Multiple isolates from Aids patients: aspects of an analysis by a genotypic marker and antimicrobial susceptibilities variations
Twenty-one Mycobacterium avium multisolates, from ten human immunodeficiency virus-infected patients, were typed by restriction fragment length polymorphism using as marker the IS1245 and characterized by minimum inhibitory concentration for nine different antibiotics. Two out of four patients harbo...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Fundação Oswaldo Cruz (FIOCRUZ)
2000-10-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762000000500021 |
| _version_ | 1827833078294249472 |
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| author | Maria Helena Féres Saad Maria Alice Telles Fátima Porfirio Lucilaine Ferrazoli Leila de Souza Fonseca Warren Johnson Jr Lee W Riley |
| author_facet | Maria Helena Féres Saad Maria Alice Telles Fátima Porfirio Lucilaine Ferrazoli Leila de Souza Fonseca Warren Johnson Jr Lee W Riley |
| author_sort | Maria Helena Féres Saad |
| collection | DOAJ |
| description | Twenty-one Mycobacterium avium multisolates, from ten human immunodeficiency virus-infected patients, were typed by restriction fragment length polymorphism using as marker the IS1245 and characterized by minimum inhibitory concentration for nine different antibiotics. Two out of four patients harboring multisolates with different fingerprint profile, were therefore considered as having a polyclonal infection, since their isolates were taken from sterile site. This result confirms that polyclonal infection caused by M. avium occurs with a nonnegligenciable frequency. Analyzing the multisolates susceptibility profile of each patient it was observed that most of them were infected with strains having appreciably different antimicrobial susceptibility patterns, no matter what the genotypic pattern of the strains was. These results have strong implication for the treatment of the patients. |
| first_indexed | 2024-03-12T05:23:43Z |
| format | Article |
| id | doaj.art-6175413c636d403d8ff5f8555921901f |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T05:23:43Z |
| publishDate | 2000-10-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-6175413c636d403d8ff5f8555921901f2023-09-03T07:27:13ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602000-10-0195572973210.1590/S0074-02762000000500021Multiple isolates from Aids patients: aspects of an analysis by a genotypic marker and antimicrobial susceptibilities variationsMaria Helena Féres SaadMaria Alice TellesFátima PorfirioLucilaine FerrazoliLeila de Souza FonsecaWarren Johnson JrLee W RileyTwenty-one Mycobacterium avium multisolates, from ten human immunodeficiency virus-infected patients, were typed by restriction fragment length polymorphism using as marker the IS1245 and characterized by minimum inhibitory concentration for nine different antibiotics. Two out of four patients harboring multisolates with different fingerprint profile, were therefore considered as having a polyclonal infection, since their isolates were taken from sterile site. This result confirms that polyclonal infection caused by M. avium occurs with a nonnegligenciable frequency. Analyzing the multisolates susceptibility profile of each patient it was observed that most of them were infected with strains having appreciably different antimicrobial susceptibility patterns, no matter what the genotypic pattern of the strains was. These results have strong implication for the treatment of the patients.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762000000500021Mycobacterium aviumpolyclonal infectionsusceptibility test |
| spellingShingle | Maria Helena Féres Saad Maria Alice Telles Fátima Porfirio Lucilaine Ferrazoli Leila de Souza Fonseca Warren Johnson Jr Lee W Riley Multiple isolates from Aids patients: aspects of an analysis by a genotypic marker and antimicrobial susceptibilities variations Memorias do Instituto Oswaldo Cruz Mycobacterium avium polyclonal infection susceptibility test |
| title | Multiple isolates from Aids patients: aspects of an analysis by a genotypic marker and antimicrobial susceptibilities variations |
| title_full | Multiple isolates from Aids patients: aspects of an analysis by a genotypic marker and antimicrobial susceptibilities variations |
| title_fullStr | Multiple isolates from Aids patients: aspects of an analysis by a genotypic marker and antimicrobial susceptibilities variations |
| title_full_unstemmed | Multiple isolates from Aids patients: aspects of an analysis by a genotypic marker and antimicrobial susceptibilities variations |
| title_short | Multiple isolates from Aids patients: aspects of an analysis by a genotypic marker and antimicrobial susceptibilities variations |
| title_sort | multiple isolates from aids patients aspects of an analysis by a genotypic marker and antimicrobial susceptibilities variations |
| topic | Mycobacterium avium polyclonal infection susceptibility test |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762000000500021 |
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