EHBP1L1 Drives Immune Evasion in Renal Cell Carcinoma through Binding and Stabilizing JAK1

EHBP1L1 Drives Immune Evasion in Renal Cell Carcinoma through Binding and Stabilizing JAK1

Abstract High lymphocyte infiltration and immunosuppression characterize the tumor microenvironment (TME) in renal cell carcinoma (RCC). There is an urgent need to elucidate how tumor cells escape the immune attack and to develop novel therapeutic targets to enhance the efficacy of immune checkpoint...

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Bibliographic Details
Main Authors: Yihui Pan, Guannan Shu, Liangmin Fu, Kangbo Huang, Xinwei Zhou, Chengpeng Gui, Huashan Liu, Xiaohan Jin, Minyu Chen, Pengju Li, Junjie Cen, Zihao Feng, Jun Lu, Zhenhua Chen, Jiaying Li, Quanhui Xu, Yinghan Wang, Hui Liang, Zhu Wang, Qiong Deng, Wei Chen, Junhang Luo, Jiefeng Yang, Jiaxing Zhang, Jinhuan Wei
Format: Article
Language:English
Published: Wiley 2023-04-01
Series:Advanced Science
Subjects:
EHBP1L1
IFN‐γ/JAK1/STAT1/PD‐L1 signaling
immune evasion
renal cell carcinoma
Online Access:https://doi.org/10.1002/advs.202206792

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