Penurunan Imunoekspresi P63 Pada Mioepitel Ductal Carcinoma In Situ (DCIS) Payudara Sebagai Prediktor Infiltrasi Tumor
The occurrence of breast carcinoma is common in women. Ductal carcinoma in situ (DCIS) of the breast is breast carcinoma with tumor cells which exist in the breast glandular duct and have not infiltrated into stroma. Retrospective study has been made on 23 paraffin blocks of morphological breast DCI...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Universitas Padjajaran
2009-03-01
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| Series: | Majalah Kedokteran Bandung |
| Subjects: | |
| Online Access: | http://journal.fk.unpad.ac.id/index.php/mkb/article/view/259 |
| Summary: | The occurrence of breast carcinoma is common in women. Ductal carcinoma in situ (DCIS) of the breast is breast carcinoma with tumor cells which exist in the breast glandular duct and have not infiltrated into stroma. Retrospective study has been made on 23 paraffin blocks of morphological breast DCIS variants, namely kribriform, solid, and komedo. One way to find out DCIS aggressiveness is by detecting myoepithelial cells surrounding the breast duct indicating the integrity of the basal membrane. Detection of myoepithelial cells by means of immunohistochemical technique is done by using a selective marker for breast myoepithelial cells, namely p63. The aim of this research was predict tumor infiltration through decrease of immunoexpression of p63 in myoepithelial cells of morphological variants: cibriform, solid, and komedo of breast DCIS. This research was performed at Pathology Anatomy Laboratory of Medical Faculty of Padjadjaran University/RSUP Hasan Sadikin Bandung from Juli 2005 to September 2006. The result of the research indicated that immunoexpression of p63 in myoepithelial cells of morphological breast DCIS variants - cibriform, solid and komedo - did not show any significant difference (p<: 0,05). This indicated that tumor infiltration can occur in every breast DCIS morphological variant being studied, namely cribriform, solid, and comedo. The conclusion of this research is that decrease of immunoexpression of p63 in myoepithelial cells of morphological variants: cibriform, solid, and comedo of breast DCIS predict the presence of tumor infiltration. |
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| ISSN: | 0126-074X 2338-6223 |