The landscape of lncRNAs in gastric cancer: from molecular mechanisms to potential clinical applications
Gastric cancer (GC) is a highly prevalent and deadly malignant neoplasm worldwide. Currently, long non-coding RNAs (lncRNAs) have recently been identified as crucial regulators implicated in GC development and progression. Dysregulated expression of lncRNAs is commonly associated with enhanced tumor...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1237723/full |
| _version_ | 1797740102185648128 |
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| author | Jéssica Manoelli Costa Silva Eliel Barbosa Teixeira Ronald Matheus da Silva Mourão Rafaella Sousa Ferraz Fabiano Cordeiro Moreira Paulo Pimentel de Assumpção Danielle Queiroz Calcagno |
| author_facet | Jéssica Manoelli Costa Silva Eliel Barbosa Teixeira Ronald Matheus da Silva Mourão Rafaella Sousa Ferraz Fabiano Cordeiro Moreira Paulo Pimentel de Assumpção Danielle Queiroz Calcagno |
| author_sort | Jéssica Manoelli Costa Silva |
| collection | DOAJ |
| description | Gastric cancer (GC) is a highly prevalent and deadly malignant neoplasm worldwide. Currently, long non-coding RNAs (lncRNAs) have recently been identified as crucial regulators implicated in GC development and progression. Dysregulated expression of lncRNAs is commonly associated with enhanced tumor migration, invasiveness, and therapy resistance, highlighting their potential as promising targets for clinical applications. This review offers a comprehensive historical overview of lncRNAs in GC, describes the molecular mechanisms, and discusses the prospects and challenges of establishing lncRNAs as precision biomarkers. |
| first_indexed | 2024-03-12T14:07:42Z |
| format | Article |
| id | doaj.art-617a7f59a467415dbd58028a4a112aa5 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-12T14:07:42Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-617a7f59a467415dbd58028a4a112aa52023-08-21T13:54:42ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-08-011410.3389/fphar.2023.12377231237723The landscape of lncRNAs in gastric cancer: from molecular mechanisms to potential clinical applicationsJéssica Manoelli Costa Silva0Eliel Barbosa Teixeira1Ronald Matheus da Silva Mourão2Rafaella Sousa Ferraz3Fabiano Cordeiro Moreira4Paulo Pimentel de Assumpção5Danielle Queiroz Calcagno6Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belem, Pará, BrazilNúcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belem, Pará, BrazilNúcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belem, Pará, BrazilLaboratório de Genética Humana e Médica, Universidade Federal do Pará, Belem, Pará, BrazilNúcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belem, Pará, BrazilNúcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belem, Pará, BrazilNúcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belem, Pará, BrazilGastric cancer (GC) is a highly prevalent and deadly malignant neoplasm worldwide. Currently, long non-coding RNAs (lncRNAs) have recently been identified as crucial regulators implicated in GC development and progression. Dysregulated expression of lncRNAs is commonly associated with enhanced tumor migration, invasiveness, and therapy resistance, highlighting their potential as promising targets for clinical applications. This review offers a comprehensive historical overview of lncRNAs in GC, describes the molecular mechanisms, and discusses the prospects and challenges of establishing lncRNAs as precision biomarkers.https://www.frontiersin.org/articles/10.3389/fphar.2023.1237723/fulllong non-coding RNAsgastric cancergastric carcinogenesishistorical overviewmolecular mechanismsbiomarkers |
| spellingShingle | Jéssica Manoelli Costa Silva Eliel Barbosa Teixeira Ronald Matheus da Silva Mourão Rafaella Sousa Ferraz Fabiano Cordeiro Moreira Paulo Pimentel de Assumpção Danielle Queiroz Calcagno The landscape of lncRNAs in gastric cancer: from molecular mechanisms to potential clinical applications Frontiers in Pharmacology long non-coding RNAs gastric cancer gastric carcinogenesis historical overview molecular mechanisms biomarkers |
| title | The landscape of lncRNAs in gastric cancer: from molecular mechanisms to potential clinical applications |
| title_full | The landscape of lncRNAs in gastric cancer: from molecular mechanisms to potential clinical applications |
| title_fullStr | The landscape of lncRNAs in gastric cancer: from molecular mechanisms to potential clinical applications |
| title_full_unstemmed | The landscape of lncRNAs in gastric cancer: from molecular mechanisms to potential clinical applications |
| title_short | The landscape of lncRNAs in gastric cancer: from molecular mechanisms to potential clinical applications |
| title_sort | landscape of lncrnas in gastric cancer from molecular mechanisms to potential clinical applications |
| topic | long non-coding RNAs gastric cancer gastric carcinogenesis historical overview molecular mechanisms biomarkers |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1237723/full |
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