerlinJulius Wolff Institute, Charité—Universitätsmedizin BerlinJulius Wolff Institute, Charité—Universitätsmedizin BerlinJulius Wolff Institute, Charité—Universitätsmedizin BerlinJulius Wolff Institute, Charité—Universitätsmedizin BerlinMatricel GmbHJulius Wolff Institute, Charité—Universitätsmedizin BerlinA bioengineering approach to enhance the regeneration of large bone defects is lacking. Here, the authors show that a biomaterial scaffold with a channel-like pore architecture enables organized endochondral ossification through directional cell recruitment and extracellular matrix alignment.https://doi.org/10.1038/s41467-018-06504-7 |
| spellingShingle | A. Petersen A. Princ G. Korus A. Ellinghaus H. Leemhuis A. Herrera A. Klaumünzer S. Schreivogel A. Woloszyk K. Schmidt-Bleek S. Geissler I. Heschel G. N. Duda A biomaterial with a channel-like pore architecture induces endochondral healing of bone defects Nature Communications |
| title | A biomaterial with a channel-like pore architecture induces endochondral healing of bone defects |
| title_full | A biomaterial with a channel-like pore architecture induces endochondral healing of bone defects |
| title_fullStr | A biomaterial with a channel-like pore architecture induces endochondral healing of bone defects |
| title_full_unstemmed | A biomaterial with a channel-like pore architecture induces endochondral healing of bone defects |
| title_short | A biomaterial with a channel-like pore architecture induces endochondral healing of bone defects |
| title_sort | biomaterial with a channel like pore architecture induces endochondral healing of bone defects |
| url | https://doi.org/10.1038/s41467-018-06504-7 |
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